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Mashup Score: 1Testing transgenic T cells against malignant brain tumors - 7 month(s) ago
Scientists from the German Cancer Research Center (DKFZ) and the University Medical Center Mannheim (UMM) have successfully tested a new form of cellular immunotherapy against brain tumors in mice for …
Source: medicalxpress.comCategories: General Medicine News, Latest HeadlinesTweet
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Mashup Score: 0CD25high Effector Regulatory T Cells Hamper Responses to PD-1 Blockade in Triple-Negative Breast Cancer - 7 month(s) ago
An imbalance between effector CD8+ T cells and CD25high effector Tregs marks immunosuppressive microenvironments in αPD-1–resistant TNBC and can be reversed through effector Treg depletion to increase αPD-1 efficacy.
Source: aacrjournals.orgCategories: Hem/Onc News and Journals, Latest HeadlinesTweet-
From the September 15 issue— CD25high Effector Regulatory #TCells Hamper Responses to PD-1 Blockade in Triple-Negative #BreastCancer, by Fattori et al. https://t.co/8IaBgY7LUX @anne_chretien @TumImmuno_CRCM https://t.co/JAGho89RvE
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Mashup Score: 1
The cellular metabolic state alters BTN2A1 and BTN3A levels to convey stress to surveilling Vγ9Vδ2 T cells.
Source: aacrjournals.orgCategories: Hem/Onc News and Journals, Latest HeadlinesTweet-
Read this week's Cancer Discovery #ResearchWatch: AMPK Induces BTN3A and BTN2A1 Surface Levels to Convey Stress to γδ #TCells, summarizing the work of @MuradRMamedov, @MarsonLab et al. https://t.co/WWSg6mhXrU @UCSF @GladstoneInst https://t.co/g3bPzBd8hk
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Mashup Score: 17Neoantigen-specific stem cell memory-like CD4+ T cells mediate CD8+ T cell-dependent immunotherapy of MHC class II-negative solid tumors - 8 month(s) ago
Nature Immunology – In cancer, neoantigen (NeoAg)-specific CD8+ T cells capable of direct tumor recognition have been extensively studied but little is known of the role of NeoAg-specific…
Source: www.nature.comCategories: General Medicine News, Latest HeadlinesTweet-
Scientists harness 'helper' #TCells to treat tumors @ljiresearch @jclinicalinvest @natimmunol https://t.co/MC50a9HxL4 https://t.co/yeLJ9dzJ7h
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Mashup Score: 0Calls for Papers - 8 month(s) ago
Discovery Immunology is a new, Open Access journal covering novel discoveries in cellular and molecular immunology. Browse our calls for papers, and submit
Source: academic.oup.comCategories: General Medicine News, Latest HeadlinesTweet-
Contribute insights from the rapidly-changing field of #Tcells at barrier sites and submit your manuscript for the upcoming Special Collection from @discovimmunol. @britsocimm Find out more here: https://t.co/z90QVOYZKm https://t.co/DLWnDJu7Kw
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Mashup Score: 1HIV-1-induced nuclear invaginations mediated by VAP-A, ORP3, and Rab7 complex explain infection of activated T cells - 8 month(s) ago
Nature Communications – Viruses such as HIV-1 must deliver their content into host T-cell nuclei to replicate. Here, Santos et al. show that endocytosed HIV-1 promotes nuclear envelope invagination…
Source: www.nature.comCategories: Infectious Disease, Latest HeadlinesTweet-
🔬 Dr. Aurelio Lorico's team at @TouroNevada reported that #HIV-1-induced nuclear invaginations mediated by VAP-A, ORP3, and Rab7 complex explain the infection of activated #TCells. Learn more about the mechanism of HIV nuclear entry at @naturecomms! 🔗 https://t.co/VuVAy9Alcu https://t.co/Fj0j1IO3zB
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Mashup Score: 6Gut-licensed β7+ CD4+ T cells contribute to progressive retinal ganglion cell damage in glaucoma - 9 month(s) ago
Gut-licensed β7-expressing CD4+ T cells can infiltrate the retina by inducing MAdCAM-1 expression and contribute to glaucoma pathogenesis.
Source: www.science.orgCategories: Future of Medicine, Latest HeadlinesTweet-
A previously unknown ‘gut-retina’ axis allows gut-homing CD4+ #Tcells to infiltrate the retina and drive progressive eye damage in #glaucoma, show new experiments in mice and patient samples that probe the autoimmune roots of the condition. https://t.co/kZo6NMYtll @ScienceTM https://t.co/68QJKAvMWj
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Mashup Score: 0
Artesunate (ART) is a derivative of artemisinin. Compared with artemisinin, ART has excellent water solubility, high stability and oral bioavailability. In this review, the application of ART in classic autoimmune diseases such as rheumatoid arthritis, systemic lupus erythematosus and ulcerative colitis is summarized. ART exhibited similar or even better efficacy than other highly effective immunosuppressive agents, such as methotrexate and cyclophosphamide. In addition, ART exerts its pharmacological effects mainly by inhibiting the production of inflammatory factors, reactive oxygen species, autoantibodies and the migration of cells to reduce damage to tissues or organs. Moreover, ART widely affected the NF-κB, PI3K/Akt, JAK/STAT and MAPK pathways to exert pharmacological effects.
Source: www.futuremedicine.comCategories: Hem/Onc News and Journals, Latest HeadlinesTweet-
Artesunate exerts its pharmacological effects mainly through #NF-κB, #PI3K/Akt, #JAK/ STAT, #MAPK pathways, and is also widely involved in the regulation of #Tcells, #Bcells, and #macrophages Read our latest review on the role of artesunate online: https://t.co/bItUGxD72S
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Mashup Score: 0Considerations for Choosing T Cell Assays during a Pandemic - 10 month(s) ago
Abstract. The appropriate immunosurveillance tools are foundational for the creation of therapeutics, vaccines, and containment strategies when faced with outbr
Categories: Allergy-Immunology, Latest HeadlinesTweet-
#BriefReview by Jaclyn Law & former #JI_editor @Tania_WattsUofT @UofT discussing “Considerations for choosing #TCellAssays during a #pandemic” #ReadTheJI #immunology #SARSCoV2 #TCells #COVID 👉 https://t.co/oqV6IxfztE https://t.co/Y3MuYer0xo
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Mashup Score: 0Th1 Cells Alter the Inflammatory Signature of IL-6 by Channeling STAT Transcription Factors to Alu-like Retroelements - 10 month(s) ago
Key Points. Th1 cells alter the transcriptional output of IL-6 during acute inflammation.IL-6 and IFN-γ activities combine to steer tissue responses to inflamma
Categories: Allergy-Immunology, Latest HeadlinesTweet-
#JI_TopRead from Simon A. Jones @cardiffuni | Effector #Tcells modify transcription of #IL6 during inflammation through regulatory interplay between #STAT1 & #STAT3 #ReadTheJI #immunology #AuthorChoice #FreetoRead 👉 https://t.co/7kIwz0pe51 https://t.co/J5YibQqWEJ
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Testing transgenic #TCells against malignant #brainTumors @DKFZ https://t.co/gpYrvRLWxd