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Mashup Score: 1
Fibromyalgia (FM) is a chronic condition characterized by generalized musculoskeletal pain associated with other symptoms, especially sleep and mood disorders, fatigue, and cognitive dysfunctions. The etiopathogenesis of FM is not sufficiently known, and regardless of numerous research, the clinical presentation is nonspecific, which makes it difficult to approve a timely diagnosis and, subsequently, an adequate therapeutic approach. Genetic, hormonal, immunological, and environmental factors are cited as potential factors in the development of this condition. Diagnosis is based on a clinical approach and known diagnostic criteria, while additional methods, such as radiographic, magnetic resonance, or laboratory analyses, can be useful to exclude other conditions. The heterogeneity of FM significantly impacts both diagnosis and treatment, as it presents a wide spectrum of symptoms that vary in severity, combinations, and underlying contributing factors. This variability is a challenge
Source: www.mdpi.comCategories: General Medicine News, General HCPsTweet
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Mashup Score: 0
The complexion of phenotypically severe patients first described in the long QT syndrome (LQTS) registry have naturally evolved to a milder phenotype represented in the contemporary literature.1,2 We now recognize that up to 75% of genotype positive LQTS patients may have either concealed disease or a borderline abnormal QTc.3 This variable penetrance and expressivity has been illuminated via inherited arrhythmia clinics, accessible genetic testing and familial screening. Provocation testing, primarily in the form of exercise QTc dynamics, has therefore become an integral part of probabilistic diagnosis and phenotyping.
Source: www.heartrhythmjournal.comCategories: General Medicine News, Cardiology News and JournTweet
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Mashup Score: 0
Preliminary data show that AVA6000 led to robust and clinically meaningful tumor shrinkage in patients with salivary gland cancer.
Source: www.onclive.comCategories: General Medicine News, Oncologists1Tweet
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Mashup Score: 0
BACKGROUND: Metabolic syndrome heightens cardiovascular disease risk primarily through increased arterial stiffness. We previously demonstrated the involvement of YAP (Yes-associated protein) in high-fat/high-sucrose diet (HFHSD)–induced arterial stiffness via modulation of PPM1B (protein phosphatase Mg2+/Mn2+–dependent 1B)-lysine 63(K63) deubiquitination. In this study, we aimed to elucidate the role and mechanisms underlying PPM1B deubiquitination in HFHSD-induced arterial stiffness. METHODS: Enzymes governing PPM1B deubiquitination were identified through small interfering RNA (siRNA) screening and mass spectrometry. Glutathione S-transferase pull-down, coimmunoprecipitation, protein purification, and immunofluorescence were used to explore the mechanism underlying PPM1B deubiquitination. Doppler ultrasound was used to evaluate HFHSD-induced arterial stiffness in mice, and telemetry was used to record pulsatile (systolic and diastolic) blood pressure. RESULTS: Smooth muscle cell–spe
Source: www.ahajournals.orgCategories: General Medicine News, CardiologistsTweet
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Mashup Score: 10We need medical leadership built on trust - 2 hour(s) ago
Recent events have shown how easily trust can be lost, writes Charlotte Summers Trust is central to the practice of medicine, but recent events have shown it to be fragile, even within our professional communities. In 2022, the Ipsos Global Trustworthiness Monitor asked people from 29 countries what attributes were most important when deciding whether to trust an organisation or institution.1 The top three responses were: “If it is reliable/keeps its promises,” “If it is open and transparent about what it does,” and “If it behaves responsibly.” Recent events have shown that our medical community has lessons to learn. The announcement by the UK Foundation Programme Office (UK FPO) that the appointment process for the Specialised Foundation Programme will change in 2025 to preference-informed allocation, a …
Source: www.bmj.comCategories: General Medicine News, CardiologistsTweet
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Mashup Score: 0Tariffs on medical devices will raise costs. Here's what to know - 2 hour(s) ago
The tariffs will boost medical device prices, but hospitals may be temporarily shielded by their contracts.
Source: www.modernhealthcare.comCategories: General Medicine News, General HCPsTweet
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Mashup Score: 0Health Care Delivery and Financial Considerations in Amyotrophic Lateral Sclerosis Clinics | Neurology - 2 hour(s) ago
Background and ObjectivesClinical care for people living with amyotrophic lateral sclerosis (PLWALS) is directed at slowing disease progression and symptom management. The American Academy of Neurology recommends a multidisciplinary approach to providing …
Source: www.neurology.orgCategories: General Medicine News, NeurologyTweet
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Mashup Score: 2
Two more people in metro Atlanta have been diagnosed with measles, the Georgia Department of Public Health confirmed on Friday.
Source: www.atlantanewsfirst.comCategories: General Medicine News, Infectious DiseaseTweet
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Mashup Score: 4
Xenotransplantation offers a potential solution to the organ shortage crisis. A 62-year-old hemodialysis-dependent man with long-standing diabetes, advanced vasculopathy, and marked dialysis-access…
Source: www.nejm.orgCategories: General Medicine News, General HCPsTweet
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Mashup Score: 29
Since my Internet Archive indexes of both CDC.gov and FDA.gov seem to have gotten a lot of positive responses, I’m following up by tackling a much larger federal healthcare department website: The
Source: acasignups.netCategories: General Medicine News, Infectious DiseaseTweet
Full read review and overview of Fibromyalgia - manifestations, pathophysiology, treatments and guidelines. Multidisciplinary, patient-centered treatment should includes a combination of pharmacological and nonpharmacological options. https://t.co/x4OVeQ5RJz https://t.co/i1fD6XQbnx