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Mashup Score: 14Matrix mechano-sensing at the invasive front induces a cytoskeletal and transcriptional memory supporting metastasis - 22 hour(s) ago
Nature Communications – Interactions with the extracellular matrix (ECM) control tumor proliferation, invasion and metastasis. Here, authors provide spatial information on ECM organization and how…
Source: www.nature.comCategories: General Medicine News, General HCPsTweet
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Mashup Score: 18Functional analysis of cancer-associated germline risk variants - 23 hour(s) ago
Nature Genetics – Analysis of 4,041 single-nucleotide variants (SNVs) linked to 13 cancers performed in primary human cell types identifies 380 potentially regulatory SNVs and their putative target…
Source: www.nature.comCategories: General Medicine News, General HCPsTweet-
A comprehensive genomic screen has identified 380 single nucleotide variants crucial for #Cancer development. These findings could enhance genetic screening and inform new therapeutic targets. @sumedicine @NatureGenet https://t.co/sIJBRinMMf https://t.co/DsiZEqOBRJ
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Mashup Score: 11Information‐Distilled Generative Label‐Free Morphological Profiling Encodes Cellular Heterogeneity - 24 hour(s) ago
CytoMAD is a self-supervised, multitask, generative deep learning model that extracts biologically significant cell morphology for integrated cytometric analysis while minimizing technical variabilit…
Source: advanced.onlinelibrary.wiley.comCategories: General Medicine News, General HCPsTweet-
#AI tool CytoMAD enhances cancer diagnosis with rapid, label-free cell imaging, improving treatment precision. This generative AI model offers unbiased analysis, revolutionizing cell imaging and drug discovery. @hkuniversity @advscinews https://t.co/EFbRFW8ZUU… https://t.co/xuyu4GNbBQ
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Mashup Score: 4
Pelvic organ prolapse (POP) is a significant health challenge for women, especially with the lack of optimal surgical options post-withdrawal of synthetic transvaginal meshes. The study pioneers degr…
Source: advanced.onlinelibrary.wiley.comCategories: General Medicine News, General HCPsTweet-
#Innovative degradable 3D meshes, utilizing FDA-approved polymers, offer promising advancements in pelvic organ prolapse repair by enhancing tissue integration and reducing foreign body response. @Hudson_Research @advscinews https://t.co/H0w61k1nc5 https://t.co/oU0SouVq3L
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Mashup Score: 1Mental and Somatic Conditions in Children With the Broad Avoidant Restrictive Food Intake Disorder Phenotype - 1 day(s) ago
This cohort study among Swedish children with and without avoidant restrictive food intake disorder (ARFID) examines coexisting mental and somatic conditions among children with ARFID and characterizes their health care needs.
Source: jamanetwork.comCategories: General Medicine News, General HCPsTweet-
#Children with avoidant restrictive food intake disorder (ARFID) face heightened risks of psychiatric and physical conditions, including autism and epilepsy, underscoring the need for early detection and comprehensive care. @JAMAPeds @AAPJournals https://t.co/SrqFabPXns… https://t.co/V05w28NFEH
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Mashup Score: 18
Nature Mental Health – In this study, the authors report that maternal plasma biomarkers of acetaminophen exposure during pregnancy were associated with an increased risk of a diagnosis of child…
Source: www.nature.comCategories: General Medicine News, General HCPsTweet-
Prenatal acetaminophen exposure is linked to altered placental gene expression and increased #Adhd risk in children, with stronger effects observed in females. Objective biomarker data supports these findings. @NatMentHealth https://t.co/azh93eb7ya https://t.co/Sx4wNCRecr
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Mashup Score: 9Artificial Intelligence–Enabled Wearable Devices and Nocturnal Scratching in Mild Atopic Dermatitis - 5 day(s) ago
This cohort study evaluates the accuracy and efficacy of an artificial intelligence–enabled wearable sensor with closed-loop haptic feedback to decrease nocturnal scratch in patients with mild atopic dermatitis who report a moderate to severe degree of scratching.
Source: jamanetwork.comCategories: General Medicine News, General HCPsTweet-
AI-driven #WearableSensor with vibratory feedback reduces nocturnal scratching by 28% in adults with mild #AtopicDermatitis, without affecting sleep. Future studies needed for broader validation. @JAMADerm https://t.co/9vmXwEg8qi https://t.co/uXogBrRKwd
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Mashup Score: 11
Nature Aging – The authors describe how aging rewires the cellular composition of mouse mammary tissues and impacts the transcriptomic and epigenomic programs of mammary epithelial, fibroblast and…
Source: www.nature.comCategories: General Medicine News, General HCPsTweet-
Aging #BreastTissue undergoes cellular and molecular changes that may increase ##CancerRisk. A new atlas maps these shifts, offering insights into early detection and prevention strategies. @NatureAging https://t.co/uma0dPFGI5 https://t.co/P50yHtJiHi
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Mashup Score: 20
Nature Microbiology – In a randomized controlled trial, the effect of sulforaphane (provided as a broccoli sprout extract) on fasting blood glucose in individuals with prediabetes was tested, in…
Source: www.nature.comCategories: General Medicine News, General HCPsTweet-
#Sulforaphane, a compound in #BroccoliSprouts, shows potential in reducing fasting #BloodSugarLevels in prediabetes. This finding suggests a new avenue for precision treatment in managing prediabetes. @NatureMicrobiol https://t.co/wWuKF9S3GT https://t.co/uvzKuXUDwW
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Mashup Score: 21
High sugar–containing foods are readily consumed, even after meals and beyond fullness sensation (e.g., as desserts). Although reward-driven processing of palatable foods can promote overeating, the neurobiological mechanisms that underlie the selective …
Source: www.science.orgCategories: General Medicine News, General HCPsTweet-
#The brain's opiate pathway triggers sweet cravings even when full, driven by POMC neurons and ß-endorphin release. This insight may inform obesity treatments by targeting #OpiateReceptors. @sciencemagazine https://t.co/iZ5xKpYOJq https://t.co/Rmi9kSQ7IB
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Researchers have mapped how ##CancerCells exploit the #ExtracellularMatrix to spread. This insight could lead to treatments that prevent metastasis by targeting the matrix and related genes. @kingscollegelon @NatureComms https://t.co/u93PHpQsWQ https://t.co/Jv6dvNx66W