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Mashup Score: 35Imaging of tumor-associated macrophage dynamics during immunotherapy using a CD163-specific nanobody-based immunotracer | PNAS - 6 day(s) ago
Immunotherapies have emerged as an effective treatment option for immune-related diseases, such as cancer and inflammatory diseases. However, varia…
Source: www.pnas.orgCategories: General Medicine News, General HCPsTweet
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Mashup Score: 12Evolving the lock to fit the key to create a family of G protein-coupled receptors potently activated by an inert ligand | PNAS - 8 day(s) ago
We evolved muscarinic receptors in yeast to generate a family of G protein-coupled receptors (GPCRs) that are activated solely by a pharmacological…
Source: www.pnas.orgCategories: General Medicine News, General HCPsTweet-
A novel gene therapy approach shows potential in reducing chronic #Pain by targeting peripheral neurons. This chemogenetic tool could offer a new pathway for pain management in the future. @PNASNews @CellCellPress https://t.co/kjwRokDL0X https://t.co/wZyXgrpbVc
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Mashup Score: 23Estimating the lives that could be saved by expanded access to weight-loss drugs | PNAS - 14 day(s) ago
Obesity is a major public health crisis in the United States (US) affecting 42% of the population, exacerbating a spectrum of other diseases and co…
Source: www.pnas.orgCategories: General Medicine News, Expert PicksTweet-
For once, @elonmusk and I agree! ~75% of the U.S. is overweight/obese. If we helped even those with BMI>35, we would save lives & reduce medical expenditures If we applied these meds like the trials, we would shift the BMI curves of the population đ https://t.co/po0MehkcP5 https://t.co/botzwLGAAb https://t.co/rYyTK6A6HF
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Mashup Score: 7Sculpting new visual categories into the human brain | PNAS - 16 day(s) ago
Learning requires changing the brain. This typically occurs through experience, study, or instruction. We report an alternate route for humans to a…
Source: www.pnas.orgCategories: General Medicine News, NeurologyTweet-
âSculpting new visual categories into the human brainâ by Coraline Iordan et al. PNAS https://t.co/pLvMdEE14V
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Mashup Score: 5Neural responses to social rejection reflect dissociable learning about relational value and reward | PNAS - 19 day(s) ago
Social rejection hurts, but it can also be informative: Through experiences of acceptance and rejection, people identify partners interested in con…
Source: www.pnas.orgCategories: General Medicine News, NeurologyTweet-
âNeural responses to social rejection reflect dissociable learning about relational value and rewardâ by Leor Hackel et al. PNAS https://t.co/dOZhISQhaV
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Mashup Score: 4
The fact that rapid brain size increase was clearly a key aspect of human evolution has prompted many studies focusing on this phenomenon, and many…
Source: www.pnas.orgCategories: General Medicine News, NeurologyTweet-
âHominin brain size increase has emerged from within-species encephalizationâ by Chris Venditti et al. PNAS https://t.co/zQJw66uAxm
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Mashup Score: 8Multi-Component, Time-Course screening to develop combination cancer therapies based on synergistic toxicity | PNAS - 1 month(s) ago
Clinical trials in cancer are ideally built on a foundation of sound mechanistic rationale and well-validated drug activity in relevant disease mod…
Source: www.pnas.orgCategories: General Medicine News, Hem/OncsTweet-
Multi-Component, Time-Course screening to develop combination cancer therapies based on synergistic toxicity | PNAS https://t.co/Q9N9Ccd0lz Read the background story of how the VIPOR drugs were discovered to have synergy in LBCL.
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Mashup Score: 2Postmarital residence rules and transmission pathways in cultural hitchhiking | PNAS - 1 month(s) ago
Cultural evolutionary processes can often lead to a statistical association between neutral and adaptive traits during episodes of population dispe…
Source: www.pnas.orgCategories: General Medicine News, NeurologyTweet-
âSocial tolerance and success-biased social learning underlies the cultural transmission of an induced extractive foraging tradition in a wild tool-using primateâ by Rachel Kendal et al. PNAS https://t.co/at3kPCM2Pk
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Mashup Score: 23Alveolar macrophage function is impaired following inhalation of berry e-cigarette vapor | PNAS - 2 month(s) ago
In the lower respiratory tract, the alveolar spaces are divided from the bloodstream and the external environment by only a few microns of intersti…
Source: www.pnas.orgCategories: General Medicine News, General HCPsTweet-
Berry-flavored #vapes impair lung đ« immune response.  New study reports alterations in alveolar macrophages function following exposure to berry-flavored #ecigarettes, which lead to poor #immune responses to pathogens and reduced host survival.  https://t.co/TQHS9WkI8A https://t.co/WwqG0UaK4Y
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Mashup Score: 5Brighter nights and darker days predict higher mortality risk: A prospective analysis of personal light exposure in >88,000 individuals | PNAS - 2 month(s) ago
Light enhances or disrupts circadian rhythms, depending on the timing of exposure. Circadian disruption contributes to poor health outcomes that in…
Source: www.pnas.orgCategories: General Medicine News, General HCPsTweet-
Brighter nights and darker days predict higher mortality risk: A prospective analysis of personal light exposure in >88,000 individuals In @PNASNews https://t.co/B4KGoiXI7o #longevity #healthspan https://t.co/zj3cLPigPg
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New technology identifies patients likely to benefit from cancer immunotherapy by targeting CD163+ macrophages with nanobody tracers. This advancement aids in personalizing #Treatment strategies. @vubrussel @PNASNews https://t.co/IvyIVlvN9y https://t.co/eyv8nGpxz6