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Mashup Score: 1Understanding Academic Medical Centers: Simone’s Maxims - 5 hour(s) ago
Academic medical centers today represent a unique fusion of traditional academia, hospital functions, several levels of education, and, above all, patients. They are complex organizations trying to discharge an often conflicting melange of responsibilities. This complexity has grown in recent years with the increasingly rapid rate of change (1), stressing both faculty and leadership (2, 3). Lamenting the toll of change is not new (4). However, the qualitative difference in recent change is underscored by the shift in focus of two articles, 15 years apart, on academic governance by Petersdorf (5, 6), especially as they have affected deans and their dramatically shrinking tenures. Economic turmoil and its consequences are blamed most often for the angst in academic medical centers (7). And yet, some blame the faculty and leadership for not changing fast enough (8) or for choosing doomed strategic pathways in response to those pressures (9). In fact, a Forum on the Future of Academic Medi
Source: aacrjournals.orgCategories: General Medicine News, General HCPsTweet
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Mashup Score: 4Sequencing of anti-CD19 therapies in the management of diffuse large B-cell lymphoma - 16 hour(s) ago
Abstract. Several second- and third-line immunotherapeutic options for patients with relapsed or refractory diffuse large B-cell lymphoma (DLBCL) ineligible for autologous stem cell transplant are directed against the B-cell antigen CD19. The anti-CD19 monoclonal antibody tafasitamab, paired with the immunomodulator lenalidomide, mediates antibody-dependent cellular toxicity and cellular phagocytosis; the antibody–drug conjugate loncastuximab tesirine delivers the DNA-cross-linking agent tesirine via CD19 binding and internalization; and CD19-directed chimeric antigen receptor T-cell therapy (CAR-T) products are engineered from autologous T cells. While CD19 expression is assessed at diagnosis, clinically relevant thresholds of CD19 expression—which may not be detectable with current routine methodologies—have not been defined and may vary between CD19-directed treatment modalities. Determining optimal treatment sequencing strategies with CD19-directed therapy has been hampered by the
Source: aacrjournals.orgCategories: General Medicine News, Onc News and JournalsTweet
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Mashup Score: 0Unveiling an Association between Waterpipe Smoking and Bladder Cancer Risk: A Multicenter Case–Control Study in Iran - 19 hour(s) ago
AbstractBackground:. Limited data exist for the association between bladder cancers and waterpipe smoking, an emerging global public health concern.Methods:. We used the IROPICAN database in Iran and used multivariable logistic regression, adjusting for cigarette smoking, opium use, and other confounding factors. In addition, we studied the association between exclusive waterpipe smoking and bladder cancer.Results:. We analyzed 717 cases and 3,477 controls and a subset of 215 patients and 2,145 controls who did not use opium or cigarettes. Although the OR adjusted for opium, cigarettes, and other tobacco products was 0.92 [95% confidence interval (CI), 0.69–1.20], we observed a statistically significant elevated risk in exclusive waterpipe smokers (OR = 1.78; 95% CI, 1.16–2.72) compared with non-users of opium or any tobacco. Associations were strongest for smoking more than two heads/day (OR = 2.25; 95% CI, 1.21–4.18) and for initiating waterpipe smoking at an age less than 20 (OR = 2
Source: aacrjournals.orgCategories: General Medicine News, Onc News and JournalsTweet
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Mashup Score: 36Germline Testing identifies Pathogenic/Likely Pathogenic Variants in Patients with Pancreatic Neuroendocrine Tumors - 2 day(s) ago
Abstract. 10% of pancreatic neuroendocrine tumors (pNETs) are related to inherited syndromes (MEN1, MEN4, VHL, NF1, TSC). Growing evidence suggests that clinically sporadic pNETs can also harbor germline pathogenic variants. In this study, we report the prevalence of pathological/likely pathological germline variants (P/LP) in a high-risk cohort and an unselected cohort. We collected clinical data of patients with pNETs seen at MD Anderson Cancer Center (MDACC) and Johns Hopkins Hospital (JHH). High-risk cohort included (n=132) patients seen at MDACC who underwent germline testing for high-risk criteria (early onset, personal or family history of cancer and syndromic features) between 2013-2019. Unselected cohort (n=106) patients seen at JHH who underwent germline testing following their diagnosis of pNETs between 2020 to 2022. In the high-risk cohort (n=132), 33% (n=44) had P/LP variants. The majority of the patients had P/LP variants in MEN1 56% (n=25), followed by DNA repair pathway
Source: aacrjournals.orgCategories: General Medicine News, Hem/OncsTweet-
In @CAPR_AACR from @hopkinskimmel & @MDAndersonNews #PancreaticCancer teams: Germline Testing identifies Pathogenic/Likely Pathogenic Variants in Patients with Pancreatic Neuroendocrine Tumors https://t.co/PPLsGC8wT4 In an unselected population, 1 in 5 harbor germline alterations… https://t.co/nb8IGxwIbU
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Mashup Score: 0
Convergence Science | Cancer Research | American Association for Cancer Research .aacrcontent { display: flex; flex-direction: row; justify-content: space-between; align-items: stretch; } .intro { margin-top: 26px; font-size: 1.2em; } /* ****************** LEFT SIDE ****************** */ .left-side{ color: #000000; background-color: #fff; max-width: 710px; margin-right: 26px; } .left-side h3{ margin-bottom: 26px; } .node { line-height: 1.2em; margin-left: 12px; } .node2 {line-height: 1.0em; }…
Source: aacrjournals.orgCategories: General Medicine News, Onc News and JournalsTweet
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Mashup Score: 0
Targeted degradation of EP300 with a novel PROTAC agent in neuroblastoma cells was found to cause widespread loss of gene expression and cell death in vitro and in vivo.
Source: aacrjournals.orgCategories: General Medicine News, Oncologists1Tweet
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Mashup Score: 1Reviewer Training Program | Cancer Epidemiology, Biomarkers & Prevention | American Association for Cancer Research - 2 day(s) ago
Reviewer Training Program | Cancer Epidemiology, Biomarkers & Prevention | American Association for Cancer Research .aacrcontent h2{ margin-top: 34px; margin-bottom: 16px; } .aacrcontent ul {list-style-image: url(‘/ImageLibrary/cebp/icons/cebp_bullet-9px.png’);} .aacrcontent ul li{margin-bottom: 12px;} .aacrcontent .mainbox{ display: flex; flex-direction: row; justify-content: space-around; align-items: stretch; align-content: flex-start; } .mainbox .box1{ width: 45%; margin: auto; padding:0; vertical-align: middle; } .mainbox .box1 ul { list-style-image: url(‘/ImageLibrary/cebp/icons/cebp-checkmark.png’); text-align: left; } .mainbox .box1 ul…
Source: aacrjournals.orgCategories: General Medicine News, Onc News and JournalsTweet
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Mashup Score: 21
Summary. Precision drug development is focusing on targeting tumor cell surface proteins for therapeutic delivery, maximizing biomarker identified on-target damage to the tumor while minimizing toxicity. A recent article demonstrated high expression of B7-H4 antigen on resistant ovarian cancer cells and described preclinical activity of B7-H4–directed antibody–drug conjugate.See related article by Gitto et al., p. 1567
Source: aacrjournals.orgCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 10Targeting Senescence for Next-Generation Cancer Treatments - 3 day(s) ago
Summary:. Cellular senescence has paradoxical effects on cancer emergence, progression, and therapeutic response. We herein identify four lessons that emerged from studying senescence interaction with cancer and emphasize four bottlenecks in the therapeutic manipulation of cellular senescence to prevent or cure cancer.
Source: aacrjournals.orgCategories: General Medicine News, Onc News and JournalsTweet
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Mashup Score: 11
Summary:. Beyond lipid membrane compartments, cells including cancer cells utilize various membraneless compartments, often termed biomolecular condensates, to regulate or organize key cellular processes underlying physiologic or pathologic phenotypes. In this commentary, the emergence of biomolecular condensation in cancer biology is highlighted, with a focus on key unanswered questions and with implications for improving the understanding of cancer pathogenesis and developing innovative cancer management strategies.
Source: aacrjournals.orgCategories: General Medicine News, Onc News and JournalsTweet
RT @AlexisDNeoMD: @TPP_MD Words to live by: https://t.co/BkbzejAc0L