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Mashup Score: 3High-purity CTC RNA sequencing identifies prostate cancer lineage phenotypes prognostic for clinical outcomes - 4 hour(s) ago
Abstract. The development of treatment resistance remains universal for patients with metastatic prostate cancer, driven by AR alterations and lineage state transitions. Identifying the evolution of lineage transitions in treatment resistance has been limited by the challenges of collecting serial tissue biopsies on treatment, which can be overcome using blood-based liquid biopsies. Utilizing a novel circulating tumor cell (CTC) isolation approach, we collected 273 CTC samples from 117 patients with metastatic prostate cancer for RNA sequencing. 146 samples from 70 patients had tumor purity comparable to tissue biopsies. We identified four CTC transcriptional phenotypes, mirroring lineage states identified in tissue. Patients with a luminal-B-like CTC phenotype defined by persistent AR signaling and high proliferation, as well as those with a neuroendocrine CTC phenotype, had significantly shorter survival than patients with luminal-A-like and low proliferation phenotypes. In a prospec
Source: aacrjournals.orgCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 12Stem-like memory and precursors of exhausted T cells share a common progenitor defined by ID3 expression - 5 day(s) ago
ID3 defines stem-like T cells with high developmental potential that sustain T cell responses to chronic infection and cancer.
Source: www.science.orgCategories: General Medicine News, Hem/OncsTweet-
RT @JohnstoneRicky: https://t.co/v3TqmbFwQa First paper from the @JohnstoneLab for the year and a brilliant collaboration with @TheDohertyI…
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Mashup Score: 4AtlasXomics Inc. on LinkedIn: #epigenetics #genomics - 9 day(s) ago
Cheers to a year of breakthroughs at Atlasxomics—and an even more innovative 2025 ahead! Together, let’s push the boundaries of discovery. #epigenetics…
Source: www.linkedin.comCategories: General Medicine News, Hem/OncsTweet-
Fantastic work from a great team @AtlasXomics - allowing @CPDR_Labs @EllisLab_ to look at #prostatecancer through a different lens #prostatecancerdisparity https://t.co/aBXcQT1QwF
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Mashup Score: 0Drug-Induced Epigenomic Plasticity Reprograms Circadian Rhythm Regulation to Drive Prostate Cancer toward Androgen Independence - PubMed - 18 day(s) ago
Understanding how prostate cancers adapt to AR-targeted interventions is critical for identifying novel drug targets to improve the clinical management of treatment-resistant disease. Our study revealed an enzalutamide-induced epigenomic plasticity toward prosurvival signaling and uncovered the circ …
Source: pubmed.ncbi.nlm.nih.govCategories: General Medicine News, Hem/OncsTweet-
Gene expression data enrichment of genesets involved in inflammation (including NFkB) mitotic checkpoints. These data were also enriched in DARANA patient samples @zwartlab involving neoadj AR inhibition. https://t.co/N8XRdrtPa6 https://t.co/mRLZ3u6cWM
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Mashup Score: 3
Toni Choueiri: Honored by the King Hussein Cancer Foundation / cancer, Dana-Farber Cancer Institute, DFCI, HRH Princess Ghida Talal, King Hussein Cancer
Source: oncodaily.comCategories: General Medicine News, Hem/OncsTweet-
RT @oncodaily: Honored by the King Hussein Cancer Foundation - @DrChoueiri (@DanaFarber/@HarvardMed) https://t.co/s4FNNEIAaX #Health #Med…
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Mashup Score: 3
Toni Choueiri: Honored by the King Hussein Cancer Foundation / cancer, Dana-Farber Cancer Institute, DFCI, HRH Princess Ghida Talal, King Hussein Cancer
Source: oncodaily.comCategories: General Medicine News, Hem/OncsTweet-
RT @oncodaily: Honored by the King Hussein Cancer Foundation - @DrChoueiri (@DanaFarber/@HarvardMed) https://t.co/s4FNNEIAaX #Health #Med…
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Mashup Score: 5The official website of the Nobel Prize - NobelPrize.org - 4 month(s) ago
“When I meet patients who tell me: ‘You saved my life,’ it is an unforgettable moment.” Read about laureates James P. Allison and Tasuku Honjo and their discovery of a new cancer therapy. The first woman to be awarded a Nobel Prize, the first individual to be awarded two Nobel Prizes and still today the only individual with two Nobel Prizes in two different scientific categories is Marie Skłodowska Curie. She developed the term radioactivity, discovered the chemical elements polonium and radium and
Source: www.nobelprize.orgCategories: General Medicine News, Hem/OncsTweet-
Charles B. Huggins – Biographical - https://t.co/9WhuksFyg7 https://t.co/40KtVJC72N
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Mashup Score: 1The official website of the Nobel Prize - NobelPrize.org - 4 month(s) ago
“When I meet patients who tell me: ‘You saved my life,’ it is an unforgettable moment.” Read about laureates James P. Allison and Tasuku Honjo and their discovery of a new cancer therapy. The first woman to be awarded a Nobel Prize, the first individual to be awarded two Nobel Prizes and still today the only individual with two Nobel Prizes in two different scientific categories is Marie Skłodowska Curie. She developed the term radioactivity, discovered the chemical elements polonium and radium and
Source: www.nobelprize.orgCategories: General Medicine News, Hem/OncsTweet-
Charles B. Huggins – Biographical - https://t.co/9WhuksFyg7 https://t.co/40KtVJC72N
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Mashup Score: 3The official website of the Nobel Prize - NobelPrize.org - 4 month(s) ago
“When I meet patients who tell me: ‘You saved my life,’ it is an unforgettable moment.” Read about laureates James P. Allison and Tasuku Honjo and their discovery of a new cancer therapy. The first woman to be awarded a Nobel Prize, the first individual to be awarded two Nobel Prizes and still today the only individual with two Nobel Prizes in two different scientific categories is Marie Skłodowska Curie. She developed the term radioactivity, discovered the chemical elements polonium and radium and
Source: www.nobelprize.orgCategories: General Medicine News, Hem/OncsTweet-
Charles B. Huggins – Biographical - https://t.co/9WhuksFyg7 https://t.co/40KtVJC72N
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Mashup Score: 864 | Robert Weinberg and the perils of being a Fachidiot - 4 month(s) ago
MIT’s Bob Weinberg is perhaps the world’s most prominent cancer researcher. In this episode, Bob emphasizes that true innovation often comes from blending ideas
Source: podcasts.apple.comCategories: General Medicine News, Hem/OncsTweet-
An interesting podcast from Robert Weinberg. Also available on Spotify https://t.co/yVnjMptoms
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Congrats @JoshLangMD et al. High-purity CTC RNA sequencing identifies prostate cancer lineage phenotypes prognostic for clinical outcomes | Cancer Discovery | American Association for Cancer Research https://t.co/pRlF6uYxsx