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Mashup Score: 0
Convergence Science | Cancer Research | American Association for Cancer Research .aacrcontent { display: flex; flex-direction: row; justify-content: space-between; align-items: stretch; } .intro { margin-top: 26px; font-size: 1.2em; } /* ****************** LEFT SIDE ****************** */ .left-side{ color: #000000; background-color: #fff; max-width: 710px; margin-right: 26px; } .left-side h3{ margin-bottom: 26px; } .node { line-height: 1.2em; margin-left: 12px; } .node2 {line-height: 1.0em; }…
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Mashup Score: 30
Abstract. Pancreatic cancer prevalence increases with age, and disease prognosis is poorer in older individuals. The increased prevalence is driven, undoubtedly, by the multistep accumulation of oncogenic mutations in cancer cells with age. However, fibroblasts are major constituents and key players in pancreatic cancer, and they too undergo age-related changes that may contribute to disease severity. In this issue of Cancer Research, Zabransky and colleagues set out to dissect the effect of age-related changes in pancreatic fibroblasts on pancreatic ductal adenocarcinoma growth and metastasis. They discovered that aged fibroblasts secrete GDF-15, which in turn activates AKT signaling and accelerates tumor progression. These findings provide a mechanistic role for aged fibroblasts in pancreatic cancer, underpinning the importance of normal physiologic processes in tumor progression.See related article by Zabransky et al., p. 1221
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Mashup Score: 47
Aged pancreatic fibroblasts secrete GDF-15 and activate AKT signaling to promote pancreatic cancer growth, highlighting the critical role of aging-mediated changes in the pancreatic cancer microenvironment in driving tumor progression.
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Mashup Score: 20Exploiting Tertiary Lymphoid Structures to Stimulate Antitumor Immunity and Improve Immunotherapy Efficacy - 6 day(s) ago
Abstract. Tumor-associated tertiary lymphoid structures (TLS) have been associated with favorable clinical outcomes and response to immune checkpoint inhibitors in many cancer types, including non–small cell lung cancer. Although the detailed cellular and molecular mechanisms underlying these clinical associations have not been fully elucidated, growing preclinical and clinical studies are helping to elucidate the mechanisms at the basis of TLS formation, composition, and regulation of immune responses. However, a major challenge remains how to exploit TLS to enhance naïve and treatment-mediated antitumor immune responses. Here, we discuss the current understanding of tumor-associated TLS, preclinical models that can be used to study them, and potential therapeutic interventions to boost TLS formation, with a particular focus on lung cancer research.
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Mashup Score: 4
Abstract. The intersection of precision medicine and artificial intelligence (AI) holds profound implications for cancer treatment, with the potential to significantly advance our understanding of drug responses based on the intricate architecture of tumor cells. A recent study by Park and colleagues titled
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Mashup Score: 6
Abstract. Metastasis arises from cancer-cell intrinsic adaptations and permissive tumor microenvironments (TME) that are distinct across different organs. Deciphering the mechanisms underpinning organotropism could provide novel preventive and therapeutic strategies for cancer patients. Rogava and colleagues identified Pip4kc as a driver of liver metastasis, acting by sensitizing cancer cells to insulin-dependent PI3K/AKT signaling, which could be reversed by dual pharmacological inhibition of PI3K and SGLT2 or a ketogenic diet. The study highlights the importance of tumor: microenvironment communication in the context of systemic physiology and points towards potential combination therapies.
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Mashup Score: 0
2023 Covers | Cancer Research | American Association for Cancer Research #aacr_embed_signup .aacr-field-group.input-group ul{list-style: none;} #aacr_embed_signup .aacr-field-group.input-group ul li{display: inline-block; width: fit-content; padding: 20px;} .inputsection input{padding:200px;} .inputsection input[type=radio] + img {cursor: pointer; max-width: 151px;} .inputsection input[type=radio]:checked + img {outline: 4px solid #489dc6; box-shadow: 5px 10px 18px #489dc6, -5px -10px 18px #489dc6;} #aacr_embed_signup .aacr-field-group.input-group ul li input[type=radio]{position: absolute; opacity: 0; width: 0;…
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Mashup Score: 0Volume 84 Issue 8_Supplement | Cancer Research | American Association for Cancer Research - 12 day(s) ago
Cancer Research | 84 | 8_Supplement | April 2024
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Mashup Score: 3Supporting Convergence Science - 12 day(s) ago
Scientific publishing is a cornerstone of disseminating knowledge. One caveat of scientific publishing is that at any one time it is biased toward certain topics relative to others, a reflection of the dynamic nature of scientific discovery over time and the emergence of new technologies. As a result, some areas of cancer biology remain understudied and poorly understood. This reality is compounded by additional factors at play. For example, the ability to bridge gaps in knowledge may prove difficult if investigators from disparate fields are unaware of each other’s work; such investigators may be located in entirely different institutions, if not countries. Alternatively, some areas of cancer research have remained understudied because there is a need for technologies or datasets that have yet to be created. Collectively, these “missed” opportunities within scientific publishing that are centered within the realm of convergence science represent an opportunity for Cancer Research.To s
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Mashup Score: 4
Cancer Research | 84 | 8 | April 2024
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Cancer Research aims to distinguish itself as the home of convergence science with content that will stimulate discussion and support the next series of discoveries within the field. Read some of the top articles in this section: https://t.co/uo7mhRYuoQ https://t.co/kTyfV9VxjH