-
Mashup Score: 0
CRISPR–Cas9 gene editing in T cells can lead to partial or complete loss of the targeted chromosome.
Source: aacrjournals.orgCategories: Hem/Onc News and Journals, Latest HeadlinesTweet
-
Mashup Score: 1MyD88 signaling by neurons induces chemokines that recruit protective leukocytes to the virus-infected CNS - 7 month(s) ago
During viral CNS infection, MyD88 signaling in infected neurons orchestrates recruitment of protective peripheral immune cells.
Source: www.science.orgCategories: Allergy-Immunology, Latest HeadlinesTweet
-
Mashup Score: 1Testing transgenic T cells against malignant brain tumors - 8 month(s) ago
Scientists from the German Cancer Research Center (DKFZ) and the University Medical Center Mannheim (UMM) have successfully tested a new form of cellular immunotherapy against brain tumors in mice for …
Source: medicalxpress.comCategories: General Medicine News, Latest HeadlinesTweet
-
Mashup Score: 0CD25high Effector Regulatory T Cells Hamper Responses to PD-1 Blockade in Triple-Negative Breast Cancer - 8 month(s) ago
An imbalance between effector CD8+ T cells and CD25high effector Tregs marks immunosuppressive microenvironments in αPD-1–resistant TNBC and can be reversed through effector Treg depletion to increase αPD-1 efficacy.
Source: aacrjournals.orgCategories: Hem/Onc News and Journals, Latest HeadlinesTweet
-
Mashup Score: 1
The cellular metabolic state alters BTN2A1 and BTN3A levels to convey stress to surveilling Vγ9Vδ2 T cells.
Source: aacrjournals.orgCategories: Hem/Onc News and Journals, Latest HeadlinesTweet
-
Mashup Score: 17Neoantigen-specific stem cell memory-like CD4+ T cells mediate CD8+ T cell-dependent immunotherapy of MHC class II-negative solid tumors - 8 month(s) ago
Nature Immunology – In cancer, neoantigen (NeoAg)-specific CD8+ T cells capable of direct tumor recognition have been extensively studied but little is known of the role of NeoAg-specific…
Source: www.nature.comCategories: General Medicine News, Latest HeadlinesTweet
-
Mashup Score: 0Calls for Papers - 9 month(s) ago
Discovery Immunology is a new, Open Access journal covering novel discoveries in cellular and molecular immunology. Browse our calls for papers, and submit
Source: academic.oup.comCategories: General Medicine News, Latest HeadlinesTweet
-
Mashup Score: 1HIV-1-induced nuclear invaginations mediated by VAP-A, ORP3, and Rab7 complex explain infection of activated T cells - 9 month(s) ago
Nature Communications – Viruses such as HIV-1 must deliver their content into host T-cell nuclei to replicate. Here, Santos et al. show that endocytosed HIV-1 promotes nuclear envelope invagination…
Source: www.nature.comCategories: Infectious Disease, Latest HeadlinesTweet
-
Mashup Score: 6Gut-licensed β7+ CD4+ T cells contribute to progressive retinal ganglion cell damage in glaucoma - 9 month(s) ago
Gut-licensed β7-expressing CD4+ T cells can infiltrate the retina by inducing MAdCAM-1 expression and contribute to glaucoma pathogenesis.
Source: www.science.orgCategories: Future of Medicine, Latest HeadlinesTweet
-
Mashup Score: 0
Artesunate (ART) is a derivative of artemisinin. Compared with artemisinin, ART has excellent water solubility, high stability and oral bioavailability. In this review, the application of ART in classic autoimmune diseases such as rheumatoid arthritis, systemic lupus erythematosus and ulcerative colitis is summarized. ART exhibited similar or even better efficacy than other highly effective immunosuppressive agents, such as methotrexate and cyclophosphamide. In addition, ART exerts its pharmacological effects mainly by inhibiting the production of inflammatory factors, reactive oxygen species, autoantibodies and the migration of cells to reduce damage to tissues or organs. Moreover, ART widely affected the NF-κB, PI3K/Akt, JAK/STAT and MAPK pathways to exert pharmacological effects.
Source: www.futuremedicine.comCategories: Hem/Onc News and Journals, Latest HeadlinesTweet
Read this week's Cancer Discovery #ResearchWatch: CRISPR–Cas9 Gene Editing in #TCells Induces Site-Specific Chromosome Loss, summarizing the work of @connortsuchida, @BrandesNadav, Raymund Bueno, @yimmieg, @doudna_lab. https://t.co/LZMQiBrkQy @UCBerkeley @igisci @UCSF https://t.co/ecX12bkTjX