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Mashup Score: 7Linking vaccine adjuvant mechanisms of action to function - 5 day(s) ago
We review mechanisms of action underlying the function of vaccine adjuvants and knowledge gaps to be addressed.
Source: www.science.orgCategories: General Medicine News, Allergy-ImmunologyTweet
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Mashup Score: 59IL-4 induces CD22 expression to restrain the effector program of virtual memory T cells - 9 day(s) ago
CD22 regulates IL-4–induced expansion and responsiveness of virtual memory T cells during helminth infection.
Source: www.science.orgCategories: General Medicine News, Allergy-ImmunologyTweet-
Scientists have found that virtual memory T cells upregulate the inhibitory receptor #CD22, which limits their expansion during #helminth infections in mice. @UniversiteLiege Learn more in Science #Immunology: https://t.co/QVWRyGtGLk https://t.co/5FNzdKcioE
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Mashup Score: 219Molecular determinants of cross-strain influenza A virus recognition by αβ T cell receptors - 10 day(s) ago
TCR-peptide-HLA ternary structures define molecular mechanisms of TCR cross-reactivity toward natural influenza variants.
Source: www.science.orgCategories: General Medicine News, Allergy-ImmunologyTweet-
Researchers in Science #Immunology have identified CD8+ T cells from human donors that can recognize naturally occurring influenza variants spanning more than 100 years, including the 1918 influenza A and 2024 #H5N1. @Jamie_Rossjohn @kedzierskalab https://t.co/TMj791udTM https://t.co/0A2r3HxXmb
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Mashup Score: 98Bone marrow breakout lesions act as key sites for tumor-immune cell diversification in multiple myeloma - 11 day(s) ago
Single-cell and spatial multiomics analyses identify breakout lesions as a hotspot for tumor-immune interactions and diversification.
Source: www.science.orgCategories: General Medicine News, Allergy-ImmunologyTweet-
Scientists have identified bone marrow #BreakoutLesions as hotspots for tumor-immune cell interactions, which could contribute to disease progression in patients with #MultipleMyeloma. @haas_lab @HDMyeloma @hi_stem_lab Read more in Science #Immunology: https://t.co/KQV6VOEKpf https://t.co/83kEgIuqgN
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Mashup Score: 59IL-4 induces CD22 expression to restrain the effector program of virtual memory T cells - 12 day(s) ago
CD22 regulates IL-4–induced expansion and responsiveness of virtual memory T cells during helminth infection.
Source: www.science.orgCategories: General Medicine News, Allergy-ImmunologyTweet-
Scientists have found that virtual memory T cells upregulate the inhibitory receptor #CD22, which limits their expansion during #helminth infections in mice. @UniversiteLiege Learn more in Science #Immunology: https://t.co/QVWRyGtGLk https://t.co/5FNzdKcioE
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Mashup Score: 195Molecular determinants of cross-strain influenza A virus recognition by αβ T cell receptors - 13 day(s) ago
TCR-peptide-HLA ternary structures define molecular mechanisms of TCR cross-reactivity toward natural influenza variants.
Source: www.science.orgCategories: General Medicine News, Allergy-ImmunologyTweet-
Researchers in Science #Immunology have identified CD8+ T cells from human donors that can recognize naturally occurring influenza variants spanning more than 100 years, including the 1918 influenza A and 2024 #H5N1. @Jamie_Rossjohn @kedzierskalab https://t.co/TMj791udTM https://t.co/0A2r3HxXmb
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Mashup Score: 97Bone marrow breakout lesions act as key sites for tumor-immune cell diversification in multiple myeloma - 14 day(s) ago
Single-cell and spatial multiomics analyses identify breakout lesions as a hotspot for tumor-immune interactions and diversification.
Source: www.science.orgCategories: General Medicine News, Allergy-ImmunologyTweet-
Scientists have identified bone marrow #BreakoutLesions as hotspots for tumor-immune cell interactions, which could contribute to disease progression in patients with #MultipleMyeloma. @haas_lab @HDMyeloma @hi_stem_lab Read more in Science #Immunology: https://t.co/KQV6VOEKpf https://t.co/83kEgIuqgN
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Mashup Score: 101Contents | Science Immunology 10, 104 - 15 day(s) ago
ONLINE COVER Immune Hotspots in Multiple Myeloma. Multiple myeloma (MM) is a plasma cell malignancy that develops in the bone marrow but can expand as breakout lesions into neighboring soft tissues as the disease progresses. Using single-cell and spatial multiomics, Lutz et al. compared the cellular composition of bone marrow–confined MM and breakout lesions in patients with newly diagnosed MM. Within breakout lesions, “immune islands” containing focal accumulation of immune cells served as sites for T
Source: www.science.orgCategories: General Medicine News, Allergy-ImmunologyTweet-
Science #Immunology's February issue is out! The cover depicts hotspots of tumor-immune cell interactions within #BreakoutLesions in patients with #MultipleMyeloma, which could contribute to disease progression. Learn more in this month's issue: https://t.co/Dwjj1XEqMM https://t.co/phzlKKlYPa
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Mashup Score: 275Trogocytosis of chimeric antigen receptors between T cells is regulated by their transmembrane domains - 17 day(s) ago
Chimeric antigen receptor trogocytosis transfers antitumor immunity between T cells and is dictated by their transmembrane domain.
Source: www.science.orgCategories: General Medicine News, Allergy-ImmunologyTweet-
Researchers have demonstrated that #CARTcells can transfer tumor-specific receptors to T cells in mice via #trogocytosis, endowing recipient cells with antitumor immunity. @UU_University Read more in Science #Immunology: https://t.co/KDdfundeoJ https://t.co/hPnYzvNbbX
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Mashup Score: 172Proximity-dependent labeling identifies dendritic cells that drive the tumor-specific CD4+ T cell response - 18 day(s) ago
This study characterizes the dendritic cells that present antigen to tumor-specific CD4+ T cells in the tumor and tumor-draining lymph node.
Source: www.science.orgCategories: General Medicine News, Allergy-ImmunologyTweet-
A Science #Immunology from last year highlights how LIPSTIC, a proximity-based labeling method, can identify antigen-presenting #DendriticCells that activate CD4+ #TCells in tumors and tumor-draining lymph nodes in mice. https://t.co/y1rqq6hYln #WorldCancerDay https://t.co/gSuiIAKKKA
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A new Science #Immunology Review discusses how #vaccine #adjuvants function and highlight knowledge gaps that need to be addressed to develop improved vaccines against emerging pathogens. @kochinstitute @MITdeptofBE @scrippsresearch https://t.co/6wT9DAgf0B https://t.co/ejPuEgtOXr