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Mashup Score: 7
Targeting TIM-3 palmitoylation mediated by DHHC9 enhances CAR-T cell– and NK cell–based tumor immunotherapy by suppressing immune exhaustion.
Source: www.science.orgCategories: General Medicine News, Allergy-ImmunologyTweet
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Mashup Score: 43A tetraspecific engager armed with a non-alpha IL-2 variant harnesses natural killer cells against B cell non-Hodgkin lymphoma - 3 day(s) ago
IPH6501, a CD20-targeted NK cell engager armed with non-alpha IL-2, shows preclinical efficacy and tolerability in B-NHL.
Source: www.science.orgCategories: General Medicine News, Allergy-ImmunologyTweet-
New preclinical research from @EricVivier1 highlights the promise of #NaturalKillerCell engagers that induce antitumor activity against B cell non-Hodgkin #lymphoma. @DemariaO More in Science #Immunology: https://t.co/ZrkBnYnWsw https://t.co/jI0azWJbuz
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Mashup Score: 76The pore-forming apolipoprotein APOL7C drives phagosomal rupture and antigen cross-presentation by dendritic cells - 12 day(s) ago
The apolipoprotein APOL7C is recruited to phagosomes to deliver engulfed antigens to the cytosol for cross-presentation by cDCs.
Source: www.science.orgCategories: General Medicine News, Allergy-ImmunologyTweet-
New research in Science #Immunology identifies the pore-forming protein #APOL7C as a driver of phagosomal rupture and antigen cross-presentation in activated dendritic cells. @CantonJohnathan @GeroneGon @Liam_Wilki @_Cassie_Wood https://t.co/ySI46DLlrn https://t.co/C6B6AbyTG3
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Mashup Score: 63Kupffer cell reverse migration into the liver sinusoids mitigates neonatal sepsis and meningitis - 13 day(s) ago
Restricted access of Kupffer cells to the bloodstream in newborns is linked to increased systemic bacterial infections and higher mortality.
Source: www.science.orgCategories: General Medicine News, Allergy-ImmunologyTweet-
New research from @Kubes_Lab suggests that delayed migration of #Kupffer cells into the liver’s blood vessels increases susceptibility to bloodstream bacterial infections in #newborns. @brunaraujodavid Learn more in Science #Immunology: https://t.co/wgxWLgLvGn https://t.co/FUxiIjKCNa
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Mashup Score: 75The pore-forming apolipoprotein APOL7C drives phagosomal rupture and antigen cross-presentation by dendritic cells - 14 day(s) ago
The apolipoprotein APOL7C is recruited to phagosomes to deliver engulfed antigens to the cytosol for cross-presentation by cDCs.
Source: www.science.orgCategories: General Medicine News, Allergy-ImmunologyTweet-
New research in Science #Immunology identifies the pore-forming protein #APOL7C as a driver of phagosomal rupture and antigen cross-presentation in activated dendritic cells. @CantonJohnathan @GeroneGon @Liam_Wilki @_Cassie_Wood https://t.co/ySI46DLlrn https://t.co/C6B6AbyTG3
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Mashup Score: 63Kupffer cell reverse migration into the liver sinusoids mitigates neonatal sepsis and meningitis - 16 day(s) ago
Restricted access of Kupffer cells to the bloodstream in newborns is linked to increased systemic bacterial infections and higher mortality.
Source: www.science.orgCategories: General Medicine News, Allergy-ImmunologyTweet-
New research from @Kubes_Lab suggests that delayed migration of #Kupffer cells into the liver’s blood vessels increases susceptibility to bloodstream bacterial infections in #newborns. @brunaraujodavid Learn more in Science #Immunology: https://t.co/wgxWLgLvGn https://t.co/FUxiIjKCNa
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Mashup Score: 85Contents | Science Immunology 9, 101 - 17 day(s) ago
ONLINE COVER Delayed Deployment of Liver Macrophage Defenses. Newborns are particularly vulnerable to bloodstream bacterial infections that can lead to meningitis, but the mechanisms underlying this susceptibility are not fully understood. Araujo David et al. found that Kupffer cells (KCs)—specialized liver macrophages responsible for bacterial clearance from the bloodstream—relocate from the liver parenchyma to the sinusoids during the first week of life. The relocalization of KCs conferred mice with
Source: www.science.orgCategories: General Medicine News, Allergy-ImmunologyTweet-
Science #Immunology's November issue is out! This month's cover highlights new research that suggests that delayed relocation of liver macrophages, or #KupfferCells, into blood vessels underlies newborns' susceptibility to bloodstream infections. https://t.co/JJCWSt6Efe https://t.co/FrW6ydWMYD
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Mashup Score: 108
We describe a structure of adenoviral E3/49K complexed with CD45, which provides a mechanistic blueprint for engineering T cell immunomodulators.
Source: www.science.orgCategories: General Medicine News, Allergy-ImmunologyTweet-
New research from @Stanford_MCP describes the structural mechanism that enables #adenoviruses to escape immunity by targeting #CD45 on T cells. Read more in Science #Immunology: https://t.co/aLy45wPKRP https://t.co/JZc67v23mw
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Mashup Score: 94Gastrointestinal germinal center B cell depletion and reduction in IgA+ plasma cells in HIV-1 infection - 20 day(s) ago
Intestinal germinal center B cell reduction in HIV-1 infection is linked to reduced IgA+ plasma cells and systemic inflammation.
Source: www.science.orgCategories: General Medicine News, Allergy-ImmunologyTweet-
New research from @MehandruLab describes the depletion of germinal center B cells and IgA+ plasma cells in the #GI tracts of people living with #HIV. @francescacossa1 Read more in Science #Immunology: https://t.co/AddkkyWKbD https://t.co/ToZkXMpm8N
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Mashup Score: 106
We describe a structure of adenoviral E3/49K complexed with CD45, which provides a mechanistic blueprint for engineering T cell immunomodulators.
Source: www.science.orgCategories: General Medicine News, Allergy-ImmunologyTweet-
New research from @Stanford_MCP describes the structural mechanism that enables #adenoviruses to escape immunity by targeting #CD45 on T cells. Read more in Science #Immunology: https://t.co/aLy45wPKRP https://t.co/JZc67v23mw
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New preclinical research reveals that #palmitoylation of the immune checkpoint protein #TIM3 prevents its degradation and leads to immune exhaustion and impaired antitumor activity. More in Science #Immunology: https://t.co/AdG8YsFcgG https://t.co/3mjpXlFv63