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Mashup Score: 16Targeted depletion of PD-1–expressing cells induces immune tolerance through peripheral clonal deletion - 15 hour(s) ago
Targeting PD-1+ cells promotes immune tolerance via peripheral clonal deletion of antigen-specific T cells.
Source: www.science.orgCategories: General Medicine News, Allergy-ImmunologyTweet
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Mashup Score: 66TIM-3+ CD8 T cells with a terminally exhausted phenotype retain functional capacity in hematological malignancies - 3 day(s) ago
A subset of CD8 T cells with a terminally exhausted epigenetic profile expressed IFN-γ, granzymes, and perforin in bone marrow.
Source: www.science.orgCategories: General Medicine News, Allergy-ImmunologyTweet
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Mashup Score: 114Gut-associated lymphoid tissue attrition associates with response to anti-α4β7 therapy in ulcerative colitis - 4 day(s) ago
Targeting of GALT by anti-α4β7 therapy is associated with therapeutic responses in ulcerative colitis.
Source: www.science.orgCategories: General Medicine News, Allergy-ImmunologyTweet
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Mashup Score: 65TIM-3+ CD8 T cells with a terminally exhausted phenotype retain functional capacity in hematological malignancies - 5 day(s) ago
A subset of CD8 T cells with a terminally exhausted epigenetic profile expressed IFN-γ, granzymes, and perforin in bone marrow.
Source: www.science.orgCategories: General Medicine News, Allergy-ImmunologyTweet
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Mashup Score: 80Allogeneic double-negative CAR-T cells inhibit tumor growth without off-tumor toxicities - 6 day(s) ago
Allogeneic CAR-DNTs with minimal genetic modification show potent anti-tumor activity without off-tumor toxicities.
Source: www.science.orgCategories: General Medicine News, Allergy-ImmunologyTweet
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Mashup Score: 132
Spatially resolved profiling of the melanoma microenvironment reveals correlates of response to immune checkpoint inhibitors.
Source: www.science.orgCategories: General Medicine News, Allergy-ImmunologyTweet
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Mashup Score: 113Gut-associated lymphoid tissue attrition associates with response to anti-α4β7 therapy in ulcerative colitis - 8 day(s) ago
Targeting of GALT by anti-α4β7 therapy is associated with therapeutic responses in ulcerative colitis.
Source: www.science.orgCategories: General Medicine News, Allergy-ImmunologyTweet
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Mashup Score: 18Genome-wide screening identifies Trim33 as an essential regulator of dendritic cell differentiation - 10 day(s) ago
The transcriptional regulator Trim33 controls Flt3L-driven dendritic cell differentiation.
Source: www.science.orgCategories: General Medicine News, Allergy-ImmunologyTweet
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Mashup Score: 168
Division of labor among resident tissue macrophages is vital for proper tissue function during homeostasis.
Source: www.science.orgCategories: General Medicine News, Allergy-ImmunologyTweet
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Mashup Score: 15Genome-wide screening identifies Trim33 as an essential regulator of dendritic cell differentiation - 12 day(s) ago
The transcriptional regulator Trim33 controls Flt3L-driven dendritic cell differentiation.
Source: www.science.orgCategories: General Medicine News, Allergy-ImmunologyTweet
A depletion of #PD1-expressing #Tcells in mouse models prevents heart transplant rejection and could facilitate transplant immune tolerance. @HuazhongUST Learn more: https://t.co/3hpnZTn8k8 https://t.co/KY9gS2TgvU