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γδ T cells are important for responding to immune checkpoint blockade therapy in patients whose cancers have downregulated MHC class I...

In addition to their well-established role in haemostasis, platelets also have an active role in the immune response. Here the authors summarize the evidence...

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Science Immunology

Contents | Science Immunology 8, 80 - 22 hours

Mashup Score:92

Science Immunology Volume 8|Issue 80|Feb 2023 ONLINE COVER Tumor-infiltrating Lymphocytes on JET Patrol. This month’s cover depicts T lymphocytes specific for tumor neoantigens near...

How tissue-specific mechanisms shape anti-tumor immunity remains poorly understood. Zagorulya et al. reveal that lung lymph node (LN)-specific abundance of interferon-gamma induces suppressive Th1-like effector...

Ribosome biogenesis, including ribosomal RNA (rRNA) production, occurs in the nucleolus. Recent studies have revealed how the integrity and copy number of rRNA genes...

Granulomas are accumulations of immune cells that help contain infections but can also give rise to diseases. To better understand granuloma formation, Krausgruber et al....

Key Points. Androgen deprivation therapy results in increased recent thymic emigrants (RTEs).RTEs traffic to prostate tumors.RTEs become activated and produce...

Abstract. Macrophages are sentinels of the innate immune system that maintain tissue homeostasis and contribute to inflammatory responses. Their broad scope...

Cancer immunotherapy has radically changed the natural history of many malignancies and is currently standard of care in several diseases. Different monoclonal antibodies blocking...

Distinguishing between commensal and pathogenic bacteria to generate appropriate responses (tolerance vs. immunogenicity) is a key decision that the human immune system must make...