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Mashup Score: 2ASHG Spotlight: Equity in early career research: Human Genetics and Genomics Advances - 2 hour(s) ago
Read interviews with seven early career researchers, published in ASHG journals American Journal of Human Genetics and HGG Advances, who describe their career journeys, roadblocks, tips for success, motivations, and their vision for a more equitable future for scientists starting out on their research careers. Baylor College of Medicine, USA University of Minnesota Twin Cities, USA Could you please give a short introduction and bio of yourself? I am an assistant professor in the Department of Molecular
Source: www.cell.comCategories: General Medicine News, General HCPsTweet
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Mashup Score: 1Creating connections when we talk about science - 3 hour(s) ago
For Cell’s 50th anniversary Focus on Immunology, scientific editor Cheri Sirois asked science communicator Liz Neeley, founding partner of Liminal and cofounder of Solving for Science, to discuss strategies for tackling technical complexity and for engaging effectively with broad audiences. A lightly edited transcript of their conversation is shared here.
Source: www.cell.comCategories: General Medicine News, General HCPsTweet
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Mashup Score: 57
Pyroptosis is a form of signaling-induced cell death characterized by plasma membrane rupture. This study suggests a “cookie cutter”-like mechanism for pyroptotic cell lysis in which oligomerization of the protein NINJ1 punches holes out of the plasma membrane and liberates “cookie”-like disks.
Source: www.cell.comCategories: General Medicine News, General HCPsTweet
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Mashup Score: 55RNA genome packaging and capsid assembly of bluetongue virus visualized in host cells - 18 hour(s) ago
Integrated structural analyses captured a total of eleven assembly states of bluetongue virus (BTV), revealing insights into the mysterious RNA packaging and capsid assembly of dsRNA viruses.
Source: www.cell.comCategories: General Medicine News, General HCPsTweet
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Mashup Score: 80
An inhibitory ligand acts directly on CD3e to regulate T cell activation, and disruption of the interaction boosts tumor-specific T cell cytotoxicity to limit tumor growth.
Source: www.cell.comCategories: General Medicine News, General HCPsTweet
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Mashup Score: 11A pan-cancer analysis of the microbiome in metastatic cancer - 23 hour(s) ago
Characterization of microbiome genomes at the species level in over 4,000 metastatic tumor biopsies identifies the distribution and diversity features of tumor-resident bacterial DNA at a pan-cancer scale, highlighting the associations between microbial community dynamics and tumor immunity and immunotherapy efficacy.
Source: www.cell.comCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 25
Histone deacetylases (HDACs) are important chromatin regulators essential for plant tolerance to adverse environments. In addition to histone deacetylation and epigenetic regulation, HDACs deacetylate non-histone proteins and thereby regulate multiple pathways. Like other post-translational modifications (PTMs), acetylation/deacetylation is a reversible switch regulating different cellular processes in plants. Here, by focusing on results obtained in arabidopsis (Arabidopsis thaliana) and rice plants, we analyze the different aspects of HDAC functions and the underlying regulatory mechanisms in modulating plant responses to stress.
Source: www.cell.comCategories: General Medicine News, General HCPsTweet
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Mashup Score: 61
Cells carrying a monoallelic germline BRCA2 mutation can bypass Knudson’s “two-hit” requirement to initiate tumorigenesis when the glycolytic metabolite methylglyoxal transiently disables BRCA2 function. Metabolic bypass of tumor suppressor activity may link metabolic reprogramming, metabolic disorders, or diet to early steps in carcinogenesis.
Source: www.cell.comCategories: General Medicine News, General HCPsTweet
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Mashup Score: 11A pan-cancer analysis of the microbiome in metastatic cancer - 1 day(s) ago
Characterization of microbiome genomes at the species level in over 4,000 metastatic tumor biopsies identifies the distribution and diversity features of tumor-resident bacterial DNA at a pan-cancer scale, highlighting the associations between microbial community dynamics and tumor immunity and immunotherapy efficacy.
Source: www.cell.comCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 110
Expansion microscopy and time-series reconstructions enable elaboration of dynamic centriole assembly.
Source: www.cell.comCategories: General Medicine News, General HCPsTweet
Read insights from early career researchers on their roadblocks, motivations and vision for #ECR equity https://t.co/mv7ljdT44K ASHG Spotlight: Equity in early career research @GeneticsSociety @ajhgnews and @HGGAdvances https://t.co/PUr7Ea6eq8