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Mashup Score: 6An age-progressive platelet differentiation path from hematopoietic stem cells causes exacerbated thrombosis - 2 hour(s) ago
With advanced age, platelets generated by a differentiation pathway that shortcuts the canonical progenitor cascade to directly make megakaryotic precursor cells from hematopoietic stem cells cause thrombocytosis and are more prone to thrombosis compared with canonically derived platelets.
Source: www.cell.comCategories: General Medicine News, General Journals & SocietTweet
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Mashup Score: 16
Intraepithelial mast cells (IEMCs) were first observed 105 years ago, yet their functions remain enigmatic. Yang et al. reveal that IEMCs are required for epithelial gasdermin C activation and IEMC-epithelium crosstalk constitutes a critical step in type 2 immune responses.
Source: www.cell.comCategories: General Medicine News, Allergy-ImmunologyTweet
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Mashup Score: 10Molecular targets of glucocorticoids that elucidate their therapeutic efficacy in aggressive lymphomas - 2 hour(s) ago
For more than 70 years, glucocorticoids have been known to have clinical activity against lymphoid but not myeloma malignancies. Choi et al. resolve this conundrum by demonstrating that glucocorticoids kill lymphomas by inhibiting BCR signaling. These mechanistic insights enable rational combination of glucocorticoids with other targeted agents in anti-lymphoma regimens.
Source: www.cell.comCategories: General Medicine News, Onc News and JournalsTweet
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Mashup Score: 1Plp1-expresssing perineuronal DRG cells facilitate colonic and somatic chronic mechanical pain involving Piezo2 upregulation in DRG neurons - 2 hour(s) ago
Tiwari et al. reveal that Plp1+ satellite glial cells (SGCs) of dorsal root ganglia facilitate chronic colonic and somatic mechanical pain, in which activated SGCs release mediators to activate neurons that sense pain.
Source: www.cell.comCategories: General Medicine News, General HCPsTweet
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Mashup Score: 5Stem Cell Reports | Cell Press - 3 hour(s) ago
At Stem Cell Reports we recognize common constraints that may prevent in-depth investigations needed for a full research article. We also understand the need to swiftly publish your research as an integral part of your career development. We are pleased to highlight the Stem Cell Reports “Report” paper format that enables you to publish novel findings in a concise and timely manner. Learn more “We encourage authors who have interesting discoveries they want to publish quickly to consider our Reports
Source: www.cell.comCategories: General Medicine News, General NewsTweet
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Mashup Score: 0An age-progressive platelet differentiation path from hematopoietic stem cells causes exacerbated thrombosis - 3 hour(s) ago
With advanced age, platelets generated by a differentiation pathway that shortcuts the canonical progenitor cascade to directly make megakaryotic precursor cells from hematopoietic stem cells cause thrombocytosis and are more prone to thrombosis compared with canonically derived platelets.
Source: www.cell.comCategories: General Medicine News, NeurologyTweet
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Mashup Score: 2Perivascular neurons instruct 3D vascular lattice formation via neurovascular contact - 3 hour(s) ago
Perivascular neurons guide the spatial orientation of penetrating vessels via Piezo2 to pattern the 3D vascular lattice in the developing mouse retina. This neuron-guided vascular patterning is critical for capillary perfusion of the retina and protection from ischemic challenge, progressive retinal neuron loss, and visual impairment.
Source: www.cell.comCategories: General Medicine News, NeurologyTweet
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Mashup Score: 0An age-progressive platelet differentiation path from hematopoietic stem cells causes exacerbated thrombosis - 3 hour(s) ago
With advanced age, platelets generated by a differentiation pathway that shortcuts the canonical progenitor cascade to directly make megakaryotic precursor cells from hematopoietic stem cells cause thrombocytosis and are more prone to thrombosis compared with canonically derived platelets.
Source: www.cell.comCategories: General Medicine News, NeurologyTweet
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Mashup Score: 12The adipose-neural axis is involved in epicardial adipose tissue-related cardiac arrhythmias - 4 hour(s) ago
Fan et al. establish a stem cell-based coculture model to mimic the in vivo cardiac microenvironment and elucidate that the adipose-neural interaction plays a critical role in epicardial adipose tissue-related cardiac arrhythmia through leptin-NPY axis. Their results may provide potential therapeutic targets for treating arrhythmia.
Source: www.cell.comCategories: General Medicine News, Expert PicksTweet
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Mashup Score: 30Type I interferons induce an epigenetically distinct memory B cell subset in chronic viral infection - 5 hour(s) ago
Chronic viral infection disrupts the ability to form long-lived B cell-mediated protective immunity, but the mechanisms are unclear. Cooper et al. demonstrate a key role of type I interferon (IFN-I) in governing memory B cell identity and show that the chromatin landscape and phenotype of memory B cells are set during a critical early window of IFN-I exposure.
Source: www.cell.comCategories: General Medicine News, Allergy-ImmunologyTweet
Now online! An age-progressive platelet differentiation path from hematopoietic stem cells causes exacerbated thrombosis https://t.co/KEhkTGRzrT