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    • Mashup Score: 675
      The Gut-Brain Axis Takes Center Stage - 3 day(s) ago

      A rapid expansion of new discoveries and knowledge lays the foundation for a new era in medicine

      Source: erictopol.substack.com
      Categories: General Medicine News, Expert Picks
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      • Profile photo of 	EricTopol
        EricTopol

        Spotlight on the gut-brain axis A rapid expansion of new discoveries and knowledge lays the foundation for a new era in medicine https://t.co/cEBEgcUwia https://t.co/Aih2gK9Tac

    • Mashup Score: 59
      The Drivers of Age-Related Diseases - 3 day(s) ago

      New insights on the pivotal role of Immunosenescence and Inflammaging

      Source: erictopol.substack.com
      Categories: General Medicine News, Expert Picks
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      • Profile photo of 	EricTopol
        EricTopol

        Link https://t.co/lTwyNrHxU8

    • Mashup Score: 62
      Study Suggests Weight-Loss Pill is as Effective as Ozempic (Gift Article) - 3 day(s) ago

      The drugs in development include a pill that a new trial suggests is about as effective as Ozempic.

      Source: www.nytimes.com
      Categories: General Medicine News, Expert Picks
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      • Profile photo of 	EricTopol
        EricTopol

        The number of new gut hormone related drugs and their combinations are exploding, with effects far beyond improved glucose regulation and weight loss. We'll look back at semaglutide (Ozempic) as just the beginning https://t.co/fEbwMrH8xo

    • Mashup Score: 37
      People With Severe Diabetes Are Cured in Small Trial of New Drug (Gift Article) - 4 day(s) ago

      Most in a small group of patients receiving a stem cell-based infusion no longer needed insulin, but the drug may not suit those with more manageable type 1 diabetes.

      Source: www.nytimes.com
      Categories: General Medicine News, Expert Picks
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      • Profile photo of 	EricTopol
        EricTopol

        "Cured" That's not yet established. https://t.co/XQi9DiimbW

    • Mashup Score: 587
      Amycretin, a novel, unimolecular GLP-1 and amylin receptor agonist administered subcutaneously: results from a phase 1b/2a randomised controlled study - 4 day(s) ago

      In people with overweight or obesity, once-weekly subcutaneous amycretin up to 60 mg had a safety and tolerability profile consistent with GLP-1 and amylin agonists. Although a high frequency of gastrointestinal events was reported, rates were similar to those seen in early-phase studies of these molecules. These results support further investigation into the weight loss properties of amycretin.

      Source: www.thelancet.com
      Categories: General Medicine News, Expert Picks
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      • Profile photo of 	EricTopol
        EricTopol

        The GLP-1 drugs (Ozempic and descendants) were just the beginning of a new gut hormone era in medicine Here's Amycretin (oral and injectable), a dual agonist (GLP-1 and Amylin) @TheLancet @AmDiabetesAssn #ADASciSessions https://t.co/GbHypeTty9 https://t.co/oxEAwRktT0

    • Mashup Score: 220
      Sitting–rising test scores predict natural and cardiovascular causes of deaths in middle-aged and older men and women - 5 day(s) ago

      AbstractAims. In a previous study, the ability to sit and rise from the floor was associated with all-cause mortality. Now, we aim to assess whether sittin

      Source: academic.oup.com
      Categories: General Medicine News, Expert Picks
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      • Profile photo of 	EricTopol
        EricTopol

        Sitting-rising test scores and all-cause, cardiovascular mortality in >4,000 participants aged 46-75 followed for 12 years https://t.co/VwKhI98bxL https://t.co/k8qTPKHN9f

    • Mashup Score: 65
      New approach enables body to engineer its own cells to fight cancer or autoimmunity - 5 day(s) ago

      Injections of mRNA may offer a simpler, cheaper way to build powerful CAR-T cells

      Source: www.science.org
      Categories: General Medicine News, Expert Picks
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      • Profile photo of 	EricTopol
        EricTopol

        Good explainer for this important advance @ScienceMagazine https://t.co/H3yokZZrpn

    • Mashup Score: 488
      Neuroinflammation across neurological diseases - 5 day(s) ago

      The brain’s response to injury includes the activation of intrinsic microglia and the influx of leukocytes, collectively constituting neuroinflammation, the “flame” of the brain. Although details differ and matter, neuroinflammation exacerbating …

      Source: www.science.org
      Categories: General Medicine News, Expert Picks
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      • Profile photo of 	EricTopol
        EricTopol

        Inflammation in the brain can be beneficial or pathogenic. It varies across neurological diseases. And many new ways are emerging to modulate it An outstanding new review @ScienceMagazine https://t.co/R6AEcg80xj https://t.co/Jg0weU2I2a

    • Mashup Score: 43
      Michelle Monje: The Brain in Long Covid and Cancer - 5 day(s) ago

      Listen now (44 mins) |

      Source: erictopol.substack.com
      Categories: General Medicine News, Expert Picks
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      • Profile photo of 	EricTopol
        EricTopol

        Our conversation on this exceptional work https://t.co/5qyg5NyCAB https://t.co/xKM7A2Cw2r

    • Mashup Score: 342
      Michelle Monje: co-pioneer of cancer neuroscience - 5 day(s) ago

      Michelle Monje is the Milan Gambhir Professor of Pediatric Neuro-Oncology at Stanford University, CA, USA, and a Howard Hughes Medical Institute Investigator. In March, 2025, she won the prestigious Lundbeck Foundation’s Brain Prize for co-pioneering the field of cancer neuroscience with Heidelberg University’s Frank Winkler. “Cancer neuroscience is a field that seeks to understand and therapeutically target interactions between the nervous system and cancer”, Monje explains. So “how the nervous system promotes or regulates the growth, invasion, and treatment resistance of a wide range of cancers…and then conversely, how cancers and their therapies influence the nervous system”.

      Source: www.thelancet.com
      Categories: General Medicine News, Expert Picks
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      • Profile photo of 	EricTopol
        EricTopol

        The pioneer of cancer neuroscience, @michelle_monje, w/ Frank Winkler @BrainPrize, profiled @TheLancet today @Stanford @StanfordMed @KarlDeisseroth https://t.co/8C5bJYKo1N https://t.co/B3lrJzWOFj

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    Eric Topol

    @EricTopol

    physician-scientist, author, editor. My new book is #DeepMedicine https://t.co/2cGuSrDye3

    ASCO 2025

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