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Mashup Score: 78Effect of exercise for depression: systematic review and network meta-analysis of randomised controlled trials - 1 hour(s) ago
Objective To identify the optimal dose and modality of exercise for treating major depressive disorder, compared with psychotherapy, antidepressants, and control conditions. Design Systematic review and network meta-analysis. Methods Screening, data extraction, coding, and risk of bias assessment were performed independently and in duplicate. Bayesian arm based, multilevel network meta-analyses were performed for the primary analyses. Quality of the evidence for each arm was graded using the confidence in network meta-analysis (CINeMA) online tool. Data sources Cochrane Library, Medline, Embase, SPORTDiscus, and PsycINFO databases. Eligibility criteria for selecting studies Any randomised trial with exercise arms for participants meeting clinical cut-offs for major depression. Results 218 unique studies with a total of 495 arms and 14 170 participants were included. Compared with active controls (eg, usual care, placebo tablet), moderate reductions in depression were found for walking
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Mashup Score: 6Association of ultra-processed food consumption with all cause and cause specific mortality: population based cohort study - 2 hour(s) ago
Objective To examine the association of ultra-processed food consumption with all cause mortality and cause specific mortality. Design Population based cohort study. Setting Female registered nurses from 11 US states in the Nurses’ Health Study (1984-2018) and male health professionals from all 50 US states in the Health Professionals Follow-up Study (1986-2018). Participants 74 563 women and 39 501 men with no history of cancer, cardiovascular diseases, or diabetes at baseline. Main outcome measures Multivariable Cox proportional hazard models were used to estimate hazard ratios and 95% confidence intervals for the association of ultra-processed food intake measured by semiquantitative food frequency questionnaire every four years with all cause mortality and cause specific mortality due to cancer, cardiovascular, and other causes (including respiratory and neurodegenerative causes). Results 30 188 deaths of women and 18 005 deaths of men were documented during a median of 34 and 31 y
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Mashup Score: 48Association of ultra-processed food consumption with all cause and cause specific mortality: population based cohort study - 9 hour(s) ago
Objective To examine the association of ultra-processed food consumption with all cause mortality and cause specific mortality. Design Population based cohort study. Setting Female registered nurses from 11 US states in the Nurses’ Health Study (1984-2018) and male health professionals from all 50 US states in the Health Professionals Follow-up Study (1986-2018). Participants 74 563 women and 39 501 men with no history of cancer, cardiovascular diseases, or diabetes at baseline. Main outcome measures Multivariable Cox proportional hazard models were used to estimate hazard ratios and 95% confidence intervals for the association of ultra-processed food intake measured by semiquantitative food frequency questionnaire every four years with all cause mortality and cause specific mortality due to cancer, cardiovascular, and other causes (including respiratory and neurodegenerative causes). Results 30 188 deaths of women and 18 005 deaths of men were documented during a median of 34 and 31 y
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Mashup Score: 294How Bad Are Ultraprocessed Foods, Really? - 10 hour(s) ago
They’re clearly linked to poor health. But scientists are only beginning to understand why.
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Mashup Score: 147The Science Behind Food and Dangers of Ultra-Processed, Artificial, Non-Food with Dr. Chris Van Tulleken - 10 hour(s) ago
Listen now (47 mins) |
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Mashup Score: 1087Hacking the immune system could slow ageing — here’s how - 13 hour(s) ago
Nature – Our immune system falters over time, which could explain the negative effects of ageing.
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Mashup Score: 110
Local capacity should be prioritized for gene therapies that combat diseases prevalent in low- and middle-income countries.
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Mashup Score: 3188Covid-19 vaccine effectiveness against post-covid-19 condition among 589 722 individuals in Sweden: population based cohort study - 15 hour(s) ago
Objective To investigate the effectiveness of primary covid-19 vaccination (first two doses and first booster dose within the recommended schedule) against post-covid-19 condition (PCC). Design Population based cohort study. Setting Swedish Covid-19 Investigation for Future Insights—a Population Epidemiology Approach using Register Linkage (SCIFI-PEARL) project, a register based cohort study in Sweden. Participants All adults (≥18 years) with covid-19 first registered between 27 December 2020 and 9 February 2022 (n=589 722) in the two largest regions of Sweden. Individuals were followed from a first infection until death, emigration, vaccination, reinfection, a PCC diagnosis (ICD-10 diagnosis code U09.9), or end of follow-up (30 November 2022), whichever came first. Individuals who had received at least one dose of a covid-19 vaccine before infection were considered vaccinated. Main outcome measure The primary outcome was a clinical diagnosis of PCC. Vaccine effectiveness against PCC w
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Mashup Score: 530
Nature – Accurate structure prediction of biomolecular interactions with AlphaFold 3
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Mashup Score: 333Effects of a personalized nutrition program on cardiometabolic health: a randomized controlled trial - 19 hour(s) ago
Nature Medicine – A randomized controlled trial showed that following a personalized dietary program led to significant improvements in cardiometabolic and gut health as well as reductions in body…
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An effective treatment for depression from a systematic review of >200 unique RCTs: Exercise Benefit proportional to intensity of exercise prescribed https://t.co/gvj7IdqN49 @bmj_latest @mnoetel @UQPsych https://t.co/1FMKWjVgiV