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Mashup Score: 8
In this report we assess who pays for cooperation in global health through an analysis of the financial flows of WHO, the World Bank, the Global Fund to Fight HIV/AIDS, TB and Malaria, and Gavi, the Vaccine Alliance. The past few decades have seen the consolidation of influence in the disproportionate roles the USA, UK, and the Bill & Melinda Gates Foundation have had in financing three of these four institutions. Current financing flows in all four case study institutions allow donors to finance and deliver assistance in ways that they can more closely control and monitor at every stage.
Source: www.thelancet.comCategories: General Medicine News, General HCPsTweet
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Mashup Score: 1423Definition and diagnostic criteria of clinical obesity - 12 hour(s) ago
Current BMI-based measures of obesity can both underestimate and overestimate adiposity and provide inadequate information about health at the individual level, which undermines medically-sound approaches to health care and policy. This Commission sought to define clinical obesity as a condition of illness that, akin to the notion of chronic disease in other medical specialties, directly results from the effect of excess adiposity on the function of organs and tissues. The specific aim of the Commission was to establish objective criteria for disease diagnosis, aiding clinical decision making and prioritisation of therapeutic interventions and public health strategies.
Source: www.thelancet.comCategories: General Medicine News, Expert PicksTweet-
This has been needed for a long time! Redefining obesity A new report of @TheLancetEndo commission that overrides current BMI categories and better defines features and pathophysiologic consequences of pre-clinical and clinical obesity https://t.co/onJhZXoL5a open-access (such as… https://t.co/Vra8cOt82D https://t.co/y5W9ylX9Pq
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Mashup Score: 3
New pathogenesis-based therapeutics and evidence-based consensus treatment recommendations, often with predefined treatment goals, have remarkably improved outcomes across many chronic diseases. However, a clinically significant subgroup of patients responds poorly to interventions and show a progressive decline in the disease trajectory, which poses an increasing health-care challenge. Difficult-to-treat approaches exist in several areas of medicine and the need for similar definitions has recently also emerged in rheumatology.
Source: www.thelancet.comCategories: General Medicine News, RheumatologyTweet-
NEW REVIEW—György Nagy and colleagues discuss the concept of difficult-to-treat disease in rheumatology https://t.co/KCqzqIFrQE @IainBMcInnes1 https://t.co/uxClj96HFP
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Mashup Score: 17Anyone can drown. No one should. - 14 hour(s) ago
“Anyone can drown. No one should.” notes WHO Director General Tedros Adhanom Ghebreyesus, in his foreword to the first WHO Global status report on drowning prevention, released on Dec 13, 2024. Following on from the recommendations of the UN resolution on drowning prevention, championed by the Governments of Bangladesh and Ireland and the 2023 World Health Assembly resolution on accelerating action on global drowning prevention, this landmark report dissects the drowning burden globally, at the country level, and the trends since 2000, presents an overview of the key strategies to prevent drowning, and provides a benchmark for tracking prevention efforts in the future.
Source: www.thelancet.comCategories: General Medicine News, General HCPsTweet-
"Anyone can drown. No one should." Drowning is a tragic, neglected, and preventable public health issue causing 300,000 deaths globally each year. "Inaction is unacceptable", say Editors in @TheLancetPH's latest Editorial: https://t.co/qTI6fmE9W1
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Mashup Score: 92
For over a century, radiotherapy has revolutionised cancer treatment. Technological advancements aim to deliver high doses to tumours with increased precision while minimising off-target effects to organs at risk. Despite advancements such as image-guided, high-precision radiotherapy delivery, long-term toxic effects on healthy tissues remain a great clinical challenge. In this Review, we summarise common mechanisms driving acute and long-term side-effects and discuss monitoring strategies for radiotherapy survivors.
Source: www.thelancet.comCategories: General Medicine News, General HCPsTweet-
For over a century, radiotherapy has revolutionised cancer treatment. However, long-term toxic effects on healthy tissues remain a great clinical challenge. New Review—Radiotherapy toxicities: mechanisms, management, and future directions: https://t.co/t45Y4eKKaq https://t.co/YTntieB6pX
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Mashup Score: 162Male hypogonadism: pathogenesis, diagnosis, and management - 17 hour(s) ago
Organic male hypogonadism due to irreversible hypothalamic–pituitary–testicular (HPT) pathology is easily diagnosed and treated with testosterone-replacement therapy. However, controversy surrounds the global practice of prescribing testosterone to symptomatic men with low testosterone and non-gonadal factors reducing health status, such as obesity, type 2 diabetes, and ageing (ie, functional hypogonadism), but without identifiable HPT axis pathology. Health optimisation remains the gold-standard management strategy.
Source: www.thelancet.comCategories: General Medicine News, EndocrinologyTweet-
New—Male #hypogonadism: pathogenesis, diagnosis, and management https://t.co/k5ZVLagJu1 #MensHealth #testosterone https://t.co/tw6yrgD7bh
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Mashup Score: 0The STEP-HFpEF programme: advancing care at the intersections - 21 hour(s) ago
Obesity, type 2 diabetes, and heart failure are expanding global syndemics1–3 with inter-related pathophysiology. Accordingly, obesity and type 2 diabetes are highly prevalent among individuals with heart failure—especially heart failure with preserved ejection fraction (HFpEF)—and contribute to worse health-related quality of life and adverse clinical outcomes.4,5 These realities underscore the urgent need for dedicated management strategies at this high-risk intersection.
Source: www.thelancet.comCategories: General Medicine News, EndocrinologyTweet-
John W Ostrominski & Vanita R Aroda comment on: The STEP-HFpEF programme: advancing care at the intersections https://t.co/p6jx3F9TMj #semaglutide #obesity #heartfailure #T2D
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Mashup Score: 31
Semaglutide 2·4 mg improved heart failure-related symptoms and physical limitations, and reduced bodyweight in patients with obesity-related HFpEF and type 2 diabetes, all independently of baseline HbA1c, and resulted in lower rates of hypoglycaemia than placebo, despite a well controlled baseline HbA1c and broad use of concomitant glucose-lowering medications.
Source: www.thelancet.comCategories: General Medicine News, EndocrinologyTweet-
New—Semaglutide in #obesity-related #heartfailure with preserved ejection fraction & type 2 #diabetes across baseline HbA1c levels (STEP-HFpEF DM): prespecified analysis of heart failure & metabolic outcomes from a randomised, placebo-controlled trial https://t.co/UdxryZxYwo #T2D
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Mashup Score: 1423Definition and diagnostic criteria of clinical obesity - 23 hour(s) ago
Current BMI-based measures of obesity can both underestimate and overestimate adiposity and provide inadequate information about health at the individual level, which undermines medically-sound approaches to health care and policy. This Commission sought to define clinical obesity as a condition of illness that, akin to the notion of chronic disease in other medical specialties, directly results from the effect of excess adiposity on the function of organs and tissues. The specific aim of the Commission was to establish objective criteria for disease diagnosis, aiding clinical decision making and prioritisation of therapeutic interventions and public health strategies.
Source: www.thelancet.comCategories: General Medicine News, Expert PicksTweet-
This has been needed for a long time! Redefining obesity A new report of @TheLancetEndo commission that overrides current BMI categories and better defines features and pathophysiologic consequences of pre-clinical and clinical obesity https://t.co/onJhZXoL5a open-access (such as… https://t.co/Vra8cOt82D https://t.co/y5W9ylX9Pq
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Mashup Score: 39
There was no benefit and possible harm from treatment with intravenous tenecteplase. Patients with minor stroke and intracranial occlusion should not be routinely treated with intravenous thrombolysis.
Source: www.thelancet.comCategories: General Medicine News, NeurologyTweet-
Tenecteplase versus standard of care for minor ischaemic stroke with proven occlusion (TEMPO-2): a randomised, open label, phase 3 superiority trial - The Lancet https://t.co/9n0Mcagy2z
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To the journalists reaching out asking how the WHO is funded and the role of the US --> see this Lancet piece which explains the financial allocations and funding model of the WHO https://t.co/MHHVye0Qqm