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Mashup Score: 118Contribution of vaccination to improved survival and health: modelling 50 years of the Expanded Programme on Immunization - 14 hour(s) ago
Since 1974 substantial gains in childhood survival have occurred in every global region. We estimate that EPI has provided the single greatest contribution to improved infant survival over the past 50 years. In the context of strengthening primary health care, our results show that equitable universal access to immunisation remains crucial to sustain health gains and continue to save future lives from preventable infectious mortality.
Source: www.thelancet.comCategories: General Medicine News, General Journals & SocietTweet
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Mashup Score: 1
Epidermal growth factor receptor (EGFR) and its activated downstream signalling pathways play a crucial role in colorectal cancer development and progression. After four decades of preclinical, translational, and clinical research, it has been shown that blocking the EGFR signalling pathway at different molecular levels represents a fundamental therapeutic strategy for patients with metastatic colorectal cancer. Nevertheless, the efficacy of molecularly targeted therapies is inescapably limited by the insurgence of mechanisms of acquired cancer cell resistance.
Source: www.thelancet.comCategories: General Medicine News, Oncologists1Tweet
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Mashup Score: 1DNA and protein HIV vaccines: how should we mix it? - 18 hour(s) ago
The development of an effective HIV vaccine is crucial for controlling the HIV epidemic. UNAIDS estimated that there were 1·5 million new HIV infections and 650 000 deaths in 2021.1 Despite decades of vaccine research and ten phase 2b/3 clinical trials testing various vaccine concepts, a protective vaccine is still needed.2 Therefore, a return to fundamental research and testing of new concepts is necessary. This task is considerable given the number of immunogens, emerging vaccine platforms, and combinations that could be tested.
Source: www.thelancet.comCategories: General Medicine News, Infectious DiseaseTweet
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Mashup Score: 37
Both vaccine regimens were safe, warranting evaluation in larger trials.
Source: www.thelancet.comCategories: General Medicine News, Infectious DiseaseTweet
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Mashup Score: 5How clinically relevant is statin-induced diabetes? - 18 hour(s) ago
Diabetes is a common chronic disease that affects up to 10% of adults worldwide.1 People with diabetes are at high risk for a wide variety of serious health consequences including, but not limited to, myocardial infarctions, strokes, heart failure, blindness, kidney failure, lower limb amputations, cognitive impairment, and many cancers. This increased risk is independent of other risk factors, is causally related to increased plasma glucose concentrations for cardiovascular events and some of the other consequences,2,3 and doubles the risk of all-cause death.
Source: www.thelancet.comCategories: General Medicine News, EndocrinologyTweet
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Mashup Score: 1302
Statins cause a moderate dose-dependent increase in new diagnoses of diabetes that is consistent with a small upwards shift in glycaemia, with the majority of new diagnoses of diabetes occurring in people with baseline glycaemic markers that are close to the diagnostic threshold for diabetes. Importantly, however, any theoretical adverse effects of statins on cardiovascular risk that might arise from these small increases in glycaemia (or, indeed, from any other mechanism) are already accounted for in the overall reduction in cardiovascular risk that is seen with statin therapy in these trials.
Source: www.thelancet.comCategories: General Medicine News, Expert PicksTweet
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Mashup Score: 13
Implementation of mobilisation in the ICU was associated with a less than 3% chance of an adverse event occurring and was not found to increase adverse events or mortality overall, providing reassurance for clinicians about the safety of performing this intervention. Subgroup analyses did not clearly identify any specific variable of mobilisation implementation that increased harm.
Source: www.thelancet.comCategories: General Medicine News, PulmonologyTweet
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Mashup Score: 10The Lancet Microbe, August 2023, Volume 4, Issue 8, Pages e563-e656 - 20 hour(s) ago
Read the current issue of The Lancet Microbe, providing a destination for the best microbiology-focused clinical research
Source: www.thelancet.comCategories: General Medicine News, General Journals & SocietTweet
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Mashup Score: 2
Both frailty (reduced physiological reserve) and social vulnerability (scarcity of adequate social connections, support, or interaction) become more common as people age and are associated with adverse consequences. Analyses of the relationships between these constructs can be limited by the wide range of measures used to assess them. In this systematic review, we synthesised 130 observational studies assessing the association between frailty and social vulnerability, the bidirectional longitudinal relationships between constructs, and their joint associations with adverse health outcomes.
Source: www.thelancet.comCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 22Effect of population-wide screening for presymptomatic early-stage type 1 diabetes on paediatric clinical care - 21 hour(s) ago
Population-wide screening of children for presymptomatic early-stage type 1 diabetes is gaining momentum. Studies have demonstrated feasibility and acceptance, and shown that the rate of progression to clinical stage 3 diabetes is similar if islet autoantibody-positive early-stage type 1 diabetes is identified from general population or first-degree relative screening.1,2 Moreover, in conjunction with an education and follow-up package, screening significantly reduces the rates of ketoacidosis, symptoms, and hospitalisation.
Source: www.thelancet.comCategories: General Medicine News, EndocrinologyTweet
“Contribution of #vaccination to improved survival and health: modelling 50 years of the Expanded Programme on Immunization”: a new study 🔽 https://t.co/zlyx2T4xCK 👇 Figure: Deaths averted, years of life saved, and years of full health gained due to vaccination https://t.co/6QW4z29QiN