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Mashup Score: 191Air pollution exposure and cardiometabolic risk - 3 hour(s) ago
The Global Burden of Disease assessment estimates that 20% of global type 2 diabetes cases are related to chronic exposure to particulate matter (PM) with a diameter of 2·5 μm or less (PM2·5). With 99% of the global population residing in areas where air pollution levels are above current WHO air quality guidelines, and increasing concern in regard to the common drivers of air pollution and climate change, there is a compelling need to understand the connection between air pollution and cardiometabolic disease, and pathways to address this preventable risk factor.
Source: www.thelancet.comCategories: General Medicine News, General HCPsTweet
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Mashup Score: 69
In this prespecified pooled analysis of the STEP-HFpEF and STEP-HFpEF DM trials, semaglutide was superior to placebo in improving heart failure-related symptoms and physical limitations, and reducing bodyweight in participants with obesity-related heart failure with preserved ejection fraction. These effects were largely consistent across patient demographic and clinical characteristics. Semaglutide was well tolerated.
Source: www.thelancet.comCategories: General Medicine News, General HCPsTweet
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Mashup Score: 69Moderna stalls on African vaccine manufacturing plans - 8 hour(s) ago
Moderna’s decision has been criticised by the Africa CDC, with experts urging countries to invest domestically. Paul Adepoju reports.
Source: www.thelancet.comCategories: General Medicine News, General HCPsTweet-
"Moderna is abandoning a commitment to build highly needed and relevant vaccine manufacturing capabilities in Africa" The Africa CDC has criticised Moderna's decision to pause plans for an mRNA vaccine manufacturing plant in Kenya. @pauladepoju reports. https://t.co/ESRmCDIRuS https://t.co/XeRbyp1ne4
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Mashup Score: 27Assisted dying needs a thoughtful and engaged dialogue - 1 day(s) ago
“It’s simple and humane”. Such was Emmanuel Macron’s explanation of the title of France’s new Aid in Dying bill, which aims to make it legal for adults with terminal illness to take lethal medication prescribed by a doctor. The wish to respect patient choice and alleviate suffering when all other options are exhausted is understandable, but the suggestion that anything related to assisted dying is simple is sorely misplaced.
Source: www.thelancet.comCategories: General Medicine News, General HCPsTweet
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Mashup Score: 558Randomised controlled trials evaluating artificial intelligence in clinical practice: a scoping review - 1 day(s) ago
This scoping review of randomised controlled trials on artificial intelligence (AI) in clinical practice reveals an expanding interest in AI across clinical specialties and locations. The USA and China are leading in the number of trials, with a focus on deep learning systems for medical imaging, particularly in gastroenterology and radiology. A majority of trials (70 [81%] of 86) report positive primary endpoints, primarily related to diagnostic yield or performance; however, the predominance of single-centre trials, little demographic reporting, and varying reports of operational efficiency raise concerns about the generalisability and practicality of these results.
Source: www.thelancet.comCategories: General Medicine News, General HCPsTweet
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Mashup Score: 558Randomised controlled trials evaluating artificial intelligence in clinical practice: a scoping review - 1 day(s) ago
This scoping review of randomised controlled trials on artificial intelligence (AI) in clinical practice reveals an expanding interest in AI across clinical specialties and locations. The USA and China are leading in the number of trials, with a focus on deep learning systems for medical imaging, particularly in gastroenterology and radiology. A majority of trials (70 [81%] of 86) report positive primary endpoints, primarily related to diagnostic yield or performance; however, the predominance of single-centre trials, little demographic reporting, and varying reports of operational efficiency raise concerns about the generalisability and practicality of these results.
Source: www.thelancet.comCategories: General Medicine News, General HCPsTweet
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Mashup Score: 25Youth engagement at The Lancet Child & Adolescent Health - 2 day(s) ago
In 2021, we made a commitment to expand our youth engagement at The Lancet Child & Adolescent Health and launched our inaugural Youth Advisory Panel, with eight youth advisors aged 16–24 years from diverse backgrounds globally. The Youth Advisory Panel sits alongside our International Advisory Board and has been influential in the journal’s work in the past 3 years. The editorial team has valued their thoughtful feedback on content and suggestions for topics, and enjoyed discussing issues such as gender equity, climate change, a career in research, and the impact of the COVID-19 pandemic on youth with them in podcasts and webinars, among many other projects.
Source: www.thelancet.comCategories: General Medicine News, General HCPsTweet
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Mashup Score: 558Randomised controlled trials evaluating artificial intelligence in clinical practice: a scoping review - 2 day(s) ago
This scoping review of randomised controlled trials on artificial intelligence (AI) in clinical practice reveals an expanding interest in AI across clinical specialties and locations. The USA and China are leading in the number of trials, with a focus on deep learning systems for medical imaging, particularly in gastroenterology and radiology. A majority of trials (70 [81%] of 86) report positive primary endpoints, primarily related to diagnostic yield or performance; however, the predominance of single-centre trials, little demographic reporting, and varying reports of operational efficiency raise concerns about the generalisability and practicality of these results.
Source: www.thelancet.comCategories: General Medicine News, General HCPsTweet
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Mashup Score: 74Reframing sepsis immunobiology for translation: towards informative subtyping and targeted immunomodulatory therapies - 2 day(s) ago
Sepsis is a common and deadly condition. Within the current model of sepsis immunobiology, the framing of dysregulated host immune responses into proinflammatory and immunosuppressive responses for the testing of novel treatments has not resulted in successful immunomodulatory therapies. Thus, the recent focus has been to parse observable heterogeneity into subtypes of sepsis to enable personalised immunomodulation. In this Personal View, we highlight that many fundamental immunological concepts such as resistance, disease tolerance, resilience, resolution, and repair are not incorporated into the current sepsis immunobiology model.
Source: www.thelancet.comCategories: General Medicine News, General Journals & SocietTweet
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Mashup Score: 539Randomised controlled trials evaluating artificial intelligence in clinical practice: a scoping review - 2 day(s) ago
This scoping review of randomised controlled trials on artificial intelligence (AI) in clinical practice reveals an expanding interest in AI across clinical specialties and locations. The USA and China are leading in the number of trials, with a focus on deep learning systems for medical imaging, particularly in gastroenterology and radiology. A majority of trials (70 [81%] of 86) report positive primary endpoints, primarily related to diagnostic yield or performance; however, the predominance of single-centre trials, little demographic reporting, and varying reports of operational efficiency raise concerns about the generalisability and practicality of these results.
Source: www.thelancet.comCategories: General Medicine News, General HCPsTweet
Air pollution is responsible for over 9 million annual deaths globally, with many attributed to cardiovascular causes. In @TheLancetEndo, authors provide mitigation strategies to control air pollution-related cardiometabolic disease: https://t.co/Pd8uBoqQ3i https://t.co/iYdrX498ov