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Mashup Score: 2
Aberrant G-protein coupled receptor (GPCR) expression is highly prevalent in cortisol-secreting primary bilateral macronodular adrenal hyperplasia (PBMAH) and unilateral adenomas. The aberrant expression of diverse GPCRs and their ligands play an important role in the over-function of various endocrine tumours. Examples include aberrant expression of MC2R, 5-HT4R, AVPR1A, LHCGR, and GnRHR in primary aldosteronism; GCGR, LHCGR, and 5-HT4R in phaeochromocytomas and paragangliomas; TRHR, GnRHR, GIPR, and GRP101 in pituitary somatotroph tumours; AVPR2, D2DR, and SSTR5 in pituitary corticotroph tumours; GLP1R, GIPR, and somatostatin receptors in medullary thyroid carcinoma; and SSTRs, GLP1R, and GIPR in other neuroendocrine tumours.
Source: www.thelancet.comCategories: General Medicine News, EndocrinologyTweet
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Mashup Score: 6Male hypogonadism: pathogenesis, diagnosis, and management - 2 day(s) ago
Organic male hypogonadism due to irreversible hypothalamic–pituitary–testicular (HPT) pathology is easily diagnosed and treated with testosterone-replacement therapy. However, controversy surrounds the global practice of prescribing testosterone to symptomatic men with low testosterone and non-gonadal factors reducing health status, such as obesity, type 2 diabetes, and ageing (ie, functional hypogonadism), but without identifiable HPT axis pathology. Health optimisation remains the gold-standard management strategy.
Source: www.thelancet.comCategories: General Medicine News, EndocrinologyTweet-
New—Male #hypogonadism: pathogenesis, diagnosis, and management https://t.co/k5ZVLagJu1 #MensHealth #testosterone https://t.co/tw6yrgD7bh
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Mashup Score: 1Protein-binding therapy: a new approach to lower cholesterol - 2 day(s) ago
Homozygous familial hypercholesterolaemia affects approximately 30 000 individuals worldwide.1,2 Patients have untreated high plasma LDL cholesterol over 10 mmol/L; physical signs include arcus cornealis, xanthelasmas, skin and tendon xanthomas, and markedly elevated risk of premature atherosclerotic cardiovascular disease and aortic valve disease.2 Inheritance is semi-dominant, meaning that parents who are heterozygous also have hypercholesterolaemia, albeit milder than their children with homozygous familial hypercholesterolaemia.
Source: www.thelancet.comCategories: General Medicine News, EndocrinologyTweet-
Linked Comment by Robert A Hegele: Protein-binding therapy: a new approach to lower cholesterol https://t.co/nXK6AjdQIw #familial hypercholesterolaemia #HoFH #LDL #cholesterol #lerodalcibep
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Mashup Score: 3
The LDL cholesterol response was highly variable, but generally similar in patients treated with both lerodalcibep and evolocumab. Importantly, the study showed the inability to predict response based on genotyping, reinforcing the rationale for PCSK9 inhibition in all patients with homozygous familial hypercholesterolemia and continuing its use in responders.
Source: www.thelancet.comCategories: General Medicine News, EndocrinologyTweet-
New—Lerodalcibep and evolocumab for the treatment of #homozygous #familial #hypercholesterolaemia with #PCSK9 inhibition (LIBerate-HoFH): a phase 3, randomised, open-label, crossover, non-inferiority trial https://t.co/Fxm5FRp6jb #HoFH #LDL #cholesterol #lerodalcibep
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Mashup Score: 2Is it time to revisit the recommendations for initiation of menopausal hormone therapy? - 2 day(s) ago
Findings from the Women’s Health Initiative studies led to menopausal hormone therapy (MHT) guidelines generally recommending the initiation of MHT be limited to women within 10 years of their menopause or before the age of 60 years. This recommendation has led to women who experience troublesome menopausal symptoms and who have not commenced MHT within these limits often being denied this type of therapy. Similarly, the majority of women who might benefit from the protective effects of MHT against bone loss and fracture are not offered this treatment option if they do not fit with these criteria.
Source: www.thelancet.comCategories: General Medicine News, EndocrinologyTweet-
New—Is it time to revisit the recommendations for initiation of menopausal hormone therapy? https://t.co/1sMS1HxVgW #menopause #MHT #HRT #WomensHealth https://t.co/4NLG5T11vy
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Mashup Score: 1A step towards more physiological glucocorticoid dosing in congenital adrenal hyperplasia - 3 day(s) ago
On Dec 12, 2024, the US Food and Drug Administration (FDA) approved crinecerfont for adults and paediatric patients with classic congenital adrenal hyperplasia.1
Source: www.thelancet.comCategories: General Medicine News, EndocrinologyTweet-
New—A step towards more physiological glucocorticoid dosing in congenital adrenal hyperplasia https://t.co/3UMc6MmxWZ #glucocorticoid #congenital #adrenal #hyperplasia
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Mashup Score: 5
Artificial intelligence (AI) use in diabetes care is increasingly being explored to personalise care for people with diabetes and adapt treatments for complex presentations. However, the rapid advancement of AI also introduces challenges such as potential biases, ethical considerations, and implementation challenges in ensuring that its deployment is equitable. Ensuring inclusive and ethical developments of AI technology can empower both health-care providers and people with diabetes in managing the condition.
Source: www.thelancet.comCategories: General Medicine News, EndocrinologyTweet-
Artificial intelligence for #diabetes care: current and future prospects https://t.co/KxoNQinoWb #AI #T2D #T1D #EASD2024
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Mashup Score: 2
After 45 years, I am retiring from the Italian National Health Service. If someone were to ask me what I think of the Italian National Health Service after all these years, I would consider Brenner’s theory on single nephron hyperfiltration injury.1 In chronic kidney disease, the progressive loss of functional nephrons—caused by conditions like hypertension and diabetes—forces the remaining nephrons to compensate through hyperfiltration and increased workload. This adaptive mechanism, mainly mediated by angiotensin II, temporarily sustains kidney function but ultimately accelerates damage.
Source: www.thelancet.comCategories: General Medicine News, EndocrinologyTweet-
New Correspondence: Angelo Avogaro reflects on: What does renal failure teach us about our National Health System? https://t.co/ieTVkTTqQs #FREE to read
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Mashup Score: 8
The rise and subsequent plateau in the incidence of thyroid cancer in the USA have been primarily driven by time period effects, likely due to changing patterns in diagnostic pressure. Variations in the incidence of thyroid cancer by age, which increased during the time frame of this study, seem to be driven predominantly by overdiagnosis. Although the incidence of thyroid cancer has plateaued, it remains at peak levels, suggesting that overdiagnosis remains a crucial unresolved public health issue.
Source: www.thelancet.comCategories: General Medicine News, EndocrinologyTweet-
New—Trends in #incidence, #metastasis, and #mortality from #thyroid #cancer in the #USA from 1975 to 2019: a population-based study of age, period, and cohort effects https://t.co/AD8PuM3xop #thyroidcancer
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Mashup Score: 0Promising treatment options with tirzepatide for Japanese individuals with obesity disease - 5 day(s) ago
Obesity is a common health problem affecting a considerable (and growing) proportion of adult populations worldwide.1 Although overweight and obesity are usually diagnosed by anthropometry, such as calculating indices representing increased body fat mass (eg, BMI), or, in particular, increased visceral fat mass (eg, waist circumference), the major threat is related to comorbidities associated with increasing degrees of obesity.2 Generally speaking, lifestyle interventions including intensive behavioural weight reduction programmes and previous generations of weight-loss medications have not prevented the number of people with obesity from rising between 2009 and 2022 worldwide, including in Japan.
Source: www.thelancet.comCategories: General Medicine News, EndocrinologyTweet-
Linked Comment by Michael A Nauck & Soo Lim: Promising treatment options with #tirzepatide for Japanese individuals with obesity disease https://t.co/zxbiaZDdsm #obesity
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New—Aberrant hormone receptors regulate a wide spectrum of endocrine tumors https://t.co/zTfrbepNtM #GPCRs https://t.co/CRcD9mctjM