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Mashup Score: 5How clinically relevant is statin-induced diabetes? - 15 hour(s) ago
Diabetes is a common chronic disease that affects up to 10% of adults worldwide.1 People with diabetes are at high risk for a wide variety of serious health consequences including, but not limited to, myocardial infarctions, strokes, heart failure, blindness, kidney failure, lower limb amputations, cognitive impairment, and many cancers. This increased risk is independent of other risk factors, is causally related to increased plasma glucose concentrations for cardiovascular events and some of the other consequences,2,3 and doubles the risk of all-cause death.
Source: www.thelancet.comCategories: General Medicine News, EndocrinologyTweet
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Mashup Score: 22Effect of population-wide screening for presymptomatic early-stage type 1 diabetes on paediatric clinical care - 19 hour(s) ago
Population-wide screening of children for presymptomatic early-stage type 1 diabetes is gaining momentum. Studies have demonstrated feasibility and acceptance, and shown that the rate of progression to clinical stage 3 diabetes is similar if islet autoantibody-positive early-stage type 1 diabetes is identified from general population or first-degree relative screening.1,2 Moreover, in conjunction with an education and follow-up package, screening significantly reduces the rates of ketoacidosis, symptoms, and hospitalisation.
Source: www.thelancet.comCategories: General Medicine News, EndocrinologyTweet
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Mashup Score: 5
Melatonin, a hormone primarily produced by the brain’s pineal gland, is typically secreted during darkness, aligning with the time when most people sleep. Melatonin plays a crucial part in signalling the onset of the biological night. It achieves this through multiple mechanisms, including inhibiting wake-promoting orexin neurons located in the hypothalamus, which serves as a central hub for regulating the sleep–wake cycle.1 The fact that melatonin can help to regulate sleep timing might also explain its popularity, particularly in countries where it is available over the counter.
Source: www.thelancet.comCategories: General Medicine News, EndocrinologyTweet
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Mashup Score: 36
With up to 23 years of follow-up of three large prospective cohorts of middle-aged and older men and women, self-reported melatonin supplement use was not associated with risk of type 2 diabetes or cardiovascular disease. Further research is warranted to assess if melatonin supplement use could mitigate the potential risks of type 2 diabetes and cardiovascular disease associated with rotating night shift work.
Source: www.thelancet.comCategories: General Medicine News, EndocrinologyTweet
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Mashup Score: 13
Launched as a public–private partnership funded by the Foundation for the National Institutes of Health, the Study to Advance Bone Mineral Density as a Regulatory Endpoint (SABRE) aims to change the framework for how clinical trials of new anti-osteoporosis drugs are conducted, to promote innovation in the field of osteoporosis, where underdiagnosis and undertreatment of disease have been deemed a crisis.1 Osteoporosis-related fractures, which lead to high morbidity and increased mortality, are a large and growing public health concern as one in two women and one in five men over the age of 50 years will have a fracture.
Source: www.thelancet.comCategories: General Medicine News, EndocrinologyTweet
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Mashup Score: 11Familial aggregation and heritability of childhood-onset and adult-onset type 1 diabetes: a Swedish register-based cohort study - 2 day(s) ago
Adult-onset type 1 diabetes seems to have weaker familial aggregation and lower heritability than childhood-onset type 1 diabetes. This finding suggests a larger contribution of environmental factors to the development of type 1 diabetes in adults than in children and highlights the need to identify and intervene on such factors.
Source: www.thelancet.comCategories: General Medicine News, EndocrinologyTweet
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Mashup Score: 22Effect of population-wide screening for presymptomatic early-stage type 1 diabetes on paediatric clinical care - 2 day(s) ago
Population-wide screening of children for presymptomatic early-stage type 1 diabetes is gaining momentum. Studies have demonstrated feasibility and acceptance, and shown that the rate of progression to clinical stage 3 diabetes is similar if islet autoantibody-positive early-stage type 1 diabetes is identified from general population or first-degree relative screening.1,2 Moreover, in conjunction with an education and follow-up package, screening significantly reduces the rates of ketoacidosis, symptoms, and hospitalisation.
Source: www.thelancet.comCategories: General Medicine News, EndocrinologyTweet
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Mashup Score: 42Air pollution exposure and cardiometabolic risk - 3 day(s) ago
The Global Burden of Disease assessment estimates that 20% of global type 2 diabetes cases are related to chronic exposure to particulate matter (PM) with a diameter of 2·5 μm or less (PM2·5). With 99% of the global population residing in areas where air pollution levels are above current WHO air quality guidelines, and increasing concern in regard to the common drivers of air pollution and climate change, there is a compelling need to understand the connection between air pollution and cardiometabolic disease, and pathways to address this preventable risk factor.
Source: www.thelancet.comCategories: General Medicine News, EndocrinologyTweet
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Mashup Score: 36
With up to 23 years of follow-up of three large prospective cohorts of middle-aged and older men and women, self-reported melatonin supplement use was not associated with risk of type 2 diabetes or cardiovascular disease. Further research is warranted to assess if melatonin supplement use could mitigate the potential risks of type 2 diabetes and cardiovascular disease associated with rotating night shift work.
Source: www.thelancet.comCategories: General Medicine News, EndocrinologyTweet
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Mashup Score: 5
Melatonin, a hormone primarily produced by the brain’s pineal gland, is typically secreted during darkness, aligning with the time when most people sleep. Melatonin plays a crucial part in signalling the onset of the biological night. It achieves this through multiple mechanisms, including inhibiting wake-promoting orexin neurons located in the hypothalamus, which serves as a central hub for regulating the sleep–wake cycle.1 The fact that melatonin can help to regulate sleep timing might also explain its popularity, particularly in countries where it is available over the counter.
Source: www.thelancet.comCategories: General Medicine News, EndocrinologyTweet
Hertzel C Gerstein & Marie Pigeyre comment on: How clinically relevant is #statin-induced #diabetes? https://t.co/Jes657xSn9 #FREE to read with registration (also FREE)