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Mashup Score: 2
This study did not reach its prespecified endpoint for darolutamide activity in patients with triple-negative breast cancer selected on the basis of immunohistochemistry for AR. Further studies selecting patients based on RNA profiling might allow better identification of tumours sensitive to anti-androgens.
Source: www.thelancet.comCategories: General Medicine News, Oncologists1Tweet
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Mashup Score: 2
With extended follow-up, palbociclib plus exemestane with ovarian function suppression continued to show a significant benefit in progression-free survival compared with capecitabine in premenopausal patients with hormone receptor-positive, HER2-negative metastatic breast cancer who had been previously treated with tamoxifen; however, no improvement in overall survival was seen. Given the progression-free survival benefit, the upfront use of palbociclib plus endocrine therapy is the preferred option for premenopausal women, although a capecitabine-first strategy might be an alternative treatment strategy for maintaining overall survival in resource-limited settings.
Source: www.thelancet.comCategories: General Medicine News, Oncologists1Tweet
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Mashup Score: 2
Our findings suggest that ipilimumab plus nivolumab maintains efficacy to at least 7 years in patients with active asymptomatic brain metastasis. Upfront ipilimumab plus nivolumab should be the standard of care for patients with melanoma brain metastasis; a trial investigating the role of stereotactic surgery in this new paradigm is ongoing.
Source: www.thelancet.comCategories: General Medicine News, Oncologists1Tweet
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Mashup Score: 10Largest trial of AI in breast cancer screening launched - 7 day(s) ago
The UK’s National Health Service (NHS) has launched the world’s largest prospective trial of using artificial intelligence (AI) to assess routine mammogram screenings. Nearly 700 000 women who have booked routine screenings in the UK will be invited to participate from April, 2025.
Source: www.thelancet.comCategories: General Medicine News, Oncologists1Tweet
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Mashup Score: 6Call to prioritise access to essential cancer medicines in Latin America and the Caribbean - 7 day(s) ago
On Feb 3, 2025, the Pan American Health Organization (PAHO) issued a statement calling on countries in Latin America and the Caribbean to prioritise access to essential cancer medicines. The statement noted that there are more than 4 million new cases of cancer every year in the Americas and over 1·4 million deaths. Patients do not always get the treatment they need, however. PAHO gave the example of childhood cancer. Every year, around 30 000 people younger than 19 years of age are diagnosed with cancer in Latin America and the Caribbean.
Source: www.thelancet.comCategories: General Medicine News, Oncologists1Tweet
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Mashup Score: 50
The addition of [177Lu] Lu-PSMA-617 to enzalutamide was associated with improved survival and some aspects of HRQOL in patients with high-risk metastatic castration-resistant prostate cancer. Our findings warrant phase 3 evaluation of adaptive-dosed [177Lu] Lu-PSMA-617 in combination with androgen receptor pathway inhibitors in people with metastatic prostate cancer.
Source: www.thelancet.comCategories: General Medicine News, Onc News and JournalsTweet
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Mashup Score: 50
The addition of [177Lu] Lu-PSMA-617 to enzalutamide was associated with improved survival and some aspects of HRQOL in patients with high-risk metastatic castration-resistant prostate cancer. Our findings warrant phase 3 evaluation of adaptive-dosed [177Lu] Lu-PSMA-617 in combination with androgen receptor pathway inhibitors in people with metastatic prostate cancer.
Source: www.thelancet.comCategories: General Medicine News, Onc News and JournalsTweet
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Mashup Score: 1
A 58-year-old male patient presented to the dermatology clinic at West China Hospital of Sichuan University (Chengdu, Sichuan Province, China) in July, 2023, with vesicles, bullae, and erythematous papules distributed across his neck, trunk, and limbs (figure, A). These lesions had progressively developed over the course of 1 month, accompanied by the onset of fever within the past 4 days. Physical examination revealed scattered erythematous papules distributed on the neck, trunk, and limbs, with firm oedematous erythema on the neck and back.
Source: www.thelancet.comCategories: General Medicine News, Oncologists1Tweet
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Mashup Score: 41
Consistent with the initial analysis of 3-year disease-free survival, the extended 5-year overall survival analysis from the RESOLVE trial confirmed the survival advantage of perioperative-SOX and adjuvant-SOX compared with the standard adjuvant-CapOx regimen. The SOX regimen, given perioperatively or as an adjuvant treatment, emerges as a potential standard treatment modality for locally advanced gastric or gastro-oesophageal junction cancer management in Asian patients.
Source: www.thelancet.comCategories: General Medicine News, Oncologists1Tweet
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Mashup Score: 1ECHR condemns Italy's response to toxic waste crisis - 11 day(s) ago
In a landmark judgement, the European Court of Human Rights (ECHR) has ruled that Italy is not protecting the right to life of 2·9 million people living in the southern provinces of Caserta and Naples. The ruling relates to the illegal dumping, burial, and burning of millions of tonnes of waste, including toxic and carcinogenic material, stretching back to at least the early 1980s. The affected area, which is made up of 90 municipalities, has become known as the Terra dei Fuochi (Land of Fires).
Source: www.thelancet.comCategories: General Medicine News, Oncologists1Tweet
New Research: #Darolutamide or capecitabine in triple-negative, androgen receptor-positive, advanced #breastcancer (UCBG 3-06 START): a multicentre, non-comparative, randomised, phase 2 trial #TNBC https://t.co/j2LiHLucVW