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Mashup Score: 3Personalised gait retraining for medial compartment knee osteoarthritis: a randomised controlled trial - 2 day(s) ago
Personalised foot angle modifications improve pain, reduce knee loading, and might slow osteoarthritis progression, making them a promising non-surgical treatment option for some individuals with medial compartment knee osteoarthritis.
Source: www.thelancet.comCategories: General Medicine News, RheumatologyTweet
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Mashup Score: 4Expanding the rheumatology lens: should we embrace POTS and post-infectious syndromes? - 7 day(s) ago
Like many of my colleagues who care for patients with dysautonomia, chronic fatigue syndrome, and infection-associated chronic illness, I stumbled into this work seemingly by accident. As a rheumatology fellow, I was trained to ask sharp, targeted questions to diagnose rheumatic diseases. When patients did not fit a recognisable pattern—when their symptoms, laboratory results, and exam findings did not add up—I would explain, often unhelpfully, that they did not have a rheumatological illness, and send them on their way.
Source: www.thelancet.comCategories: General Medicine News, RheumatologyTweet
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Mashup Score: 17
Fatigue and exercise intolerance affect more than 90% of patients with systemic lupus erythematosus (SLE), often persisting despite inactive disease.1 The pathophysiology of the disease remains elusive, leading to substantial disruption in daily life.
Source: www.thelancet.comCategories: General Medicine News, RheumatologyTweet
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Mashup Score: 7Towards sustainable relief in chronic low back pain - 9 day(s) ago
Non-specific low back pain remains one of the leading global causes of disability, substantially diminishing productivity and quality of life among working-age adults. A subset of individuals develop chronic non-specific low back pain, characterised by persistent functional limitations.1 This group accounts for a disproportionate share of health-care resource use compared with people experiencing acute or subacute episodes.2 When symptoms persist for longer than 12 weeks, neurophysiological adaptations can alter pain processing pathways, leading to a shift in the pain profile from predominantly nociceptive or neuropathic to nociplastic.
Source: www.thelancet.comCategories: General Medicine News, RheumatologyTweet
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Mashup Score: 57
Treatment sessions of CFT produced sustained effects at 3 years for people with chronic disabling low back pain. These long-term effects are novel and provide the opportunity to markedly reduce the effect of chronic back pain if the intervention can be widely implemented. Implementation requires scaling up of clinician training to increase accessibility and replication studies in diverse health-care systems.
Source: www.thelancet.comCategories: General Medicine News, RheumatologyTweet
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Mashup Score: 8Group-based cycling and education for hip osteoarthritis - 14 day(s) ago
Cost-effective first-line treatment for hip osteoarthritis is crucial given its prevalence.1 Higher-quality clinical guidelines recommend exercise, education, and a weight-loss intervention when appropriate.2 However, room for improvement remains regarding the effect and implementation of this first-line treatment.
Source: www.thelancet.comCategories: General Medicine News, RheumatologyTweet
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Mashup Score: 25
The CHAIN intervention showed superior outcomes compared with usual physiotherapy care, and the feasibility of delivering a low-cost, community-based intervention within the NHS was shown. However, longer-term benefits and broader generalisability warrant further investigation.
Source: www.thelancet.comCategories: General Medicine News, RheumatologyTweet
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Mashup Score: 6
Treat-to-target tapering of TNF inhibitors remains effective and safe for the maintenance of low disease activity for up to 2 years in patients with psoriatic arthritis and axial spondyloarthritis. Future research should explore the challenges to implementation of tapering strategies in routine care in these patients.
Source: www.thelancet.comCategories: General Medicine News, RheumatologyTweet
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Mashup Score: 10EULAR 2025 - 22 day(s) ago
Hector Chinoy (University of Manchester, UK) presented phase 2 data from the phase 2/3 ALKIVIA study on the safety and efficacy of efgartigimod (an IgG1 antibody Fc fragment targeting the neonatal Fc receptor) in adults with idiopathic inflammatory myopathies. Patients with dermatomyositis, immune-mediated necrotising myositis, polymyositis, or antisynthetase syndrome were randomly assigned (1:1), stratified by myositis subtype and disease severity, to receive subcutaneous efgartigimod 1000 mg once per week or placebo, in addition to standard-of-care background therapy.
Source: www.thelancet.comCategories: General Medicine News, RheumatologyTweet
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Mashup Score: 58The Lancet Rheumatology Home Page - 24 day(s) ago
Explore clinical research, expert reviews, and comment and opinion from The Lancet Rheumatology. A voice for rheumatology specialists worldwide
Source: www.thelancet.comCategories: General Medicine News, RheumatologyTweet
NEW RESEARCH—Personalised gait retraining for medial compartment knee #osteoarthritis: a randomised controlled trial https://t.co/Rej8JQHvG7 @ScottUhlrich @UtahMech #ASB2025 #Biomechanics https://t.co/2RM9zi2P5V