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Mashup Score: 9Cardiovascular risk in young people with childhood onset systemic lupus erythematosus - 1 day(s) ago
Since 1940, epidemiologists, clinicians, and scientists promoted increased awareness of the crucial importance of promoting preventive strategies for minimising the risk of poor health later in life. This is particularly relevant to children and young people with chronic inflammatory diseases, including childhood-onset systemic lupus erythematosus (SLE), which are almost always associated with increased risk of comorbidity. A wealth of literature emphasises the contribution of chronic inflammation to the development of subclinical atherosclerosis, which drives the increased risk of cardiovascular disease, and many guidelines across specialties highlight the need for cardiovascular disease risk stratification and tailored management.
Source: www.thelancet.comCategories: General Medicine News, RheumatologyTweet
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Mashup Score: 53
Two conventional synthetic DMARD tapering strategies were associated with significantly lower rates of flare-free survival compared with stable conventional synthetic DMARD treatment, and the data do not support non-inferiority. However, drug-free remission was achiveable for a significant subgroup of patients. This trial provides information on risk and benefits of different treatment strategies important for shared decision making.
Source: www.thelancet.comCategories: General Medicine News, RheumatologyTweet
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Mashup Score: 7
Little is known about the natural course and long-term outcomes of childhood-onset Sjögren’s disease due to its low prevalence, difference in clinical presentation between children and adults, and paucity of good quality research in paediatric populations. Delays in recognition of childhood-onset Sjögren’s disease are potentially explained by the heterogeneity of clinical manifestations at disease onset1–3 and the poor performance of adult classification criteria in children.4,5 Increased awareness in health professionals and involvement of multi-specialties are needed to improve disease recognition.
Source: www.thelancet.comCategories: General Medicine News, RheumatologyTweet
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Mashup Score: 5The Florida Scoring System for stratifying children with suspected Sjögren's disease: a cross-sectional machine learning study - 3 day(s) ago
The Florida Scoring System is a paediatrician-friendly tool that can be used to assist classification and long-term monitoring of suspected childhood Sjögren’s disease. The resulting stratification has important implications for clinical management, trial design, and pathobiological research. We found a highly symptomatic patient group with negative serology and diagnostic profiles, which warrants clinical attention. We further revealed that salivary gland ultrasonography can be a non-invasive alternative to minor salivary gland biopsy in children.
Source: www.thelancet.comCategories: General Medicine News, RheumatologyTweet
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Mashup Score: 29Debashish Danda - 4 day(s) ago
Debashish Danda, professor of rheumatology and immunology at Narayana Health Institute, Bengaluru, India, died on Feb 23, 2024. He had an illustrious career as a distinguished physician, teacher, and researcher, and his death is a heart-rending loss for the rheumatology community worldwide.
Source: www.thelancet.comCategories: General Medicine News, RheumatologyTweet
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Mashup Score: 29Debashish Danda - 4 day(s) ago
Debashish Danda, professor of rheumatology and immunology at Narayana Health Institute, Bengaluru, India, died on Feb 23, 2024. He had an illustrious career as a distinguished physician, teacher, and researcher, and his death is a heart-rending loss for the rheumatology community worldwide.
Source: www.thelancet.comCategories: General Medicine News, RheumatologyTweet
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Mashup Score: 60The Lancet Rheumatology Home Page - 4 day(s) ago
Explore clinical research, expert reviews, and comment and opinion from The Lancet Rheumatology. A voice for rheumatology specialists worldwide
Source: www.thelancet.comCategories: General Medicine News, RheumatologyTweet
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Mashup Score: 10
Participants adhered well to the non-operative interventions and their health-related quality of life improved. Participant and health professional feedback were extremely positive. These findings support progression to a full-scale effectiveness trial.
Source: www.thelancet.comCategories: General Medicine News, RheumatologyTweet
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Mashup Score: 2
In patients where antidrug antibodies were detected, remission was less likely to be reached and sustained, and infusion reaction or discontinuation of infliximab was more likely. Timely detection of antidrug antibodies by proactive therapeutic drug monitoring facilitated treatment decisions that reduced the negative consequences, both regarding infliximab effectiveness and safety. This highlights the role of proactive therapeutic drug monitoring in optimising infliximab therapy.
Source: www.thelancet.comCategories: General Medicine News, RheumatologyTweet
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Mashup Score: 16CAR T-cell therapy for SLE in children - 9 day(s) ago
On March 11, 2024, Seattle Children’s Hospital (Seattle, WA, USA) announced that it had received approval from the US Food and Drug Administration for a clinical trial of chimeric antigen receptor (CAR) T cells in children with systemic lupus erythematosus (SLE). The study will involve 12 individuals younger than 18 years with refractory SLE. They will each be given a single infusion of CAR T cells. The principal investigator is Shaun Jackson, Attending Physician at Seattle Children’s Nephrology and Rheumatology Program and Associate Professor of Paediatrics at the University of Washington (Seattle, WA, USA).
Source: www.thelancet.comCategories: General Medicine News, RheumatologyTweet
NEW COMMENT in our May issue—Coziana Ciurtin and colleagues discuss #cardiovascular risk in young people with childhood onset systemic #lupus erythematosus https://t.co/CCHjjKd0j4 @LauraLewMad11 @working1371 @carrainc @Jury_Lab @GeorgeARobinson