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Mashup Score: 61
Cells carrying a monoallelic germline BRCA2 mutation can bypass Knudson’s “two-hit” requirement to initiate tumorigenesis when the glycolytic metabolite methylglyoxal transiently disables BRCA2 function. Metabolic bypass of tumor suppressor activity may link metabolic reprogramming, metabolic disorders, or diet to early steps in carcinogenesis.
Source: www.cell.comCategories: General Medicine News, General HCPsTweet
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Mashup Score: 111Time-series reconstruction of the molecular architecture of human centriole assembly - 6 hour(s) ago
Expansion microscopy and time-series reconstructions enable elaboration of dynamic centriole assembly.
Source: www.cell.comCategories: General Medicine News, General HCPsTweet
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Mashup Score: 160A pan-cancer analysis of the microbiome in metastatic cancer - 19 hour(s) ago
Characterization of microbiome genomes at the species level in over 4,000 metastatic tumor biopsies identifies the distribution and diversity features of tumor-resident bacterial DNA at a pan-cancer scale, highlighting the associations between microbial community dynamics and tumor immunity and immunotherapy efficacy.
Source: www.cell.comCategories: General Medicine News, General Journals & SocietTweet
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Mashup Score: 57A genome-wide spectrum of tandem repeat expansions in 338,963 humans - 22 hour(s) ago
The Tandem Repeat Genome Aggregation Database (TR-gnomAD) is a biobank-scale reference of 0.86 million TRs derived from 338,963 whole-genome sequencing (WGS) samples of diverse ancestries.
Source: www.cell.comCategories: General Medicine News, General HCPsTweet
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Mashup Score: 61Cancer SLC6A6-mediated taurine uptake transactivates immune checkpoint genes and induces exhaustion in CD8+ T cells - 1 day(s) ago
Through SLC6A6-mediated taurine uptake, cancer cells become more aggressive and induce CD8+ T cell exhaustion by increasing ER stress and ATF4 transcription, resulting in immune evasion and tumor progression.
Source: www.cell.comCategories: General Medicine News, General Journals & SocietTweet
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Mashup Score: 57The SPATA5-SPATA5L1 ATPase complex directs replisome proteostasis to ensure genome integrity - 1 day(s) ago
The 55LCC heterohexameric ATPase complex promotes replisome proteostasis to maintain replication fork progression and genome stability.
Source: www.cell.comCategories: General Medicine News, General HCPsTweet
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Mashup Score: 97Short-distance vesicle transport via phase separation - 2 day(s) ago
Using the reconstituted presynaptic terminal local vesicle transport as a paradigm, Qiu and Wu et al. demonstrate that short-distance and directional vesicle transport can be achieved via regulated phase separation of vesicles with different protein condensates without involving molecular motors.
Source: www.cell.comCategories: General Medicine News, General HCPsTweet
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Mashup Score: 29
The flexible scaffold-based cheminformatics approach (FSCA) unlocks the potential of drug design to create polypharmacological drugs that open up treatment possibilities for complex brain disorders.
Source: www.cell.comCategories: General Medicine News, General HCPsTweet
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Mashup Score: 1153D reconstruction of a gastrulating human embryo - 2 day(s) ago
A 3D model of an intact Carnegie stage 8 human embryo is constructed from spatial transcriptomics profiling of serial transverse sections.
Source: www.cell.comCategories: General Medicine News, General HCPsTweet
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Mashup Score: 99
IGSF8, aberrantly expressed on malignant cells, functions as an innate immune checkpoint that inhibits cytotoxicity of natural killer cells. A monoclonal antibody targeting IGSF8 alone, or in combination with immune checkpoint blockade, shows therapeutic potential in preclinical models.
Source: www.cell.comCategories: General Medicine News, General HCPsTweet
Now online! A glycolytic metabolite bypasses “two-hit” tumor suppression by BRCA2 https://t.co/f1pUaNgEMH