For microbiome research to be translated into clinical applications, the field needs to move beyond correlational studies; we suggest adopting a multi-phase iterative approach that leverages in vivo and ex vivo strategies, as well as a combination of traditional microbiology, with big-data approaches.

Recordings from electrocorticography brain-computer interface (BCI) in tetraplegic participants find mesoscale representational stability and plasticity with neurofeedback that allows for long-term neuroprosthetic control of a robotic arm and hand.

Genomic analysis of the amphipod Hirondellea gigas revealed population homogeneity within the Mariana Trench but genetic differentiation between nearby hadal features. Multi-omics analysis showed that host-symbiotic interactions contribute to its adaptation to high-pressure and food-limited hadal environments.

Combining affinity purification with precision mass spectrometry and AI-driven molecular docking defines the network of endogenous protein-metabolite interactions in Escherichia coli.

Cryo-EM structures provide a snapshot of subunit assembly and atomic architecture in endogenous NMDA receptors, shedding light on their in vivo function, which is highly associated with learning and memory.

High-throughput experimental validation of genetic variants linked to eight psychiatric disorders reveals the regulatory mechanisms underlying variants with pleiotropic and disorder-specific effects.

Parturition timing in mice is controlled by locus-specific adjustment of histone H3 trimethyl lysine 27 (H3K27me3) levels within uterine fibroblasts in early gestation, with subsequent locus-specific H3K27me3 erosion associated with gene induction post-midgestation.