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Mashup Score: 10Five decades of genetics and genomics - 1 day(s) ago
Some of the most significant discoveries in the life sciences over the last 50 years stem from genetics and genomics. This field has also seen large-scale collaborative efforts yield fundamental milestones and results, such as the Human Genome Project. Despite a long road ahead, progress in both basic and clinical genetics now drives sweeping efforts to cure complex human ailments such as blood and psychiatric disorders, metabolic diseases, cancer, and neurodegeneration. While these large tent-pole endeavors receive the most attention, cutting-edge modern genetics techniques are foundational to the science that happens daily across the biomedical life sciences.
Source: www.cell.comCategories: General Medicine News, General HCPsTweet
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Mashup Score: 146Circadian tumor infiltration and function of CD8+ T cells dictate immunotherapy efficacy - 2 day(s) ago
Efficacy of CAR T cell therapy and immune checkpoint blockade in cancer can be improved by adjusting the time of treatment during the day due to rhythmic infiltration and function of T cells regulated by the circadian clock in T cells and endothelial cells in the tumor microenvironment.
Source: www.cell.comCategories: General Medicine News, General HCPsTweet
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Mashup Score: 15Deep mutational scanning of hepatitis B virus reveals a mechanism for cis-preferential reverse transcription - 2 day(s) ago
Deep mutational scanning reveals that conserved proline codons at the 3′ end of the hepatitis B virus polymerase open reading frame stall ribosomes. As a result, the ribosome physically tethers the nascent polymerase to its encoding RNA, which enforces cis-preferential genome RNA packaging and reverse transcription.
Source: www.cell.comCategories: General Medicine News, General HCPsTweet
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Mashup Score: 159Mapping the cellular biogeography of human bone marrow niches using single-cell transcriptomics and proteomic imaging - 4 day(s) ago
This study employs scRNA-seq and CODEX multiplexed imaging to elucidate the cellular and spatial architecture of the human bone marrow microenvironment. Rare non-hematopoietic cells are enriched and profiled. Cellular neighborhoods and cell-cell interactions are revealed through integrative analysis of the multiomics data.
Source: www.cell.comCategories: General Medicine News, General HCPsTweet
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Mashup Score: 11Creating connections when we talk about science - 7 day(s) ago
For Cell’s 50th anniversary Focus on Immunology, scientific editor Cheri Sirois asked science communicator Liz Neeley, founding partner of Liminal and cofounder of Solving for Science, to discuss strategies for tackling technical complexity and for engaging effectively with broad audiences. A lightly edited transcript of their conversation is shared here.
Source: www.cell.comCategories: General Medicine News, General HCPsTweet
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Mashup Score: 42FLT3L governs the development of partially overlapping hematopoietic lineages in humans and mice - 8 day(s) ago
Adult humans with inherited, complete FLT3L deficiency enable valuable insights into the role of the hematopoietic growth factor FLT3L in human hematopoiesis, revealing that FLT3L deficiencies impair monocyte, dendritic, and B cell development but not NK cell development. This study reveals key differences in the role of FLT3L in humans versus mice.
Source: www.cell.comCategories: General Medicine News, General HCPsTweet
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Mashup Score: 73Small-molecule-induced epigenetic rejuvenation promotes SREBP condensation and overcomes barriers to CNS myelin regeneration - 8 day(s) ago
Oligodendrocytes in multiple sclerosis lesions exhibit epigenetic silencing that precludes myelin restoration. This study identifies a small-molecule inhibitor that counteracts epigenetic silencing, effectively enhancing myelin production and thereby promoting (re)myelination in animal models and human organoids while reversing age-related cognitive decline.
Source: www.cell.comCategories: General Medicine News, General HCPsTweet
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Mashup Score: 3A transcription factor atlas of directed differentiation - 8 day(s) ago
(Cell 186, 209–229.e1–e26; January 5, 2023)
Source: www.cell.comCategories: General Medicine News, General HCPsTweet
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Mashup Score: 179
Systemically administered mRNA aggregates (RNA-LPA) transfect lymphoreticular organs, inducing a massive cytokine/chemokine response that rapidly reprograms the tumor microenvironment while mobilizing dendritic cells/lymphocytes to elicit rapid and enduring cancer immunotherapy.
Source: www.cell.comCategories: General Medicine News, General HCPsTweet
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Mashup Score: 3Home – Hallmarks of Cancer - 9 day(s) ago
Hallmarks of Cancer
Source: www.cell-symposia.comCategories: General Medicine News, General Journals & SocietTweet
In last week's anniversary focus issue on #Genetics & #Genomics, the Cell team reflected on the impact that genetics research has had on the journal since its launch 50 years ago. To hear more, read the editorial: https://t.co/2HUxmDH4WM #50YearsofCell https://t.co/GIx7yuQ2Vo