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Mashup Score: 6
Leveraging the transformative potential of thalidomide derivatives, Wang et al. unveil BCL-2 protein degraders. Through proteomics and AlphaFold modeling, this work identifies key interactions enabling the targeting of venetoclax-resistant mutations, offering new therapeutic avenues and enhanced survival prospects in cancer models.
Source: www.cell.comCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 143Clinical drug screening reveals clofazimine potentiates the efficacy while reducing the toxicity of anti-PD-1 and CTLA-4 immunotherapy - 9 hour(s) ago
Attempts to improve dual anti-PD-1+CTLA-4 ICB efficacy by including additional therapeutics have been largely discouraged due to concerns of further increasing toxicity. Xue et al. identify that the antibiotic clofazimine potentiates the antitumor effects of anti-PD-1+CTLA-4 immunotherapy and mitigates immune-related adverse effects in mice.
Source: www.cell.comCategories: General Medicine News, Onc News and JournalsTweet
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Mashup Score: 18Vertebrate centromeres in mitosis are functionally bipartite structures stabilized by cohesin - 10 hour(s) ago
Sacristan, Samejima et al. report that centromeric chromatin rearranges into a bipartite structure during mitosis, defining two microtubule-binding subdomains on the kinetochore. The engagement of subdomains from single kinetochores to opposite spindle poles is a common configuration of merotelic attachments and a source of chromosomal instability in cancer cells.
Source: www.cell.comCategories: General Medicine News, General HCPsTweet
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Mashup Score: 18Palmitoyl transferase ZDHHC20 promotes pancreatic cancer metastasis - 10 hour(s) ago
Tomić et al. uncover regulators of PDAC metastasis and validate the pivotal role of ZDHHC20. Despite no impact on in vitro cell phenotype and primary tumor growth, ZDHHC20 depletion curbs metastasis in mice. This effect is dependent on the immune system, particularly natural killer cells.
Source: www.cell.comCategories: General Medicine News, General HCPsTweet
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Mashup Score: 10Aging-induced tRNAGlu-derived fragment impairs glutamate biosynthesis by targeting mitochondrial translation-dependent cristae organization - 11 hour(s) ago
Li et al. demonstrate that aging induces dephosphorylation of angiogenin, leading to its mislocalization in the cytoplasm to cleave tRNAGlu. Mitochondrial accumulation of the cleavage product Glu-5′tsRNA-CTC impairs mitochondrial translation, cristae organization, and glutaminase-dependent glutamate biogenesis. Thus, Glu-5′tsRNA-CTC accelerates brain aging and ASO targeting Glu-5′tsRNA-CTC rescues age-related phenotypes in mice.
Source: www.cell.comCategories: General Medicine News, NeurologyTweet
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Mashup Score: 72Tuft cell acetylcholine is released into the gut lumen to promote anti-helminth immunity - 12 hour(s) ago
Intestinal tuft cells are known as sentinels capable of initiating type 2 immune responses upon parasite infections. Ndjim et al. now report a direct effector function for intestinal tuft cells during such immune responses by increasing their acetylcholine biosynthesis and releasing it into the gut lumen. Helminth fecundity is directly inhibited by acetylcholine, acting through worm muscarinic receptors.
Source: www.cell.comCategories: General Medicine News, Allergy-ImmunologyTweet
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Mashup Score: 35The adipose-neural axis is involved in epicardial adipose tissue-related cardiac arrhythmias - 12 hour(s) ago
Fan et al. establish a stem cell-based coculture model to mimic the in vivo cardiac microenvironment and elucidate that the adipose-neural interaction plays a critical role in epicardial adipose tissue-related cardiac arrhythmia through leptin-NPY axis. Their results may provide potential therapeutic targets for treating arrhythmia.
Source: www.cell.comCategories: General Medicine News, Expert PicksTweet
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Mashup Score: 44The histone lysine methyltransferase MLL1 regulates the activation and functional specialization of regulatory T cells - 13 hour(s) ago
Wang et al. explore the functional role of MLL1 in mouse Tregs. They demonstrate that MLL1 is not required for the thymic development of Tregs but plays a vital role in immune self-tolerance by creating an appropriate epigenetic context for Treg activation and functional specialization.
Source: www.cell.comCategories: General Medicine News, General Journals & SocietTweet
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Mashup Score: 18Spinal projecting neurons in rostral ventromedial medulla co-regulate motor and sympathetic tone - 14 hour(s) ago
The spinal projecting neurons in the rostral ventromedial medulla co-innervate sympathetic preganglionic neurons and motor-related regions in the spinal cord. The excitatory and inhibitory populations in this same brainstem region have opposite functions in regulating somatic and sympathetic tone in different arousal states.
Source: www.cell.comCategories: General Medicine News, General HCPsTweet
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Mashup Score: 27The RIPK1 death domain restrains ZBP1- and TRIF-mediated cell death and inflammation - 14 hour(s) ago
RIPK1 regulates cell death via kinase-dependent and kinase-independent mechanisms. Utilizing mice expressing RIPK1 with a point mutation disrupting its death domain, Imai et al. show that RIPK1 death domain interactions are critical to suppress ZBP1- and TRIF-induced activation of RIPK3 and necroptosis.
Source: www.cell.comCategories: General Medicine News, Allergy-ImmunologyTweet
Thalidomide derivatives degrade BCL-2 by reprogramming the binding surface of CRBN https://t.co/KzyePNnQkc