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Mashup Score: 35CD80 on skin stem cells promotes local expansion of regulatory T cells upon injury to orchestrate repair within an inflammatory environment - 17 hour(s) ago
In skin injury, the inflammatory environment can impact repair mediated by skin stem cells. Luan, Truong, Vuchkovska, et al. show that hair follicle stem cells migrate into the wound, activate immune-modulatory molecules, and expand extrathymic regulatory T cells to facilitate the resolution of neutrophil responses and the initiation of wound repair.
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Mashup Score: 58Transcription factor Tox2 is required for metabolic adaptation and tissue residency of ILC3 in the gut - 20 hour(s) ago
Group 3 innate lymphoid cells (ILC3) play critical roles in gut homeostasis. Das et al. show that transcription factor Tox2 is required by ILC3 to metabolically adapt to the gut environment. They identify interleukin (IL)-17 as an important signal that induces Tox2 expression in gut ILC3, but not in other immune cells.
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Mashup Score: 85Eliciting a single amino acid change by vaccination generates antibody protection against group 1 and group 2 influenza A viruses - 2 day(s) ago
Differences in glycosylation prevent antibodies from widely engaging the otherwise conserved hemagglutinin (HA) stem of influenza A viruses (IAVs). Ray et al. deploy a humanized mouse to elicit a broadly neutralizing antibody (bnAb) response that results in group 1 and group 2 IAV protection via a single amino acid mutation that tilts the immunoglobulin to accommodate glycan diversity.
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Mashup Score: 15625-Hydroxycholesterol regulates lysosome AMP kinase activation and metabolic reprogramming to educate immunosuppressive macrophages - 9 day(s) ago
Cholesterol increases macrophage-mediated inflammation, but how oxysterols control tumor-associated macrophages (TAMs) remains unclear. Xiao et al. show that TAMs exhibit elevated expression of CH25H, resulting in lysosome-accumulated 25HC that activates AMPKα to promote STAT6-dependent ARG1 production. CH25H-deficient macrophages switch “cold tumors” into “hot tumors” and improve anti-PD-1-mediated anti-tumor efficacy.
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Mashup Score: 1
Signaling via Notch receptors intrinsically regulates tumor cells, promoting tumor progression. Mandula et al. examine the impact of Notch ligands on cancer cells on anti-tumor immunity in lung cancer and find that deletion of Jagged2 promotes expansion of immunostimulatory macrophages and anti-tumor T cell immunity. Mechanistically, in the absence of Jagged2, the Notch ligand DLL1/4 on tumor cells rewires macrophages via Notch-mediated induction of the transcription factor IRF4.
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Mashup Score: 86Jagged2 targeting in lung cancer activates anti-tumor immunity via Notch-induced functional reprogramming of tumor-associated macrophages - 10 day(s) ago
Signaling via Notch receptors intrinsically regulates tumor cells, promoting tumor progression. Mandula et al. examine the impact of Notch ligands on cancer cells on anti-tumor immunity in lung cancer and find that deletion of Jagged2 promotes expansion of immunostimulatory macrophages and anti-tumor T cell immunity. Mechanistically, in the absence of Jagged2, the Notch ligand DLL1/4 on tumor cells rewires macrophages via Notch-mediated induction of the transcription factor IRF4.
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Mashup Score: 90Regulation of T helper cell differentiation by the interplay between histone modification and chromatin interaction - 13 day(s) ago
Cis-regulatory elements and trans-acting factors coordinate to regulate T helper cell differentiation. Liu et al. characterize the histone modification and chromatin interaction dynamics in this process. The H3K4me1 landscape established by MLL4 in naive CD4+ T cells is critical for rewiring the chromatin interaction network orchestrated by GATA3 during Th differentiation.
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Mashup Score: 109
Intraepithelial mast cells (IEMCs) were first observed 105 years ago, yet their functions remain enigmatic. Yang et al. reveal that IEMCs are required for epithelial gasdermin C activation and IEMC-epithelium crosstalk constitutes a critical step in type 2 immune responses.
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Mashup Score: 370
Recent studies revealed the existence of common principles of innate immune mechanisms across kingdoms and between the innate and adaptive branches of immunity in vertebrates. Lemaitre et al. discuss some key concepts of innate immunity that have renewed our vision of the immune system.
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Mashup Score: 238Control of adaptive immunity by pattern recognition receptors - 13 day(s) ago
Signals from the innate immune system initiate and guide adaptive immune responses. Barton and colleagues recount key discoveries leading to the current understanding of this communication and discuss how variation in the signals generated from pattern recognition receptors in dendritic cells or other cell types can influence T cell differentiation and the ensuing adaptive immune response.
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