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Mashup Score: 80Antigen-level resolution of commensal-specific B cell responses can be enabled by phage display screening coupled with B cell tetramers - 19 hour(s) ago
Adaptive immunity to commensal microbes promotes tissue homeostasis, immunity, and repair, but approaches to identify commensal-specific B cell responses are lacking. Verma et al. utilize phage display screening and subsequent generation of B cell tetramers to identify anatomical compartmentalization of SFB-specific B cell responses in gut-associated lymphoid tissues.
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Mashup Score: 122Glucose-driven histone lactylation promotes the immunosuppressive activity of monocyte-derived macrophages in glioblastoma - 6 day(s) ago
There are no effective approaches to overcome the immunosuppressive activity of tumor-associated macrophages (TAMs). De Leo et al. report that monocyte-derived macrophages (MDMs), but not microglia (MGs), are major contributors to the immunosuppression associated with TAMs in glioblastoma and demonstrate that PERK-perturbed glucose metabolism drives MDM immunosuppressive programs via histone lactylation. Targeting of PERK-driven histone lactylation boosts the effect of immunotherapy.
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Mashup Score: 55Lysosomal endonuclease RNase T2 and PLD exonucleases cooperatively generate RNA ligands for TLR7 activation - 7 day(s) ago
TLR7 is critical for recognizing RNA virus infection and initiating antiviral responses. Bérouti et al. demonstrate how RNase T2 and PLD exonucleases generate RNA fragments for TLR7 activation, thus providing insights into immune recognition of exogenous RNAs, with potential therapeutic implications.
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Mashup Score: 66Integrating population and single-cell variations in vaccine responses identifies a naturally adjuvanted human immune setpoint - 8 day(s) ago
Mulè et al. provide a framework for integrating human population and single-cell variations to study vaccine responses with and without the adjuvant AS03. They uncover AS03-specific B cell survival and innate-sensing signatures 1 day after vaccination. Furthermore, some AS03-induced response cell states are already present at baseline in
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Mashup Score: 38
Multilayered gene regulation orchestrates cell-type-specific cytokine expression. Liu et al. examine the impact of chromatin loop formation on the expression of IFN-γ and IL-22, which are cytokine loci closely located in the genome, and identify an inducible topologically associating domain required for proper IFN-γ production in Th1 cells. Deleting a CTCF-binding site within this domain leads to lineage-specific cytokine dysregulation and increased susceptibility to pathogens.
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Mashup Score: 48
Regulatory T (Treg) cells in epidydimal visceral adipose tissue (eVAT) regulate metabolic homeostasis. Wang et al. identify a distinct compartment of eVAT-Treg cells that rein in the differentiation of adipocytes from stromal progenitors via the molecular mediator oncostatin M, thereby promoting insulin sensitivity and metabolic health.
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Mashup Score: 81CD80 on skin stem cells promotes local expansion of regulatory T cells upon injury to orchestrate repair within an inflammatory environment - 13 day(s) ago
In skin injury, the inflammatory environment can impact repair mediated by skin stem cells. Luan, Truong, Vuchkovska, et al. show that hair follicle stem cells migrate into the wound, activate immune-modulatory molecules, and expand extrathymic regulatory T cells to facilitate the resolution of neutrophil responses and the initiation of wound repair.
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Mashup Score: 92Transcription factor Tox2 is required for metabolic adaptation and tissue residency of ILC3 in the gut - 13 day(s) ago
Group 3 innate lymphoid cells (ILC3) play critical roles in gut homeostasis. Das et al. show that transcription factor Tox2 is required by ILC3 to metabolically adapt to the gut environment. They identify interleukin (IL)-17 as an important signal that induces Tox2 expression in gut ILC3, but not in other immune cells.
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Mashup Score: 85Eliciting a single amino acid change by vaccination generates antibody protection against group 1 and group 2 influenza A viruses - 14 day(s) ago
Differences in glycosylation prevent antibodies from widely engaging the otherwise conserved hemagglutinin (HA) stem of influenza A viruses (IAVs). Ray et al. deploy a humanized mouse to elicit a broadly neutralizing antibody (bnAb) response that results in group 1 and group 2 IAV protection via a single amino acid mutation that tilts the immunoglobulin to accommodate glycan diversity.
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Mashup Score: 15625-Hydroxycholesterol regulates lysosome AMP kinase activation and metabolic reprogramming to educate immunosuppressive macrophages - 21 day(s) ago
Cholesterol increases macrophage-mediated inflammation, but how oxysterols control tumor-associated macrophages (TAMs) remains unclear. Xiao et al. show that TAMs exhibit elevated expression of CH25H, resulting in lysosome-accumulated 25HC that activates AMPKα to promote STAT6-dependent ARG1 production. CH25H-deficient macrophages switch “cold tumors” into “hot tumors” and improve anti-PD-1-mediated anti-tumor efficacy.
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