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Mashup Score: 1Jagged2 targeting in lung cancer activates anti-tumor immunity via Notch-induced functional reprogramming of tumor-associated macrophages - 21 day(s) ago
Signaling via Notch receptors intrinsically regulates tumor cells, promoting tumor progression. Mandula et al. examine the impact of Notch ligands on cancer cells on anti-tumor immunity in lung cancer and find that deletion of Jagged2 promotes expansion of immunostimulatory macrophages and anti-tumor T cell immunity. Mechanistically, in the absence of Jagged2, the Notch ligand DLL1/4 on tumor cells rewires macrophages via Notch-mediated induction of the transcription factor IRF4.
Source: www.cell.comCategories: General Medicine News, Allergy-ImmunologyTweet
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Mashup Score: 86Jagged2 targeting in lung cancer activates anti-tumor immunity via Notch-induced functional reprogramming of tumor-associated macrophages - 22 day(s) ago
Signaling via Notch receptors intrinsically regulates tumor cells, promoting tumor progression. Mandula et al. examine the impact of Notch ligands on cancer cells on anti-tumor immunity in lung cancer and find that deletion of Jagged2 promotes expansion of immunostimulatory macrophages and anti-tumor T cell immunity. Mechanistically, in the absence of Jagged2, the Notch ligand DLL1/4 on tumor cells rewires macrophages via Notch-mediated induction of the transcription factor IRF4.
Source: www.cell.comCategories: General Medicine News, Allergy-ImmunologyTweet
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Mashup Score: 90Regulation of T helper cell differentiation by the interplay between histone modification and chromatin interaction - 24 day(s) ago
Cis-regulatory elements and trans-acting factors coordinate to regulate T helper cell differentiation. Liu et al. characterize the histone modification and chromatin interaction dynamics in this process. The H3K4me1 landscape established by MLL4 in naive CD4+ T cells is critical for rewiring the chromatin interaction network orchestrated by GATA3 during Th differentiation.
Source: www.cell.comCategories: General Medicine News, Allergy-ImmunologyTweet
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Mashup Score: 109
Intraepithelial mast cells (IEMCs) were first observed 105 years ago, yet their functions remain enigmatic. Yang et al. reveal that IEMCs are required for epithelial gasdermin C activation and IEMC-epithelium crosstalk constitutes a critical step in type 2 immune responses.
Source: www.cell.comCategories: General Medicine News, Allergy-ImmunologyTweet
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Mashup Score: 370
Recent studies revealed the existence of common principles of innate immune mechanisms across kingdoms and between the innate and adaptive branches of immunity in vertebrates. Lemaitre et al. discuss some key concepts of innate immunity that have renewed our vision of the immune system.
Source: www.cell.comCategories: General Medicine News, Allergy-ImmunologyTweet
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Mashup Score: 238Control of adaptive immunity by pattern recognition receptors - 25 day(s) ago
Signals from the innate immune system initiate and guide adaptive immune responses. Barton and colleagues recount key discoveries leading to the current understanding of this communication and discuss how variation in the signals generated from pattern recognition receptors in dendritic cells or other cell types can influence T cell differentiation and the ensuing adaptive immune response.
Source: www.cell.comCategories: General Medicine News, Allergy-ImmunologyTweet
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Mashup Score: 238Control of adaptive immunity by pattern recognition receptors - 25 day(s) ago
Signals from the innate immune system initiate and guide adaptive immune responses. Barton and colleagues recount key discoveries leading to the current understanding of this communication and discuss how variation in the signals generated from pattern recognition receptors in dendritic cells or other cell types can influence T cell differentiation and the ensuing adaptive immune response.
Source: www.cell.comCategories: General Medicine News, Allergy-ImmunologyTweet
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Mashup Score: 175
TLRs play crucial roles in the innate immune system by recognizing pathogen-associated molecular patterns. Despite their protective roles, aberrations in TLRs contribute to inflammatory and autoimmune disorders. Akira et al. offer insights into TLR discovery, ligands, and signaling and their implications in diseases.
Source: www.cell.comCategories: General Medicine News, Allergy-ImmunologyTweet
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Mashup Score: 125Myeloid C-type lectin receptors in innate immune recognition - 26 day(s) ago
C-type lectin receptors (CLRs) comprise a vast family of proteins, several of which play key roles in the immune system. In this article, Reis e Sousa et al. review the biology of CLRs expressed by myeloid cells and their role in innate immune responses to infection, commensal organisms, and tissue injury or dysfunction.
Source: www.cell.comCategories: General Medicine News, Allergy-ImmunologyTweet
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Mashup Score: 214
The cGAS-STING pathway detects intracellular DNA and activates a potent antiviral response. Dvorkin and colleagues summarize recent insights into cGAS-STING biology and its role in host defense, immunopathologies, and anti-tumor immunity.
Source: www.cell.comCategories: General Medicine News, Allergy-ImmunologyTweet
RT @JAng_Vaz: Congratulations to all of you guys for this amazing effort and contribution. https://t.co/oCgNXx6xob