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Mashup Score: 0Loss of LPAR6 and CAB39L dysregulates the basal-to-luminal urothelial differentiation program, contributing to bladder carcinogenesis - 2 day(s) ago
Lee et al. report that FR genes mapping near RB1 are associated with the development of field effects initiating bladder carcinogenesis. Two of these genes are distinctively downregulated in luminal and basal cancers. Their loss contributes to carcinogenesis by dysregulating urothelial differentiation mediated by cholesterol and the unfolded protein reaction.
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Mashup Score: 9Precision off-the-shelf natural killer cell therapies for oncology with logic-gated gene circuits - 2 day(s) ago
Treating acute myeloid leukemia with conventional, single-target CAR cell therapies is challenging due to tumor heterogeneity and because tumor antigens are found on hematopoietic stem cells. Frankel et al. design logic-gated CAR-natural killer cells that simultaneously detect three antigens on prospective target cells to safely decide whether to kill them.
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Mashup Score: 6Dominant role for pigment epithelial CRALBP in supplying visual chromophore to photoreceptors - 2 day(s) ago
Bassetto et al. report that CRALBP within the retinal pigment epithelium (RPE) plays a primary role in the regeneration of rod and cone visual pigments. Müller glia CRALBP supports cone function under extended light exposure conditions. Removing CRALBP from the RPE reproduces the ocular phenotypes observed in global CRALBP knockout mice.
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Mashup Score: 32Focal clusters of peri-synaptic matrix contribute to activity-dependent plasticity and memory in mice - 2 day(s) ago
Chelini et al. demonstrate that versican regulates the expression of a specific proteoglycan glycoform, contributing to long-term potentiation and hippocampal-dependent memory in mice. These findings bring attention to a potential mechanism contributing to the spatial arrangement of synaptic ensembles during the active phase of experience-dependent plasticity.
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Mashup Score: 0Home – Cell Symposia: Functional RNAs - 3 day(s) ago
Cell Symposia: Functional RNAs
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Mashup Score: 4Environmental purines decrease Pseudomonas aeruginosa biofilm formation by disrupting c-di-GMP metabolism - 3 day(s) ago
Kennelly et al. demonstrate that adenosine and inosine decrease c-di-GMP and biofilm formation of Pseudomonas aeruginosa. Without (p)ppGpp, xanthosine and guanosine increase c-di-GMP, but adenosine and inosine block this increase. This work reveals that environmental purines can act as a cue to shift bacteria away from the recalcitrant biofilm state.
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Mashup Score: 76The MYCN 5′ UTR as a therapeutic target in neuroblastoma - 4 day(s) ago
MYCN amplification is a key driver of high-risk neuroblastoma. Volegova et al. capitalize on the dependence of MYCN-amplified neuroblastoma cells on increased protein synthesis by using amidino-rocaglates to inhibit translation initiation factor eIF4A1, resulting in direct targeting of the MYCN mRNA and selective cytotoxicity in animal models.
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Mashup Score: 35The molecular basis of scale development highlighted by a single-cell atlas of Bicyclus anynana butterfly pupal forewings - 4 day(s) ago
Butterfly wing tissues are composed of various cell types including differently shaped and colored scales, sensory and glandular cells, and epidermal cells. Prakash et al. use single-cell sequencing to identify markers of different cell types and show that HR38 and senseless regulate scale cell differentiation.
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Mashup Score: 36Adipocyte PI3K links adipostasis with baseline insulin secretion at fasting through an adipoincretin effect - 4 day(s) ago
Increased blood glucose and glucoincretins induce insulin secretion in response to feeding. Becattini et al. show that baseline insulin secretion in fasting is under a feedback control governed by insulin-PI3K signaling within the adipocyte, linking insulin action in adipostasis with insulin secretion, a phenomenon that they named the adipoincretin effect.
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Mashup Score: 19Individual Atg8 paralogs and a bacterial metabolite sequentially promote hierarchical CASM-xenophagy induction and transition - 4 day(s) ago
Sakuma et al. show that GATE16 and GBRP play a pivotal role in CASM shedding and subsequent xenophagy induction, respectively, by establishing an autophagy matrix based on the relationship between Atg8 paralogs, autophagy adaptors, poly-ubiquitin, and Atg4 paralogs. Bacterial manipulation of CASM shedding and xenophagy induction via H2O2-Ca2+ axis is revealed.
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Loss of LPAR6 and CAB39L dysregulates the basal-to-luminal urothelial differentiation program, contributing to bladder carcinogenesis https://t.co/d8Ts0Nfr9s