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Mashup Score: 32Structural and mechanistic insights into the function of Leishmania ribosome lacking a single pseudouridine modification - 4 day(s) ago
Rajan et al. demonstrate the significance of a single rRNA modification for the structure and the function of ribosomes, thus affecting the translation of a subset of mRNAs. The changes in ribosome structure affect tRNA selectivity, resulting in codon bias.
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Mashup Score: 52Dopamine-sensitive neurons in the mesencephalic locomotor region control locomotion initiation, stop, and turns - 4 day(s) ago
Juárez Tello et al. show that dopamine-sensitive neurons in the mesencephalic locomotor region control movement. D1 receptor-positive neurons in the cuneiform and pedunculopontine nuclei promote locomotion. D2 receptor-positive neurons in the cuneiform nucleus stop locomotion, while D2 receptor-positive neurons in the pedunculopontine nucleus induce ipsilateral turning.
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Mashup Score: 72Astroglial gap junctions strengthen hippocampal network activity by sustaining afterhyperpolarization via KCNQ channels - 4 day(s) ago
Dossi et al. investigate the mechanisms underlying neuronal network activity modulation by gap-junction-mediated astroglial networks. Combining modeling and experimental approaches, they show that astroglial networks strengthen hippocampal bursting patterns by sustaining neuronal afterhyperpolarization via extracellular potassium modulation of KCNQ potassium channels. This pathway controls in vivo physiological oscillatory activity.
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Mashup Score: 19Identification of WNK1 as a therapeutic target to suppress IgH/MYC expression in multiple myeloma - 5 day(s) ago
Ye et al. report the identification and characterization of WNK1 as a regulator of MYC expression in multiple myeloma by modulating the IgH enhancer. Genetic and pharmacological inhibition of WNK1 reduces the expression of MYC and other IgH translocation partners, suppressing multiple myeloma cell growth in vitro and in vivo.
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Mashup Score: 25
Yang et al. structurally characterize antibody responses to H2N2 vaccination in H2-naive and H2-exposed people, demonstrating temporal immune biases to conserved and variable regions on HA. H2N2 vaccination elicited antibodies to conserved sites on the HA stem, receptor-binding site, and medial junction.
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Mashup Score: 55Circadian-clock-controlled endocrine and cytokine signals regulate multipotential innate lymphoid cell progenitors in the bone marrow - 5 day(s) ago
Liu et al. report that common ILC progenitors in the bone marrow highly express genes that regulate the circadian clock and that the mobilization of these progenitors from the bone marrow occurs in a circadian-clock-dependent manner. Mechanistically, circadian signals regulate the bone marrow retention and emigration receptors for these ILC progenitors.
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Mashup Score: 5The mouse motor system contains multiple premotor areas and partially follows human organizational principles - 5 day(s) ago
Lazari et al. provide evidence for the existence of multiple premotor areas within the mouse motor network. Three premotor areas, ALM, aM2, and pM2, have distinct structural, functional, and behavioral properties and show important similarities to and differences from the human motor system.
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Mashup Score: 27
Auditory memory guidance for motor shaping is necessary for vocal learning. Here, Louder et al. show transient axonal projections to the song premotor area from the neurons responsive to the tutor’s song (TS) playback in the auditory forebrain. Ablating TS-responsive neurons disrupts song learning in juveniles but not in adults.
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Mashup Score: 0SH3Ps recruit auxilin-like vesicle uncoating factors for clathrin-mediated endocytosis - 6 day(s) ago
Clathrin-mediated endocytosis is a universal process in eukaryotes, but studies reveal unique aspects of its molecular mechanism in distinct lineages. Adamowski et al. report a plant-specific interaction module in clathrin-mediated endocytosis where conserved BAR-SH3 proteins recruit auxilin-like uncoating factors to vesicles.
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Mashup Score: 32
Shah et al. describe an approach to measure single-neuronal excitability at large scale in a mouse model of epilepsy in vivo and show that neuronal excitability is reduced near a seizure wavefront while remaining preserved throughout the greater seizure penumbra.
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Structural and mechanistic insights into the function of Leishmania ribosome lacking a single pseudouridine modification https://t.co/E8eyTzZ9rU