-
Mashup Score: 2Neurotropic EV71 causes encephalitis by engaging intracellular TLR9 to elicit neurotoxic IL12-p40-iNOS signaling - Cell Death & Disease - 2 year(s) ago
Brainstem encephalitis, a manifestation of severe enterovirus 71 (EV71) infection, is an acute excessive inflammatory response. The mechanisms underlying its development remain poorly understood. Usually neurotropic viruses trigger acute host immune response by engaging cell surface or intracellular receptors. Here, we show that EV71 engagement with intracellular receptor TLR9 elicits…
Source: NatureCategories: Infectious Disease, Latest HeadlinesTweet
-
Mashup Score: 5Eurosurveillance | Re-emergence of enterovirus D68 in Europe after easing the COVID-19 lockdown, September 2021 - 3 year(s) ago
We report a rapid increase in enterovirus D68 (EV-D68) infections, with 139 cases reported from eight European countries between 31 July and 14 October 2021. This upsurge is in line with the seasonality of EV-D68 and was presumably stimulated by the widespread reopening after COVID-19 lockdown. Most cases were identified in September, but more are to be expected in the coming months….
Source: www.eurosurveillance.orgCategories: Infectious Disease, Latest HeadlinesTweet-
RT @onisillos: Re-emergence of #enterovirus D68 in Europe after easing the COVID-19 lockdown, September 2021 https://t.co/98mfcTSKHt #EVD68
-
-
Mashup Score: 3Human Intestinal Organoids Recapitulate Enteric Infections of Enterovirus and Coronavirus - 3 year(s) ago
Zhao and colleagues modified the composition of differentiation medium and demonstrated that the optimized medium improves the maturation state of human intestinal organoids. Two coronaviruses, SARS-CoV-2 and SARS-CoV, and two enteroviruses, EV-A71 and CVA16, reveal distinct profiles of virus-host interaction in the optimized intestinal organoids. Overall, human intestinal organoids adequately…
Source: Stem Cell ReportsCategories: General Medicine News, Latest HeadlinesTweet-
Check out the @stemcellreports article from Zhou et al. @HKUniversity, Human Intestinal Organoids Recapitulate Enteric Infections of #Enterovirus and #Coronavirus https://t.co/0r1sDgRrnS https://t.co/i3hhj85uke
-
-
Mashup Score: 0The Lancet Infectious Diseases, March 2021, Volume 21, Issue 3, Pages 297-438, e36-e63 - 3 year(s) ago
Peruse the current issue of The Lancet Infectious Diseases, a monthly journal covering international issues relevant to clinical infectious diseases specialists worldwide
Source: www.thelancet.comCategories: Infectious Disease, Latest HeadlinesTweet-
March issue now live https://t.co/XeljAzBdUB. Featuring #tuberculosis, #COVID19, #MERS, #bacteriophage to treat #UTI, #enterovirus A71, #PCV, #cholera, #fungal keratitis, and much more. https://t.co/UIjxZMJyAC
-
-
Mashup Score: 1Enterovirus infection induces massive recruitment of all isoforms of small cellular Arf GTPases to the replication organelles - 4 year(s) ago
Enterovirus replication requires the cellular protein GBF1, a guanine nucleotide exchange factor for small Arf GTPases. When activated, Arfs associate with membranes where they regulate numerous steps of membrane homeostasis. The requirement for GBF1 implies that Arfs are important for replication, but which of the different Arfs function(s) during replication remains poorly understood. Here, we…
Source: Journal of VirologyCategories: Infectious Disease, Latest HeadlinesTweet-
🥼 Virginia-Maryland College of Veterinary Medicine (@VaMdVetMed) investigators established cell lines expressing each of the human Arfs fused to a fluorescent tag and investigated their behavior during #enterovirus #infection. https://t.co/kZeJg1sYrC https://t.co/b45vFNJKxY
-
-
Mashup Score: 32Non-Polio Enterovirus | About EV-D68 | Enterovirus D68 | CDC - 4 year(s) ago
Enterovirus D68 (EV-D68) is one of many non-polio enteroviruses.
Source: www.cdc.govCategories: General Medicine News, Latest HeadlinesTweet-
#Enterovirus is more common during summer through fall. While mostly causing common colds, enteroviruses, particularly #EVD68, may cause #AcuteFlaccidMyelitis #AFM, an uncommon but serious neurologic condition that can lead to paralysis. See: https://t.co/Cu7SC9KFNI. https://t.co/QZdFelDpfM
-
-
Mashup Score: 4Human antibodies neutralize enterovirus D68 and protect against infection and paralytic disease - 4 year(s) ago
Enterovirus D68 (EV-D68) is a human respiratory virus associated with acute flaccid myelitis, a rare paralytic disease primarily occurring in young children. To develop a potential therapeutic agent for this emerging disease, Vogt et al. screened B cells from participants with past EV-D68 infection for virus-binding antibodies and isolated a series of human monoclonal antibodies (mAbs). One mAb…
Source: Science ImmunologyCategories: Allergy-Immunology, Latest HeadlinesTweet-
.@VogtVirusLab, @croweje, @DirectorPI4D and their colleagues have identified a broadly neutralizing antibody in a patient previously infected with #enterovirus D68. Administered in mice, the antibody prevented respiratory and polio-like disease: https://t.co/lyqRzBiY8j https://t.co/2AY47G6rmi
-
-
Mashup Score: 1Human antibodies neutralize enterovirus D68 and protect against infection and paralytic disease - 4 year(s) ago
Enterovirus D68 (EV-D68) is a human respiratory virus associated with acute flaccid myelitis, a rare paralytic disease primarily occurring in young children. To develop a potential therapeutic agent for this emerging disease, Vogt et al. screened B cells from participants with past EV-D68 infection for virus-binding antibodies and isolated a series of human monoclonal antibodies (mAbs). One mAb…
Source: Science ImmunologyCategories: Allergy-Immunology, Latest HeadlinesTweet-
Potent neutralizing antibodies found in young patients with #enterovirus D68 may someday help thwart #polio -like Illness, reports a new study from @VogtVirusLab, @croweje and their colleagues at @VUMC-Vaccines, @purduepi4d: https://t.co/DTJOmqDveT #immunology https://t.co/59nLMtIUpQ
-
-
Mashup Score: 12Human antibodies neutralize enterovirus D68 and protect against infection and paralytic disease - 4 year(s) ago
Enterovirus D68 (EV-D68) is a human respiratory virus associated with acute flaccid myelitis, a rare paralytic disease primarily occurring in young children. To develop a potential therapeutic agent for this emerging disease, Vogt et al. screened B cells from participants with past EV-D68 infection for virus-binding antibodies and isolated a series of human monoclonal antibodies (mAbs). One mAb…
Source: Science ImmunologyCategories: Future of Medicine, Latest HeadlinesTweet-
Potent neutralizing antibodies found in young patients with #enterovirus D68 may someday help thwart #polio -like Illness, reports a new study from @VUMC-Vaccines, @purduepi4d. New in @SciImmunology: https://t.co/AnzeNKSTBE #immunology https://t.co/xvqlqlH2hJ
-
-
Mashup Score: 3Science Immunology - 4 year(s) ago
July 2020 Vol 5, Issue 49FocusResearch Articles TOX is expressed by exhausted and polyfunctional human effector memory CD8+ T cells By Takuya Sekine, André Perez-Potti, Son Nguyen, Jean-Baptiste Gorin, Vincent H. Wu, Emma Gostick, Sian Llewellyn-Lacey, Quirin Hammer, Sara Falck-Jones, Sindhu Vangeti, Meng Yu,…
Source: immunology.sciencemag.orgCategories: Allergy-Immunology, Latest HeadlinesTweet-
The new #July issue of Science #Immunology is out! Read about: the discovery of powerful neutralizing antibodies in patients with polio-like #enterovirus D68; another critical way that mouse models differ from humans; and more to come! https://t.co/qSYw2CWOWe https://t.co/AyjXCjVo5Q
-
How does brainstem #encephalitis manifest from severe #enterovirus 71 infection? 🧠In this new @cddpress study, scientists suggest that it does so by engaging intracellular TLR9 to elicit #neurotoxic IL12-p40-iNOS signaling. 🔗 https://t.co/6NcfbEb49I https://t.co/DkmXrPd8aE