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Mashup Score: 3Illuminating the human yolk sac through single-cell omics - Nature Reviews Genetics - 6 month(s) ago
A paper in Science reports a time-resolved multiomic atlas of the human yolk sac, expanding knowledge of this poorly resolved structure in humans.
Source: NatureCategories: Future of Medicine, Latest HeadlinesTweet
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Mashup Score: 4
Roohani et al. have developed a deep learning tool called GEARS that predicts the effects of multigene perturbations.
Source: NatureCategories: Future of Medicine, Latest HeadlinesTweet-
RT @NatureRevGenet: Predicting the effects of multigene perturbations https://t.co/KWq59FFipL #ResearchHighlight by @haertl17
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Mashup Score: 10Advancing the use of genome-wide association studies for drug repurposing - Nature Reviews Genetics - 6 month(s) ago
Genome-wide association studies (GWAS) have revealed important biological insights into complex diseases. The authors review approaches that leverage GWAS to identify opportunities for repurposing existing drugs, including single-loci mapping to drug targets, transcriptome-wide association studies, gene-set association, causal inference by Mendelian randomization and polygenic scoring.
Source: NatureCategories: Future of Medicine, Latest HeadlinesTweet-
RT @clintomics: Advancing the use of genome-wide association studies for drug repurposing | Nature Reviews Genetics https://t.co/da9yKAHdht
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Mashup Score: 17
Carla Daniela Robles-Espinoza celebrates a paper that inspired a new generation of Mexican scientists.
Source: NatureCategories: Future of Medicine, Latest HeadlinesTweet-
RT @VictorG74402417: The genome that fuelled a Mexican scientific revolution | Nature Reviews Genetics https://t.co/KixWZ6QrjZ
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Mashup Score: 1Prebiotic selection and assembly of proteinogenic amino acids and natural nucleotides from complex mixtures - Nature Chemistry - 6 month(s) ago
2-aminothiazole — a hybrid of prebiotic amino acid and nucleotide precursors — sequentially accumulates and purifies glycolaldehyde and glyceraldehyde from complex mixtures in the order required for ribonucleotide synthesis, dynamically resolves glyceraldehyde from its ketose-isomer dihydroxyacetone, and provides the first strategy to select natural amino acids from abiotic aldehydes and ketones.
Source: NatureCategories: Infectious Disease, Latest HeadlinesTweet-
RT @UrnovFyodor: @leecronin The first 21 citations in this paper will do a better job than I will. https://t.co/efer9u2PLX
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Mashup Score: 7Perfecting antibodies with language models - Nature Biotechnology - 6 month(s) ago
A general-purpose protein language model rapidly improves antibody properties.
Source: NatureCategories: Future of Medicine, Latest HeadlinesTweet-
@StanfordBiochem @Stanford_ChEMH @StanfordUChem @StanfordMed @Stanford @czbiohub Perfecting antibodies with language models #NBTNV https://t.co/ldHbalk4vY https://t.co/sR6fqFSjJm
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Mashup Score: 56The chemistry of next-generation sequencing - Nature Biotechnology - 6 month(s) ago
A historical perspective on how next-generation sequencing chemistry was developed.
Source: NatureCategories: Future of Medicine, Latest HeadlinesTweet-
The chemistry of next-generation sequencing https://t.co/PXVEquudyn https://t.co/thsctw8bG8
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Mashup Score: 3Sir Ian Wilmut 1944–2023 - Nature Biotechnology - 6 month(s) ago
Nature Biotechnology – Sir Ian Wilmut 1944–2023
Source: NatureCategories: Future of Medicine, Latest HeadlinesTweet-
Sir Ian Wilmut 1944–2023 https://t.co/mI390R2t46 https://t.co/zsK5IRX3hz
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Mashup Score: 2Nature Reviews Genetics - Volume 24 Issue 11, November 2023 - 6 month(s) ago
Inspired by the Review on p739
Source: NatureCategories: Future of Medicine, Latest HeadlinesTweet-
Our November 2023 issue is now live: https://t.co/92eItlOIX2 Topics include computational tools for gene regulatory networks; genomic sequencing in newborn screening; the role of coactivators in transcriptional activation; genomic imprinting and parenting behaviour in mammals
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Mashup Score: 3Gene regulatory network inference in the era of single-cell multi-omics - Nature Reviews Genetics - 6 month(s) ago
Regulatory circuits of gene expression can be represented as gene regulatory networks (GRNs) that are useful to understand cellular identity and disease. Here, the authors review the computational methods used to infer GRNs — in particular from single-cell multi-omics data — as well as the biological insights that they can provide, and methods for their downstream analysis and experimental…
Source: NatureCategories: Future of Medicine, Latest HeadlinesTweet-
Our Featured article: Gene regulatory network inference in the era of single-cell multi-omics https://t.co/8eTnxmU3zF #Review by @PauBadiaM, @LornaWessels, @sophia_mullerd, @TrimbourR, @roramirezf94, @RArgelaguet & @saezlab @UniHeidelberg
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RT @NatureRevGenet: Illuminating the human yolk sac through single-cell omics https://t.co/KyISDlEXl5 #ResearchHighlight