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Mashup Score: 2Decomposing virulence to understand bacterial clearance in persistent infections - Nature Communications - 2 year(s) ago
The relationship between virulence and pathogen clearance is not well understood. Here, using bacterial infections in Drosophila melanogaster as a model system, the authors demonstrate an approach to disentangle the drivers of virulence and assess their relation to pathogen clearance rate.
Source: NatureCategories: General Medicine News, Latest HeadlinesTweet
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Mashup Score: 0
Author summary Pathogens must express their virulence genes at precisely the right time to cause disease. Here, we identify a novel small protein that governs a critical virulence program in the pathogen Salmonella enterica serovar Typhimurium (S. Typhimurium). We establish that the novel small protein UgtS prevents the virulence protein UgtL from activating the master virulence regulator PhoP…
Source: journals.plos.orgCategories: Genetics, Latest HeadlinesTweet-
New research on #Salmonella virulence: Salvail et al identify a new protein that governs a critical virulence program They show how a horizontally acquired gene can control ancestral regulators to time #virulence programs https://t.co/ZjE06si4AN
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Mashup Score: 7Direct interaction of a chaperone-bound type III secretion substrate with the export gate - Nature Communications - 2 year(s) ago
Recruitment of substrates to virulent bacterial type III secretion systems remains enigmatic. Here, a crystal structure reveals two binding sites between a secretion substrate in complex with its chaperone and the cytosolic domain of the export gate.
Source: NatureCategories: General Medicine News, Latest HeadlinesTweet-
Researchers from @unibielefeld report a structure of a secretion substrate in complex with its chaperone and the export gate of virulent bacterial type III secretion system. #T3SS #structuralbiology #ProteinCrystallography #yersinia #virulence #Donuts https://t.co/XCQxp68ZiO https://t.co/SbuHrFLDfs
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Mashup Score: 4
Author summary Pathogens must express their virulence genes at precisely the right time to cause disease. Here, we identify a novel small protein that governs a critical virulence program in the pathogen Salmonella enterica serovar Typhimurium (S. Typhimurium). We establish that the novel small protein UgtS prevents the virulence protein UgtL from activating the master virulence regulator PhoP…
Source: journals.plos.orgCategories: Genetics, Latest HeadlinesTweet-
New research on #Salmonella virulence: Salvail et al @BertSalvail @MicrobeLab identify a new protein that governs a critical virulence program They show how a horizontally acquired gene can control ancestral regulators to time #virulence programs https://t.co/ZjE06szFZn
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Mashup Score: 5Emerging SARS-CoV-2 variants of concern and potential intervention approaches - Critical Care - 3 year(s) ago
The major variant of concerns (VOCs) have shared mutations in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike proteins, mostly on the S1 unit and resulted in higher transmissibility rate and affect viral virulence and clinical outcome. The spike protein mutations and other non-structural protein mutations in the VOCs may lead to escape approved vaccinations in certain extend….
Source: Critical CareCategories: Critical Care, Latest HeadlinesTweet-
#CritCare #OA #COVID_19 variants & vaccines with an eye on immune host response! https://t.co/1Q1mXjDL7F #FOAMed #FOAMcc #BMC @ ISICEM @jlvincen #Sars_Cov_2 #infection #immune_escape #spike_protein #virulence #transmissibility https://t.co/9UOXcrZoiQ
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Mashup Score: 1Fungal and host protein persulfidation are functionally correlated and modulate both virulence and antifungal response - 3 year(s) ago
This study reveals that the post-translational modification persulfidation is important for both fungal virulence and the host antifungal response. The level of persulfidation in the host, which correlates with its antifungal potency, impacts the level required in the fungus to counteract host attack, reflecting a functional correlation. Thus modulating persulfidation may be a promising strategy…
Source: journals.plos.orgCategories: Infectious Disease, Latest HeadlinesTweet-
Dr. Jorge Amich's team at @hsrc_manchester reveal in their new @PLOSBiology paper that #fungal and host protein persulfidation are functionally correlated and modulate both #virulence and antifungal response. https://t.co/ROEFcSCaRG https://t.co/J2z8ymDOo9
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Mashup Score: 1A Defense Pathway Linking Plasma Membrane and Chloroplasts and Co-opted by Pathogens - 4 year(s) ago
Unrelated effector proteins from viral and bacterial pathogens infecting plants co-opt an endogenous pathway to dynamically translocate from the plasma membrane to chloroplasts in the host cell and suppress salicylic-acid-dependent plant defence responses
Source: CellCategories: General Medicine Journals and Societies, Latest HeadlinesTweet-
#Plant #pathogens co-opt #defense pathways to promote #virulence through suppression of plant #immune responses. https://t.co/PRodH0DCiC @PscGemini https://t.co/TImySvLbv1
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Mashup Score: 9A Defense Pathway Linking Plasma Membrane and Chloroplasts and Co-opted by Pathogens - 4 year(s) ago
Unrelated effector proteins from viral and bacterial pathogens infecting plants co-opt an endogenous pathway to dynamically translocate from the plasma membrane to chloroplasts in the host cell and suppress salicylic-acid-dependent plant defence responses
Source: CellCategories: General Medicine Journals and Societies, Latest HeadlinesTweet-
Online now! #Plant #pathogens co-opt a #defense pathway to promote #virulence through suppression of plant #immune responses https://t.co/3BsZ0afkH5 https://t.co/tvgdN0U6V2
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Mashup Score: 0
The process by which RNA viruses, such as influenza virus, cleave capped host transcripts to drive viral mRNA production leads to the translation of host and viral RNA to make hybrid proteins that then generate T cell responses and contribute to virulence.
Source: CellCategories: General Medicine Journals and Societies, Latest HeadlinesTweet-
The process by which #RNA #viruses cleave capped host transcripts leads to #hybrid proteins that generate #Tcell responses and contribute to #virulence. Read more in the latest issue out now!-> https://t.co/7V66jvC5oe @IcahnMountSinai https://t.co/AN6MtxevpI
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Mashup Score: 7
The process by which RNA viruses, such as influenza virus, cleave capped host transcripts to drive viral mRNA production leads to the translation of host and viral RNA to make hybrid proteins that then generate T cell responses and contribute to virulence.
Source: CellCategories: General Medicine Journals and Societies, Latest HeadlinesTweet-
Now Online! The process by which #RNA #viruses cleave capped host transcripts leads to #hybrid proteins that generate T cell responses and contribute to #virulence. https://t.co/fYu0GrZR7t https://t.co/SPHTP8jenb
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.@_BeaAcuna_ et al. use bacterial infections in Drosophila as a model system, to demonstrate an approach to disentangle the drivers of virulence and assess their relation to pathogen clearance rate https://t.co/aPqOlRKJ28 #virulence #drosophila .@luismmsilva_