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Mashup Score: 6
What are the molecular targets of inhaled anesthetics, such as isoflurane? This study reports that isoflurane binds type 1 ryanodine receptor, and determines that genetically disrupting a specific residue or pharmacologically activating this binding site with novel agonists can modulate sensitivity to anesthesia.
Source: journals.plos.orgCategories: General Medicine News, NeurologyTweet
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Mashup Score: 24Clinical efficacy of different therapeutic options for knee osteoarthritis: A network meta-analysis based on randomized clinical trials - 16 day(s) ago
Objective To assess and compare the clinical efficacy of various therapeutic options in treating patients with knee osteoarthritis (KOA). Methods We performed a comprehensive search of PubMed, Embase, OVID, Cochrane Library and Web of Science databases from their inception to December 10th, 2023, identifying randomized controlled trials (RCTs) examining the effects of therapeutic options on KOA. Two researchers independently performed literature screening, data extraction, data collection and organization, and quality assessment. The data obtained were subjected to statistical analysis and graphical representation using Stata 17.0 software. Results A total of 139 RCTs encompassing 9644 KOA patients and involving 12 therapeutic options were included. These interventions were low level laser therapy (LLLT), high intensity laser therapy (HILT), transcutaneous electrical nerve stimulation (TENS), interferential current (IFC), short wave diathermy, ultrasound, lateral wedged insole, knee br
Source: journals.plos.orgCategories: General Medicine NewsTweet
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Mashup Score: 13Interleaved single and bursting spiking resonance in neurons - 18 day(s) ago
Author summary Since the discovery that neurons in the hippocampus can encode spatial position through phase precession, many experiments have explored how specific theta and gamma oscillations influence location specificity in the brain. However, the individual neuronal properties and dynamics behind these behaviors are still being uncovered. Previously, we found that stereotypical bursting and single-spike firing in pyramidal neurons are linked to these oscillations and further associated with an animal entering or leaving a place field. Advances in voltage-imaging techniques have enabled us to assess these properties more precisely. Our study shows that different frequencies can independently trigger these stereotypical spikes, demonstrating a complex pattern where the same cell can be double-coded: a phenomenon we called interleaved resonance. Additionally, we found that this coding can be modulated by persistent sodium and delayed-rectifier potassium currents. Moreover, these neur
Source: journals.plos.orgCategories: General Medicine News, NeurologyTweet
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Mashup Score: 7SQST-1/p62-regulated SKN-1/Nrf mediates a phagocytic stress response via transcriptional activation of lyst-1/LYST - 22 day(s) ago
Author summary During development, cells can have many fates, one of which is to deliberately die. If a cell’s inherent ability to die is lost, unwanted cells remain, which can lead to pathologies such as abnormal brain development or cancer. Dead cell remains must also be fully and efficiently cleared away by being ingested and digested by other cells, to avoid autoimmunity. Cells that are destined to die, like any cell, can also be subject to stress, which can change cell behavior. Moreover, cells fated to die often have highly intricate shapes, such as nerve cells in the brain, and their removal may entail different strategies for different regions of the cell. In this study, we have used the pre-destined “3-in-1” death of a structurally-complex cell in the roundworm C. elegans as a platform to describe the genetics behind how one cell bolsters its inherent ability to consume an area of another dying cell by mounting a response to environmental stress. Specifically, we report, to ou
Source: journals.plos.orgCategories: General Medicine News, NeurologyTweet
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Mashup Score: 6Embodiment of an artificial limb in mice - 29 day(s) ago
Body ownership disorders can be triggered by disease or body damage in humans. This study shows, using an automated, videography-based procedure, that mice also display quantifiable behavioral markers of the embodiment of an artificial limb, opening the door to future research on these disorders.
Source: journals.plos.orgCategories: General Medicine News, NeurologyTweet
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Mashup Score: 6Throwbacks that move us: The dance-inducing power of nostalgic songs - 1 month(s) ago
The urge to move to music, often referred to as groove, is influenced by various factors, including familiarity with the music. The influence of nostalgia, which involves familiarity but also includes pleasant, sad, and wistful emotions, remains largely unexplored. Here we investigate the impact of both familiarity and nostalgia on the desire to tap, move, and dance along to music. To evoke nostalgia, we selected popular songs from the participants’ adolescent years. More recent songs served as a low-nostalgia but familiar control. Participants completed an online experiment, rating songs based on their desire for three different movement types (tap, move, and dance), as well as enjoyment, familiarity, and nostalgia. Nostalgic songs elicited higher desire to move than familiar songs across all three movement categories. Additionally, both familiarity and nostalgia predicted move and tap ratings, but only nostalgia emerged as a predictor for dance ratings. Our results suggest a distinct
Source: journals.plos.orgCategories: General Medicine News, NeurologyTweet
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Mashup Score: 6The impact of health inequity on spatial variation of COVID-19 transmission in England - 1 month(s) ago
Author summary During the COVID-19 pandemic, different geographic areas of England saw different patterns in the number of confirmed cases over time. This study investigated whether demographic differences between these areas (such as the amount of deprivation, the age and ethnicity of the populations, or differences in where people spent their time) were linked to these differences in disease transmission. We also considered whether this was associated with the number of cases in neighbouring areas as well. Using a mathematical model fit to multiple data streams, we discovered that a statistically significant link between some demographic variables (time spent at home, COVID-19 variant, and the amount of adult social care funding) and week-to-week transmission exists, but this relationship is very small, and the influence of cases in neighbouring areas was far more impactful in explaining differences in transmission between areas over time.
Source: journals.plos.orgCategories: General Medicine News, Infectious DiseaseTweet
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Mashup Score: 0
Medical journals have become dependent on the pharmaceutical industry for their survival, which can have a corrupting influence on their content, argues Smith, the former editor of the BMJ.
Source: journals.plos.orgCategories: General Medicine NewsTweet
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Mashup Score: 7Determinants of subjective total athletic ability - 1 month(s) ago
The term “good motor skill” is often discussed in everyday contexts and when observing sports; however, its definition remains elusive, and the associated factors are not well understood. Therefore, in this cross-sectional study, we investigated the determinants of subjective total athletic ability, defined as the sum of subjective athletic abilities across 11 sports disciplines. A sample of 406 undergraduate students completed a questionnaire to evaluate their perceived athletic prowess in various sports, as well as assessments of their personality traits, family background, and sports performance. The analysis revealed correlations between the perceived general athletic ability and specific abilities in soccer, volleyball, basketball, and short-distance racing. Furthermore, linear model analyses indicated a positive association between perceived total athletic ability and personal characteristics such as grit, resilience, and a growth mindset. Factors such as recreational activities
Source: journals.plos.orgCategories: General Medicine News, NeurologyTweet
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Mashup Score: 9Behavioral responses of domestic cats to human odor - 1 month(s) ago
People all around the world live with cats and cats engage in many social behaviors toward their owners. Olfaction is one of the most important sensory abilities in cats, yet its role in recognizing humans remains unclear. In this study, we assessed the role and characteristics of olfaction in the discrimination of known or unknown humans by cats using ethological methods. Whether cats exhibit a lateralization of nostril use in response to a variety of olfactory stimuli, exposure experience, inter alia, was investigated. Cats were simultaneously presented with three odor stimuli: that of a known person (owner), an unknown person, and a blank control. Responses to the cat 2 scale (Feline Five) and the cat–owner relationship scale (CORS) were collected from cat owners through questionnaires. It was observed that cats spent a substantially longer time sniffing the odor of an unknown person than that of a known person, indicating the use of their sense of smell to distinguish between heter
Source: journals.plos.orgCategories: General Medicine News, NeurologyTweet
“Isoflurane activates the type 1 ryanodine receptor to induce anesthesia in mice” by Hiroki R. Ueda et al. PLOS Biology https://t.co/uCgWW8ensr