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Mashup Score: 2The tumour histopathology “glossary” for AI developers - 2 day(s) ago
The applications of artificial intelligence (AI) and deep learning (DL) are leading to significant advances in cancer research, particularly in analysing histopathology images for prognostic and treatment-predictive insights. However, effective translation of these computational methods requires computational researchers to have at least a basic understanding of histopathology. In this work, we aim to bridge that gap by introducing essential histopathology concepts to support AI developers in their research. We cover the defining features of key cell types, including epithelial, stromal, and immune cells. The concepts of malignancy, precursor lesions, and the tumour microenvironment (TME) are discussed and illustrated. To enhance understanding, we also introduce foundational histopathology techniques, such as conventional staining with hematoxylin and eosin (HE), antibody staining by immunohistochemistry, and including the new multiplexed antibody staining methods. By providing this es
Source: journals.plos.orgCategories: General Medicine News, Oncologists1Tweet
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Mashup Score: 0
Background Glyphosate, as the main component of glyphosate pesticides, has been shown to have toxic effects on multiple human systems. However, the association between glyphosate and atherosclerotic cardiovascular disease (ASCVD) remains unclear. This study aims to explore the effect of glyphosate exposure on ASCVD. Methods This study involved 1,602 participants and employed various statistical techniques, such as multivariable logistic regression, linear fitting, mediation analysis, subgroup analysis, and sensitivity analysis, to elucidate the association between glyphosate exposure and cardiovascular diseases. Results Compared with the low level of glyphosate exposure, the risk of ASCVD increased significantly with high level of glyphosate exposure (OR = 2.05, 95%CI = 1.17–3.58, p<0.05, p for trend<0.05), which showed a linear upward trend. Further analysis found that exposure to high levels of glyphosate and angina pectoris (OR = 2.84, 95%CI = 1.00–8.04, p<0.05, p for trend<0.05), c
Source: journals.plos.orgCategories: General Medicine News, Partners & KOLsTweet-
BMI-mediated association between glyphosate exposure and increased risk of ... - PLOS - https://t.co/4uI99e9raB
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Mashup Score: 427
In a population-based case-control study, Raphael Peter and colleagues investigate the clinical characteristics and diagnostic findings in patients with post-COVID-19 syndrome.
Source: journals.plos.orgCategories: General Medicine News, Expert PicksTweet-
The persistence of #LongCovid at 2 years in a prospective cohort of ~1,000 affected individuals with matched controls, with multi-system objective assessments including cognitive testing, lung function, and exercise capacity https://t.co/Bf0ArhsSON open-access https://t.co/4d1m81zeuF
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Mashup Score: 427
In a population-based case-control study, Raphael Peter and colleagues investigate the clinical characteristics and diagnostic findings in patients with post-COVID-19 syndrome.
Source: journals.plos.orgCategories: General Medicine News, Expert PicksTweet-
The persistence of #LongCovid at 2 years in a prospective cohort of ~1,000 affected individuals with matched controls, with multi-system objective assessments including cognitive testing, lung function, and exercise capacity https://t.co/Bf0ArhsSON open-access https://t.co/4d1m81zeuF
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Mashup Score: 427
In a population-based case-control study, Raphael Peter and colleagues investigate the clinical characteristics and diagnostic findings in patients with post-COVID-19 syndrome.
Source: journals.plos.orgCategories: General Medicine News, Expert PicksTweet-
The persistence of #LongCovid at 2 years in a prospective cohort of ~1,000 affected individuals with matched controls, with multi-system objective assessments including cognitive testing, lung function, and exercise capacity https://t.co/Bf0ArhsSON open-access https://t.co/4d1m81zeuF
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Mashup Score: 21A pan-orthohantavirus human lung xenograft mouse model and its utility for preclinical studies - 7 day(s) ago
Author summary Orthohantaviruses are rodent-borne pathogens that can be transmitted from rodents to humans by inhalation of aerosolized virus-contaminated rodent excreta. While orthohantaviruses generally do not cause overt clinical signs in rodents, orthohantavirus infection can lead to severe disease with case fatality rates up to 40%. The pathogenesis of associated hemorrhagic fever with renal syndrome (HFRS) mainly in Europe and Asia and hantavirus cardiopulmonary syndrome (HCPS) in the Americas remains poorly understood. Particularly the understanding of the early steps of pathogenesis occurring in the human lungs is limited. In addition, assessment of the efficacy of cross-reactive anti-orthohantavirus antibodies is severely hampered by the limited availability of in vivo models that allow for replication of both HFRS- and HCPS-associated orthohantaviruses within the same animal model. Therefore, we present a human lung xenograft mouse model to study early events of orthohantavir
Source: journals.plos.orgCategories: General Medicine News, Infectious DiseaseTweet-
https://t.co/SKwfR6X2Av A model to study impact of viruses in human respiratory tissue.
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Mashup Score: 21A pan-orthohantavirus human lung xenograft mouse model and its utility for preclinical studies - 7 day(s) ago
Author summary Orthohantaviruses are rodent-borne pathogens that can be transmitted from rodents to humans by inhalation of aerosolized virus-contaminated rodent excreta. While orthohantaviruses generally do not cause overt clinical signs in rodents, orthohantavirus infection can lead to severe disease with case fatality rates up to 40%. The pathogenesis of associated hemorrhagic fever with renal syndrome (HFRS) mainly in Europe and Asia and hantavirus cardiopulmonary syndrome (HCPS) in the Americas remains poorly understood. Particularly the understanding of the early steps of pathogenesis occurring in the human lungs is limited. In addition, assessment of the efficacy of cross-reactive anti-orthohantavirus antibodies is severely hampered by the limited availability of in vivo models that allow for replication of both HFRS- and HCPS-associated orthohantaviruses within the same animal model. Therefore, we present a human lung xenograft mouse model to study early events of orthohantavir
Source: journals.plos.orgCategories: General Medicine News, Infectious DiseaseTweet-
https://t.co/SKwfR6X2Av A model to study impact of viruses in human respiratory tissue.
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Mashup Score: 2In vivo mapping of sodium homeostasis disturbances in individual ALS patients: A brain 23Na MRI study - 7 day(s) ago
Objective Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by significant heterogeneity among patients. 23Na MRI maps abnormal sodium homeostasis that reflects metabolic alterations and energetic failure contributing to the neurodegenerative process. In this study, we investigated disease severity at the individual level in ALS patients using brain 23Na MRI. Methods 1H and 23Na brain MRI were collected prospectively from 28 ALS patients. Individual map of abnormal total sodium concentration (TSC) was computed using voxel-based statistical mapping for each patient compared to a local database of 62 healthy controls. Clinical data included the revised ALS functional rating scale (ALSFRS-R), ALSFRS-R slope, ALSFRS-R at 6-month and survival time. Results Individual maps quantifying voxels with TSC increase evidenced a high heterogeneity between patients consistent with clinical presentation. The main areas involved were the corticospinal tracts. Half of pati
Source: journals.plos.orgCategories: General Medicine News, NeurologyTweet-
"These findings suggest that total sodium concentration increase detected at the individual level by 23Na MRI may be a useful marker of the clinical heterogeneity of ALS" https://t.co/wTvDNxbiHn
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Mashup Score: 3
Short videos have gained widespread popularity among elementary school students in China. As a form of entertainment media, their usage has steadily increased among adolescents in recent years. This phenomenon has sparked extensive discussions in society, especially against Chinese parents’ high concern for their children’s academic performance. Therefore, this study collected 1052 valid questionnaires from elementary school students, attempting to explore the possibility that their short video usage might negatively impact their academic performance. Besides, the mechanism of this relationship was also examined from the perspective of children’s attention and environmental factors of parents’ short video usage. The research findings indicate that the more elementary school students use short videos, the lower their academic performance, with attention mediating in this relationship. The longer the parental short video usage duration, the exacerbating effect it has on elementary school
Source: journals.plos.orgCategories: General Medicine News, General HCPsTweet-
The relationship between short video usage and academic achievement among elementary school students: The mediating effect of attention and the moderating effect of parental short video usage | PLOS ONE https://t.co/MVRvbbvH65
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Mashup Score: 44
Karin Källén and colleagues evaluate maternal and neonatal outcomes after a national change in the management of late-term pregnancies in Sweden, hypothesising that early induction improves perinatal outcomes.
Source: journals.plos.orgCategories: General Medicine News, General HCPsTweet-
#Revised induction procedures in Sweden have led to a 47% reduction in #InfantMortality for pregnancies extending beyond 41 weeks. This change highlights the impact of proactive management. @plosmedicine https://t.co/QfT6QbNwRs https://t.co/MV2CqHilg8
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Are you using #AI to analyse #Histopathology images? A team of ICR researchers have created a glossary to help AI developers understand tumour histopathology. They hope that this will speed up the development of AI algorithms for cancer research ⤵️ https://t.co/quSs0CFGxV