Kalluri and McAndrews review the function of EVs and exosomes in the context of cancer progression and metastasis, their utility as biomarkers for early detection of cancer, as well as their use as therapeutic agents and a delivery system for various types of therapies that are currently in clinical evaluation.

Metastasis is the most lethal manifestation of cancer, but our understanding of its biology and how to effectively treat it is rapidly advancing. This review highlights established and emerging principles of metastasis and provides a framework to develop more effective therapies for metastatic cancer.

A revised framework for tumor initiation and promotion provides fresh insight into strategies for early cancer prevention.

Decades of oncologic clinical use have demonstrated that cancer immunotherapy provides unprecedented therapeutic benefits. Tragically, only a minority of patients respond to existing immunotherapies. RNA lipid nanoparticles have recently emerged as modular tools for immune stimulation. Here, we discuss advancements in RNA-based cancer immunotherapies and opportunities for improvement.

The nervous system plays a regulatory role in cancers via direct neuronal-cancer communication and indirect interactions through the immune system and cells in the tumor microenvironment. This review provides a comprehensive view of the reciprocal interactions of central and peripheral nervous system with cancers, highlighting opportunities for cancer therapy.

Solid tumors are composed of a complex and dynamic collection of cell types. Here I discuss the important relationships between cancer cells and bacterial members of the intratumoral microbiota that may provide a fitness advantage within the tumor ecological niche.

The high and increasing prices of cancer drugs are a public health challenge. This commentary examines the factors that influence cancer drug pricing and develops policy recommendations for how the rising costs can be curbed to improve patient access to cancer drugs.

Our understanding of tumorigenesis and cancer progression as well as clinical therapies for different cancer types have evolved dramatically in recent years. However, even with this progress, there are big challenges for scientists and oncologists to tackle, ranging from unpacking the molecular and cellular mechanisms involved to therapeutics and biomarker development to quality of life in the…

Enabled by technological development on various fronts, our understanding of the complexity in the biology of pancreatic ductal adenocarcinoma deepens, laying the foundation for promising translation of the biological insights into clinically actionable advances.