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Mashup Score: 0Small molecules in the treatment of COVID-19 - Signal Transduction and Targeted Therapy - 1 year(s) ago
The outbreak of COVID-19 has become a global crisis, and brought severe disruptions to societies and economies. Until now, effective therapeutics against COVID-19 are in high demand. Along with our improved understanding of the structure, function, and pathogenic process of SARS-CoV-2, many small molecules with potential anti-COVID-19 effects have been developed. So far, several antiviral…
Source: NatureCategories: Infectious Disease, Latest HeadlinesTweet
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Mashup Score: 40Structure-based discovery of small molecules that disaggregate Alzheimer’s disease tissue derived tau fibrils in vitro - Nature Communications - 2 year(s) ago
Evidence suggests that fibrous aggregates of protein tau may be the proximal cause of Alzheimer’s disease. Here, using atomic structures of tau fibrils from brains of people with Alzheimer’s disease, the authors have found small-molecule drug leads that disaggregate tau fibrils in vitro.
Source: NatureCategories: General Medicine News, Latest HeadlinesTweet-
Newly identified #smallmolecules break amyloid tangles that cause Alzheimer's @NatureComms https://t.co/GTSfR02orp https://t.co/thdfkRJPtj
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Mashup Score: 0Opportunities for Small Molecules in Cancer Immunotherapy - 4 year(s) ago
Cancer immunotherapy has proven remarkably successful through instigation of systemic antitumor T cell responses. Despite this achievement, further advancements are needed to expand the scope of susceptible cancer types and overcome variation in treatment outcomes between patients. Small-molecule drugs targeting defined pathways and/or cells capable of immune modulation are expected to…
Source: Trends in ImmunologyCategories: General Medicine News, Latest HeadlinesTweet-
Read the Review @TrendsImmuno on Opportunities for #SmallMolecules in #Cancer #Immunotherapy, by Sabina Y. van der Zanden, Jolien J. Luimstra, Jacques Neefjes, Jannie Borst & Huib Ovaa (in memoriam) https://t.co/9x3ZAw5HZi #AACR20 https://t.co/iPrxLMrKWW
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Mashup Score: 0Issue: Trends in Immunology - 4 year(s) ago
Ger Rijkers: Persistence of Memory in Times of COVID-19In a review paper published 20 years ago, Rolf Zinkernagel asked the question: Why do we need immunological memory [1]? His argument was that if you and your immune system survived a given infection once, then why wouldn’t you survive it a second time? You wouldn’t need a better response for that. And of course, if you did not survive the…
Source: www.cell.comCategories: Infectious Disease, Latest HeadlinesTweet-
@TrendsImmuno June issue is out!! #Circadian & #Diet & #Microbiome & #Immunity, #HIV, #virus infections & #vaccination, #COVID19, #skeletal #muscle #regeneration & #macrophages, #smallmolecules & #immunotherapy, #resident #memory #Tcells & more! https://t.co/vOK32N3P1N https://t.co/F2G19rZ4qJ
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Mashup Score: 5Opportunities for Small Molecules in Cancer Immunotherapy - 4 year(s) ago
Cancer immunotherapy has proven remarkably successful through instigation of systemic antitumor T cell responses. Despite this achievement, further advancements are needed to expand the scope of susceptible cancer types and overcome variation in treatment outcomes between patients. Small-molecule drugs targeting defined pathways and/or cells capable of immune modulation are expected to…
Source: Trends in ImmunologyCategories: Allergy-Immunology, Latest HeadlinesTweet-
New FREE Review @TrendsImmuno on Opportunities for #SmallMolecules in #Cancer #Immunotherapy, by Sabina Y. van der Zanden, Jolien J. Luimstra, Jacques Neefjes, Jannie Borst & Huib Ovaa (in memoriam) https://t.co/z2exSkIssR https://t.co/7IoL1VYdbl
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Brush up on current findings in the development of #SmallMolecules for #COVID19 treatment, including their detailed mechanism of action, chemical structures, and preclinical/clinical efficacy. 💊 #OpenAccess review ⤵️ https://t.co/fHBs7BgG7r https://t.co/GpyjBp6LEC