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Mashup Score: 2
Growing knowledge of the human microbiome, fueled by recent advances in genome sequencing, has pushed biomedicine to a new frontier, focused on the effect of the microbiome on health and disease. In addition to bacteria, which are the focus of this review, the human microbiota also includes fungi, protozoa, archaea, and viruses [1–3]. Estimated to harbor a hundred times more unique genes than the…
Source: Trends in ImmunologyCategories: General Medicine News, Latest HeadlinesTweet
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Mashup Score: 1Genotype–phenotype landscapes for immune–pathogen coevolution - 1 year(s) ago
Our adaptive immune systems are engaged in a continuous coevolutionary struggle with the pathogens that attack us [1,2]. This immune–pathogen coevolution takes place across a range of spatial and temporal scales: evolution in individual infections is driven by interactions between pathogens and an individual host immune system, often over the course of days or weeks, while global pathogen…
Source: Trends in ImmunologyCategories: Infectious Disease, Latest HeadlinesTweet
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Mashup Score: 5
Functional persistence of chimeric antigen receptor (CAR) T cells is required for sustaining an antitumor response. Recently, Jain et al. revealed that disruption of TET2 in CAR T cells resulted in antigen-independent CAR T cell hyperproliferation that enhanced tumor control in mice, highlighting the potential of epigenetic strategies to improve T cell-based cancer immunotherapy.
Source: Trends in ImmunologyCategories: Allergy-Immunology, Latest HeadlinesTweet
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Mashup Score: 0Genetic conflicts and the origin of self/nonself-discrimination in the vertebrate immune system - 1 year(s) ago
All forms of life are prone to attack by genetic parasites. To defend themselves against these invaders, host cells and organisms have evolved myriad self/nonself recognition systems. It appears that many of the strategies used by the cell-autonomous innate immune system to fend off viral predators have their origin in prokaryotes. For instance, DNA-sensing systems, such as the cGAS-STING pathway…
Source: Trends in ImmunologyCategories: Allergy-Immunology, Latest HeadlinesTweet
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Mashup Score: 7p53 regulates the mitochondrial immune checkpoint - 1 year(s) ago
Mitochondrial outer membrane permeabilization (MOMP) is crucial for the cytosolic accumulation of mitochondrial DNA (mtDNA) species that are required to jumpstart innate and adaptive immunity. Recent data reported by Ghosh et al. suggest that tumor protein p53 regulates MOMP-dependent type I interferon (IFN) production, not only via MOMP-promoting effects, but also by directing mtDNA-degrading…
Source: Trends in ImmunologyCategories: Hem/Oncs, Latest HeadlinesTweet
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Mashup Score: 6p53 regulates the mitochondrial immune checkpoint - 1 year(s) ago
Mitochondrial outer membrane permeabilization (MOMP) is crucial for the cytosolic accumulation of mitochondrial DNA (mtDNA) species that are required to jumpstart innate and adaptive immunity. Recent data reported by Ghosh et al. suggest that tumor protein p53 regulates MOMP-dependent type I interferon (IFN) production, not only via MOMP-promoting effects, but also by directing mtDNA-degrading…
Source: Trends in ImmunologyCategories: Allergy-Immunology, Latest HeadlinesTweet
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Mashup Score: 0
Some of the current and former organizers of the Cold Spring Harbor Laboratory (CSHL) ‘Gene Expression and Signaling in the Immune System’ (GESIS) meeting offer opinions on emerging questions in immunology, discussing the strong value of this recurring scientific meeting in the field.
Source: Trends in ImmunologyCategories: Allergy-Immunology, Latest HeadlinesTweet
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Mashup Score: 3Exhausted CD8+ T cells face a developmental fork in the road - 1 year(s) ago
CD8+ T cells play a crucial role in eliminating virus-infected cells and tumors. Armed with potent cytolytic potential and an inherent capacity to produce proinflammatory cytokines, CD8+ T cells are generally highly effective at killing their target cells upon T cell receptor (TCR) recognition of cognate antigen presented in the context of MHC-I [1]. However, in response to persistent antigen…
Source: Trends in ImmunologyCategories: Allergy-Immunology, Latest HeadlinesTweet
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Mashup Score: 2Programming cytomegalovirus as an HIV vaccine - 1 year(s) ago
Over the past 40 years of HIV-1/HIV vaccine development research, two key points have become abundantly clear. First, adaptive immune vulnerabilities of HIV and its simian counterpart SIV are few and far between due to both exquisite immune evasion adaptions of this viral family and, in humans, striking global viral sequence diversity [1–7]. The former includes hiding vulnerable envelope…
Source: Trends in ImmunologyCategories: Allergy-Immunology, Latest HeadlinesTweet
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Mashup Score: 2Virus-associated fungal infections and lost immune resistance - 1 year(s) ago
The World Health Organization (WHO) has recently updated its critical fungal pathogen list that includes Aspergillus fumigatus, Candida albicans, Candida auris, and Cryptococcus neoformans, which predominantly impact on human health by causing invasive infections, and for which treatment challenges include very high mortalities worldwide, ranging from 20% to 100% despite antifungal therapy [1]….
Source: Trends in ImmunologyCategories: Allergy-Immunology, Latest HeadlinesTweet
Read Ghaith Bakdash's review "The heightened importance of the microbiome in cancer immunotherapy" @MicrobioticaLtd @TrendsImmuno #AACR23 https://t.co/DvJKDcZw9b