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Mashup Score: 2TGF-β uncouples glycolysis and inflammation in macrophages and controls survival during sepsis - 9 month(s) ago
TGF-β induces a distinct macrophage phenotype that promotes coagulation and worsens survival during sepsis.
Source: www.science.orgCategories: Future of Medicine, Latest HeadlinesTweet
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Mashup Score: 0
Artesunate (ART) is a derivative of artemisinin. Compared with artemisinin, ART has excellent water solubility, high stability and oral bioavailability. In this review, the application of ART in classic autoimmune diseases such as rheumatoid arthritis, systemic lupus erythematosus and ulcerative colitis is summarized. ART exhibited similar or even better efficacy than other highly effective immunosuppressive agents, such as methotrexate and cyclophosphamide. In addition, ART exerts its pharmacological effects mainly by inhibiting the production of inflammatory factors, reactive oxygen species, autoantibodies and the migration of cells to reduce damage to tissues or organs. Moreover, ART widely affected the NF-κB, PI3K/Akt, JAK/STAT and MAPK pathways to exert pharmacological effects.
Source: www.futuremedicine.comCategories: Hem/Onc News and Journals, Latest HeadlinesTweet-
Artesunate exerts its pharmacological effects mainly through #NF-κB, #PI3K/Akt, #JAK/ STAT, #MAPK pathways, and is also widely involved in the regulation of #Tcells, #Bcells, and #macrophages Read our latest review on the role of artesunate online: https://t.co/bItUGxD72S
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Mashup Score: 2Nicotinamide Antagonizes Lipopolysaccharide-Induced Hypoxic Cell Signals in Human Macrophages - 10 month(s) ago
Key Points. LPS increased phagocytosis, NADPH oxidase activity, hypoxic signals, and inflammation.NAM increased NAD and posttranslational modifications to inhib
Categories: Allergy-Immunology, Latest HeadlinesTweet-
#Nicotinamide inhibits LPS-induced hypoxic cell signals and #metabolism in human monocyte-derived #macrophages | from Collen S. Curran & colleagues @NIHCritCare | #ReadTheJI #immunology #FreetoRead #AuthorChoice 👉 https://t.co/prhaQFagyO https://t.co/MieS8Bi49X
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Mashup Score: 4SARS-CoV-2 ORF8 Mediates Signals in Macrophages and Monocytes through MyD88 Independently of the IL-17 Receptor - 10 month(s) ago
Key Points. SARS-CoV-2 ORF8 but not IL-17 upregulates cytokines in monocytes/macrophages.Monocytes and macrophages infected with SARS-CoV-2 do not express IL-17
Categories: Allergy-Immunology, Latest HeadlinesTweet-
#JI_TopRead from @nic_ponde and #JI_editor @slg1717 @PittTweet : ORF8 transduces inflammatory signaling in #monocytes & #macrophages via #MyD88 independently of the #IL17R #ReadTheJI #immunology #cytokines 👉 https://t.co/SmEzkukMlT https://t.co/AWYv7c83Fn
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Mashup Score: 1Ubiquitin Ligases Siah1a/2 Control Alveolar Macrophage Functions to Limit Carcinogen-Induced Lung Adenocarcinoma - 10 month(s) ago
The ubiquitin ligases Siah1a/2 control proinflammatory signaling, differentiation, and profibrotic phenotypes of alveolar macrophages to suppress lung carcinogenesis.
Categories: Hem/Onc News and Journals, Latest HeadlinesTweet-
Scortegagna et al. identify the ubiquitin ligases Siah1a/2 as gatekeepers of #lungcancer development by controlling proinflammatory signaling, differentiation, and profibrotic phenotypes of alveolar #macrophages. https://t.co/iJrdM9PaY2 @ZeevRonai @NCIEytanRuppin @SBPCancerCenter https://t.co/C2v0fl4JaY
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Mashup Score: 6Please wait whilst we redirect you - 1 year(s) ago
About ScienceDirectRemote accessShopping cartAdvertiseContact and supportTerms and conditionsPrivacy policyWe use cookies to help provide and enhance our service and tailor content and ads. By continuing you agree to the use of cookies.Copyright © 2023 Elsevier B.V. or its licensors or contributors. ScienceDirect® is a registered trademark of Elsevier B.V.ScienceDirect® is a registered trademark…
Source: www.sciencedirect.comCategories: Hem/Oncs, Latest HeadlinesTweet-
RT @Sri_Baqri: #Macrophages in #cancer - beautifully reviewed by @LeilaAkkari1 @djkloosterman https://t.co/FZoNi7hnFa #tumorimmunology @Cel…
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Mashup Score: 0Traumatic Brain Injury Interferes with Immune System Cells’ Recycling Process in Brain Cells - 1 year(s) ago
In a new study published in the January issue of Autophagy, they found that after traumatic brain injury, the brain’s immune system cells’ internal recyclin
Source: www.newswise.comCategories: Healthcare Professionals, Latest HeadlinesTweet-
Traumatic #BrainInjury Interferes with Immune System Cells’ Recycling Process in Brain Cells https://t.co/3L73mTLXl4 #TBI #neuroinflammation #neurdegeneration #cognition Inhibition of #autophagy in #microglia and #macrophages exacerbates innate immune responses and worsens… https://t.co/bFUHZbaRsg https://t.co/6AQvk6Y6Rz
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Mashup Score: 5Nature Reviews Cancer - Volume 23 Issue 4, April 2023 - 1 year(s) ago
Macrophage Diptych, inspired by the Perspective on p238.
Source: NatureCategories: Hem/Onc News and Journals, Latest HeadlinesTweet-
Our April issue is out NOW! It's an #immunity heavy issue, with articles focused on #macrophages in cancer, immune stimulating #CAFs, #tumourmyeloidcells and the #immunoregulatory functions of cancer cells. CHECK 👏IT👏OUT👏! https://t.co/2PqtcowhYH @NatResCancer https://t.co/jBdadnWBwI
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Mashup Score: 0T helper 2 cells control monocyte to tissue-resident macrophage differentiation during nematode infection of the pleural cavity - 1 year(s) ago
Current understanding is that, in the steady state, macrophages acquire tissue residency in response to local tissue signals. Finlay et al. show that during nematode infection of the pleural cavity, Th2 cells can accelerate the progression of monocytes into tissue-resident macrophages, which become anti-inflammatory and support nematode killing.
Source: ImmunityCategories: Infectious Disease, Latest HeadlinesTweet-
📑 If you haven't read it yet, bookmark this @ImmunityCP study led by @Conorisco at @ProfJudiAllen's lab! And get ready to learn everything you wanted to know about what goes on with #Th2 cells and #macrophages during tissue #nematode infection. 🪱 📖 https://t.co/PJpFMOUCbw https://t.co/VqgEO2SEED
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Mashup Score: 1Enzyme-regulating macrophages found in both humans and mice open the door to translating findings in mice into human therapies. - 1 year(s) ago
Researchers at Nagoya University in Japan have identified the role of an enzyme responsible for the cross-linking reaction that activates macrophage, which is important in the development of kidney fibrosis. These enzymes induce a common activation mechanism in both rodent and human macrophages, which will increase the relevance of rodent models to the human disease. The results are expected to…
Source: EurekAlert!Categories: General Medicine News, Latest HeadlinesTweet-
#Enzyme-regulating #macrophages found in both #humans and #mice open the door to translating findings in mice into human therapies @NagoyaUniv #inflammatorydisorders #drugresearch https://t.co/8zQ0VpSxlQ
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Studying mice and data from #COVID19 patients, scientists discover a molecular pathway involving #macrophages that worsens #sepsis—and suggest that the cytokine TGF-beta could present a target in this deadly condition. @scisignal https://t.co/e50HjtCvlY https://t.co/HuLaexDFpP