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Mashup Score: 11Metabolism in type 2 immune responses - 1 year(s) ago
Key elements of type 2 immune responses are integrated within tissues and are part of tissue homeostasis and repair. Pearce and colleagues review how metabolic regulation relates to type 2 immunity, discussing both specifics of metabolism and metabolic adaptation within type 2 immune cells and how type 2 immune cells are integrated more broadly into the metabolism of the organism as a whole.
Source: ImmunityCategories: Allergy-Immunology, Latest HeadlinesTweet
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Mashup Score: 11The orphan receptor Nur77 binds cytoplasmic LPS to activate the non-canonical NLRP3 inflammasome - 1 year(s) ago
Cytosolic LPS triggers non-canonical NLRP3 inflammasome activation, but how the NLRP3 inflammasome is ignited is still vague. In this issue of Immunity, Zhu et al. show that Nur77 detects both the dsDNA released from the mitochondria and the intracellular LPS to activate the NLRP3 inflammasome.
Source: ImmunityCategories: Allergy-Immunology, Latest HeadlinesTweet
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Mashup Score: 1STING activation in platelets aggravates septic thrombosis by enhancing platelet activation and granule secretion - 1 year(s) ago
Identifying mechanisms of platelet activation would improve our limited understanding of septic-induced coagulopathy. Yang et al. reveal that the DNA sensor, STING, in platelets promotes their granule secretion, which drives subsequent septic thrombosis. Furthermore, this work identifies a STING-STXBP2 interaction as a potential target for sepsis interventions.
Source: ImmunityCategories: Infectious Disease, Latest HeadlinesTweet
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Mashup Score: 0T helper 2 cells control monocyte to tissue-resident macrophage differentiation during nematode infection of the pleural cavity - 1 year(s) ago
Current understanding is that, in the steady state, macrophages acquire tissue residency in response to local tissue signals. Finlay et al. show that during nematode infection of the pleural cavity, Th2 cells can accelerate the progression of monocytes into tissue-resident macrophages, which become anti-inflammatory and support nematode killing.
Source: ImmunityCategories: Infectious Disease, Latest HeadlinesTweet
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Mashup Score: 65
Our understanding of T cell responses in COVID-19 and vaccination is incomplete. Gao et al. examine SARS-CoV-2-specific T cell responses to infection and vaccination, revealing disparate kinetics between CD4+ and CD8+ T cells. Furthermore, compared to vaccination alone, circulating CD8+ T cells are attenuated during infection and in subsequent vaccination.
Source: ImmunityCategories: Allergy-Immunology, Latest HeadlinesTweet
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Mashup Score: 0Defining the landscape of human epidermal mononuclear phagocytes - 1 year(s) ago
The stratified squamous epithelium (SSE) forms the epidermis of skin (e.g., trunk skin, foreskin, and labia) and the epithelium of type II mucosal tissues (e.g., vagina, ectocervix, and anal canal). Langerhans cells (LCs) were long thought to be the sole mononuclear phagocyte (MNP) residing in these tissues. However, two decades ago, other MNP populations appearing as dendritic cells (DCs) were…
Source: ImmunityCategories: Allergy-Immunology, Latest HeadlinesTweet
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Mashup Score: 0Persistence is key: Refining immunotherapy response prediction - 1 year(s) ago
Tumor mutation burden (TMB) is a proven, but imperfect, immune checkpoint blockade (ICB) response-predictor. Recently in Nature Medicine, Niknafs et al. demonstrate that persistent mutation burden, a subset of TMB, is an improved metric to predict patient ICB therapy outcome.
Source: ImmunityCategories: Allergy-Immunology, Latest HeadlinesTweet
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Mashup Score: 0Response to identifying the epidermal dendritic cell landscape - 1 year(s) ago
In their letter to Immunity,1 Bertram et al. argue that a subset of Langerhans cells (LCs), LC2, which we recently defined,2 shares the same surface markers with epidermal CD11c+ dendritic cells (DCs) and is actually classical DC2 (cDC2). The authors summarized the previously reported markers of epidermal CD11c+ DC subsets and found that they were highly consistent with those of LC2.2…
Source: ImmunityCategories: Allergy-Immunology, Latest HeadlinesTweet
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Mashup Score: 1ARMH3-mediated recruitment of PI4KB directs Golgi-to-endosome trafficking and activation of the antiviral effector STING - 1 year(s) ago
Activation of the cGAS-STING pathway by cytoplasmic DNA involves cGAMP-induced STING translocation from the ER to the Golgi. Fang et al. show that Armadillo-like helical domain-containing protein 3 (ARMH3) interacts with STING at the Golgi and recruits PI4KB to synthesize PI4P, which directs STING Golgi-to-endosome trafficking and constructs the lipid environment required for STING activation via…
Source: ImmunityCategories: Allergy-Immunology, Latest HeadlinesTweet
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Mashup Score: 2Toward a general model of CD4+ T cell subset specification and memory cell formation - 1 year(s) ago
Our understanding of CD4+ T cell biology currently suffers from a divergence between helper subset differentiation and memory formation. In this perspective, Jenkins and colleagues propose an integrative model broadly incorporating the concepts of Th1/Th2 differentiation, central and effector memory formation, and cellular and humoral immunity.
Source: ImmunityCategories: Allergy-Immunology, Latest HeadlinesTweet
RT @LabWaggoner: REVIEW: Metabolic regulation relates to type 2 immunity @ImmunityCP PearceLab https://t.co/2Q5Cf5mYR6