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    Inflammation and infection in plasma cell disorders: how pathogens shape the fate of patients - 2 year(s) ago

    The role of infection and chronic inflammation in plasma cell disorders (PCD) has been well-described. Despite not being a diagnostic criterion, infection is a common complication of most PCD and represents a significant cause of morbidity and mortality in this population. As immune-based therapeutic agents are being increasingly used in multiple myeloma, it is important to recognize their impact…

    Source: www.nature.com
    Categories: Hem/Onc News and Journals, Latest Headlines
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      LeukemiaJnl

      Inflammation and infection in plasma cell disorders: how pathogens shape the fate of patients Read for free using #SharedIt: https://t.co/7AtM9BG26C #Adaptiveimmunity #Innateimmunity #Myeloma #Preventivemedicine https://t.co/izfbEjiUHu

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    Modulation of SF3B1 in the pre-mRNA spliceosome induces a RIG-I-dependent type I IFN response - 2 year(s) ago

    Nucleic acid–sensing pathways play critical roles in innate immune activation through the production of type I interferon (IFN-I) and proinflammatory cytokines. These factors are required for effective antitumor immune responses. Pharmacological modulators of the pre-mRNA spliceosome splicing factor 3b subunit 1 (SF3B1) are under clinical investigation as cancer cytotoxic agents. However,…

    Source: Journal of Biological Chemistry
    Categories: Allergy-Immunology, Latest Headlines
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      ImmunologyNews

      Chang et al.'s study suggests that spliceosome modulation may not only induce direct cancer cell cytotoxicity but also initiate an innate immune response via activation of RNA-sensing pathways — @pfizer #mRNA #innateimmunity https://t.co/mmwfPW0OCU

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    Recognition of acrolein-specific epitopes by B cell receptors triggers an innate immune response - 3 year(s) ago

    Natural antibodies, predominantly immunoglobulin M (IgM), play an important role in the defense against pathogens and in maintaining homeostasis against oxidized molecules known as oxidation-specific epitopes, such as those contained in oxidized low-density lipoproteins. However, owing to the complexity of the oxidized products, very few individual epitopes have been characterized in detail. In…

    Source: Journal of Biological Chemistry
    Categories: Allergy-Immunology, Latest Headlines
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      ImmunologyNews

      Endo et al. present results that show the presence of innate B cells expressing the acrolein-specific BCR, and suggest that acrolein may play a role as a trigger of the innate immune response. – #InnateImmunity #Immunology #Acrolein https://t.co/6eDeQZQ4uS @UTokyo_News_en

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    Innate Immunity: Mechanisms and Modulation | EK39 - 3 year(s) ago

    The innate immune system is the first line of response to pathogens and tissue injury. Specialized cells have evolved mechanisms to detect…

    Source: virtual.keystonesymposia.org
    Categories: Allergy-Immunology, Latest Headlines
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      TrendsImmuno

      Chat with Trends in Immunology editor Catarina Sacristan for @KeystoneSymp virtual #eSymposia, #InnateImmunity: Mechanisms and Modulation, to discover emerging research on #NKCells, #Macrophage, #Neutrophils and more. https://t.co/4MP4fXCddq #VKSInnateImmunity21 https://t.co/H6I8NhUe41