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Mashup Score: 0Loss of Endothelial TRPC1 Induces Aortic Hypercontractility and Hypertension | Circulation Research - 1 day(s) ago
BACKGROUND: The increasing prevalence of obesity-related cardiovascular diseases demands a better understanding of the contribution of different cell types to vascular function for developing new treatment strategies. Previous studies have established a fundamental role of TRPC1 (transient receptor potential channel canonical family member 1) in blood vessels. However, little is known about its functional roles within different cell types. METHODS: We generated endothelial-specific TRPC1-deficient and knockin mice and analyzed their changes in vascular function under physiological and pathologically obese state. Wire myography, Ca2+ image, blood pressure measurements, RNA-sequencing analysis, liquid chromatography–mass spectrometry, immunoblotting, ELISA, luciferase reporter assay, and morphometric assessments were performed to unravel phenotype and molecular changes in response to the absence or presence of endothelial TRPC1. RESULTS: Loss of endothelial TRPC1 reduced endothelial-depe
Source: www.ahajournals.orgCategories: General Medicine News, CardiologistsTweet
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Mashup Score: 0SMC Abca1 and Abcg1 Deficiency Enhances Urinary Bladder Distension but Not Atherosclerosis | Circulation Research - 3 day(s) ago
BACKGROUND: Smooth muscle cells (SMCs) regulate blood flow distribution via vasoconstriction mediated by α-ARs (α-adrenergic receptors). Plasma membrane cholesterol accumulation affects α1-AR signaling and promotes loss of SMC contractile markers in vitro. ABCA1 and ABCG1 (ATP-binding cassette transporter A1 and G1) mediate cholesterol efflux to HDL (high-density lipoprotein). ABCA1/ABCG1 show high expression in medial and low expression in intimal SMCs of atherosclerotic plaques. The role of ABCA1 and ABCG1 in SMC-mediated vasoconstriction and atherogenesis remains poorly understood. METHODS: We generated mice with SMC-specific Abca1/Abcg1 deficiency on the low-density lipoprotein receptor–deficient (Ldlr−/−) background by crossbreeding Abca1fl/flAbcg1fl/flLdlr−/− mice with Myh11CreERT2 transgenic mice. To induce SMC cholesterol accumulation and atherogenesis, we fed Myh11CreERT2Abca1fl/flAbcg1fl/flLdlr−/−, Myh11CreERT2Abca1fl/flLdlr−/−, Myh11CreERT2Abcg1fl/flLdlr−/−, and Myh11CreERT2
Source: www.ahajournals.orgCategories: General Medicine News, CardiologistsTweet-
Halmos et al show that the deficiency of cholesterol transporters #Abca1 & #Abcg1 in #SMCs enhances #vasoconstriction & urinary #bladder distension but does not affect lesion area in #atherosclerosis. Learn more at https://t.co/Y3jSQ92xz0 @SluimerJudithHelle @hfj22 https://t.co/KH6By9jHkA
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Mashup Score: 0Call for Submissions - 4 day(s) ago
Circulation Research welcomes the submission of Research Letters to accompany a Compendium on Environmental Impacts on Cardiovascular Health. Submissions should include timely observational, clinical, mechanistic, translational, basic, toxicological, and regulatory science related to advancing the understanding of the intersection of environment and cardiovascular disease and risk. Potential topics relevant to the compendium include the impact of air pollutants, noise and light pollution, green space,
Source: www.ahajournals.orgCategories: General Medicine News, Cardiology News and JournTweet-
Call for Submissions - Environmental Impacts on Cardiovascular Health. @circres welcomes the submission of Research Letters as part of a Compendium on Environmental Impacts on CV Health. Deadline for submission: Feb 9, 2024. Click link for Details: https://t.co/s2kCs8uddL https://t.co/fc6HqZRgd5
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Mashup Score: 0Deciphering Platelets: Are They Cells or an Evolved Form of Extracellular Vesicles? | Circulation Research - 17 day(s) ago
Platelets are abundant in blood, where they maintain the integrity of the vasculature. Megakaryocytes, the cells responsible for platelet genesis, produce membrane protrusions from which as many as 5000 anucleate platelets can be released into the bloodstream. Platelets lack genomic DNA but contain different molecules, such as RNA, as well as organelles transmitted from the parent megakaryocyte. There is no consensus in the scientific community on whether platelets are cells or not: for example, they are sometimes called cells, small cells, anucleated cells, cell fragments, or megakaryocyte fragments. Extracellular vesicles are particles delimited by a lipid bilayer that are released from cells but cannot replicate on their own. Like platelets, extracellular vesicles lack a nucleus and carry components from their donor cell. Herein, we will explore various viewpoints suggesting that platelets may be cells, albeit not conventional cells, or may be a previously unrecognized type of extra
Source: www.ahajournals.orgCategories: General Medicine News, CardiologistsTweet-
Check out the latest review in the Feb 14th issue of @CircRes by Boilard & colleagues "Deciphering #Platelets: Are They Cells or an Evolved Form of #ExtracellularVesicles?" at https://t.co/aMIjsAg1tp @boilard_eric @theclotthickens @EditBuzas @DSchnekenB https://t.co/vyUKQmDgSB
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Mashup Score: 5Call for Submissions - 27 day(s) ago
Circulation Research welcomes the submission of Research Letters to accompany a Compendium on Environmental Impacts on Cardiovascular Health. Submissions should include timely observational, clinical, mechanistic, translational, basic, toxicological, and regulatory science related to advancing the understanding of the intersection of environment and cardiovascular disease and risk. Potential topics relevant to the compendium include the impact of air pollutants, noise and light pollution, green space,
Source: www.ahajournals.orgCategories: General Medicine News, Cardiology News and JournTweet-
Call for Submissions - Environmental Impacts on Cardiovascular Health. @circres welcomes the submission of Research Letters as part of a Compendium on Environmental Impacts on CV Health. Deadline for submission: Feb 9, 2024. Click link for Details: https://t.co/s2kCs8uddL https://t.co/fc6HqZRgd5
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Mashup Score: 3Arterial NALCN Knockdown Ameliorates Mineralocorticoid-Induced Hypertension and Arterial Overcontractility | Circulation Research - 28 day(s) ago
Meet the First Author, see p 257 In hyperaldosteronism-related hypertension, increased blood volume has been regarded as a primary contributor. However, increases in arterial contractility and total peripheral resistance are also important. 1 In addition, nonrenal mechanisms (ie, direct regulation of the cardiovascular ion channels) of mineralocorticoid-induced hypertension and heart failure have been suggested. 2 Total peripheral resistance is determined by contractile tones of arteries, which are under
Source: www.ahajournals.orgCategories: General Medicine News, CardiologistsTweet-
Lee & colleagues found that the sodium leak channel (#NALCN) which is known for its role in neuronal excitability is involved in mineralcorticoid-induced #hypertension in the #CV system. Learn more at https://t.co/iBmxSW47iu https://t.co/sZATGrW1pt
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Mashup Score: 2ABE-Mediated Cardiac Gene Silencing via Single AAVs Requires DNA Accessibility | Circulation Research - 29 day(s) ago
View all available purchase options and get full access to this article. File (circres-2024-325611-s01.pdf) Major Resources Table File (circres-2024-325611-s02.pdf) Reichart D, Newby GA, Wakimoto H, Lun M, Gorham JM, Curran JJ, Raguram A, DeLaughter DM, Conner DA, Marsiglia JDC, et al. Efficient in vivo genome editing prevents hypertrophic cardiomyopathy in mice. Nat Med. 2023;29:412–421. doi: 10.1038/s41591-022-02190-7 Lebek S, Chemello F, Caravia XM, Tan W, Li H, Chen K, Xu L, Liu N, Bassel-Duby R,
Source: www.ahajournals.orgCategories: General Medicine News, CardiologistsTweet-
Liu & colleagues demonstrated adenine base editor (#ABE) mediated cardiac gene silencing via a single #AAV. Learn about overcoming some of the challenges of cardiac base editing at https://t.co/ZAFEgSjxWz @PKU1898 https://t.co/VoOKbyNTRL
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Mashup Score: 2
BACKGROUND: Metabolic syndrome heightens cardiovascular disease risk primarily through increased arterial stiffness. We previously demonstrated the involvement of YAP (Yes-associated protein) in high-fat/high-sucrose diet (HFHSD)–induced arterial stiffness via modulation of PPM1B (protein phosphatase Mg2+/Mn2+–dependent 1B)-lysine 63(K63) deubiquitination. In this study, we aimed to elucidate the role and mechanisms underlying PPM1B deubiquitination in HFHSD-induced arterial stiffness. METHODS: Enzymes governing PPM1B deubiquitination were identified through small interfering RNA (siRNA) screening and mass spectrometry. Glutathione S-transferase pull-down, coimmunoprecipitation, protein purification, and immunofluorescence were used to explore the mechanism underlying PPM1B deubiquitination. Doppler ultrasound was used to evaluate HFHSD-induced arterial stiffness in mice, and telemetry was used to record pulsatile (systolic and diastolic) blood pressure. RESULTS: Smooth muscle cell–spe
Source: www.ahajournals.orgCategories: General Medicine News, CardiologistsTweet-
Liu & colleagues found #PPM1B has a protective role in #HFHSD-induced #arterial stiffness, depending on K63-linked #polyubiquitination at the K326 site. Learn how #deubiquitination promotes arterial stiffness at https://t.co/MCWBB7i4gV https://t.co/b9E7sKHnRz
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Mashup Score: 0Author Hub | AHA/ASA Journals - 1 month(s) ago
Rigorous, dependable research has always been at the core of the American Heart Association (AHA) mission to be a relentless force for a world of longer, healthier lives and vision of advancing health and hope for everyone, everywhere. Offering 14 scientific research journals that cover the breadth of cardiovascular and cerebrovascular disease, the AHA serves the specific needs of investigators and clinicians in subspecialties by providing online access to full-text articles for Professional, Early
Source: www.ahajournals.orgCategories: General Medicine News, CardiologistsTweet-
Connect with the #AHAJournals at our new Author Hub! #ESCCongress Go to https://t.co/Uaz0XAfF3H to explore today
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Mashup Score: 0Author Hub | AHA/ASA Journals - 1 month(s) ago
Rigorous, dependable research has always been at the core of the American Heart Association (AHA) mission to be a relentless force for a world of longer, healthier lives and vision of advancing health and hope for everyone, everywhere. Offering 14 scientific research journals that cover the breadth of cardiovascular and cerebrovascular disease, the AHA serves the specific needs of investigators and clinicians in subspecialties by providing online access to full-text articles for Professional, Early
Source: www.ahajournals.orgCategories: General Medicine News, CardiologistsTweet-
Connect with the #AHAJournals at our new Author Hub! #ESCCongress Go to https://t.co/Uaz0XAfF3H to explore today
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Zhu & colleagues found that loss of endothelial #TRPC1 aggravates vascular contraction and up-regulates blood pressure. Learn more about strategies to improve vascular function at https://t.co/MRi1m3QpAV https://t.co/zBwhcj4zyE