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BACKGROUND: Observed patient survival after cardiothoracic interventions should ideally be placed in the context of matched-general-population survival. This study outlines several methodologies of matching general population mortality to the study sample, subsequently calculating cumulative matched-general-population survival, highlighting their respective advantages, disadvantages, and limitations. METHODS: A multicenter data set containing survival data after the Ross procedure was used for methodological illustration. General population mortality was extracted from country-specific life tables in the Human Mortality Database. The matched-general-population mortality, also known as background mortality, was obtained by matching general population mortality to the study sample using different matching strategies, iteratively considering median/individual age and median/individual calendar year, besides country and sex. The corresponding cumulative matched-general-population survival
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BACKGROUND: Few population-based studies have assessed sex differences in stroke recurrence. In addition, contributors to sex differences in recurrence and poststroke mortality, including social factors, are unclear. We investigated sex differences in these outcomes and the contribution of social, clinical, and behavioral factors to the sex differences. METHODS: First-ever ischemic stroke cases identified from 2008 to 2019 from the population-based Brain Attack Surveillance in Corpus Christi Project in Texas were included and followed for recurrence and all-cause mortality through 2020. Sex differences in outcomes with and without adjustment for potential confounding factors, including social, behavioral, and clinical factors, were examined using Cox proportional hazard models. Factors that changed the log hazard ratio (HR) for sex by at least 10% after adjustment were identified as confounders/contributors. Final models were adjusted for all identified confounders. RESULTS: Of 2326 pa
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Associations of Social, Behavioral, and Clinical Factors With Sex Differences in Stroke Recurrence and Poststroke Mortality #AHAJournals https://t.co/VGJGiMpEuN https://t.co/qfIgKuA7QC
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Mashup Score: 0Left Ventricular Assist Device Therapy in Cold and Dry Patients | Circulation: Heart Failure - 4 hour(s) ago
BACKGROUND: Patients with end-stage heart failure and low pulmonary capillary wedge pressure are referred to as cold and dry and represent an understudied minority in whom the benefit of left ventricular assist device (LVAD) therapy is unclear. METHODS: Adults receiving LVADs between 2006 and 2017 in the Interagency Registry for Mechanically Assisted Circulatory Support database were classified as cold and wet (pulmonary capillary wedge pressure >15 mm Hg) and cold and dry (pulmonary capillary wedge pressure ≤15 mm Hg) based on pre-LVAD hemodynamics obtained via right heart catheterization. The primary outcome was 1-year survival. Secondary outcomes were rehospitalizations, change in 6-minute walk test distance, change in Kansas City Cardiomyopathy Questionnaire, and change in EuroQol questionnaire scores 1 year after LVAD. RESULTS: Our study included 10 310 patients with complete clinical, echocardiographic, and functional capacity profiles. The median follow-up was 364 days (interqua
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Heart Failure patients with "cold and dry" profile derive similar benefit from LVAD therapy as "cold and wet" patients @DimitriVarrias @MAlvarezVillela @AmritaBalgobind @alhuarrat #AHAJournals https://t.co/7D4hQkeA7k https://t.co/NJLABBQy16
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Mashup Score: 0Aerobic Capacity of Adults With Fontan Palliation: Disease-Specific Reference Values and Relationship to Outcomes | Circulation: Heart Failure - 4 hour(s) ago
BACKGROUND: Patients with Fontan palliation have reduced aerobic capacity because of impaired cardiac, pulmonary, and skeletal muscle function. However, the assessment of aerobic capacity in this population still relies on comparisons with people without cardiovascular disease rather than comparison with the expected aerobic capacity of other Fontan patients. The purpose of this study was to determine the expected aerobic capacity of adults with Fontan palliation. METHODS: Adults with Fontan palliation who underwent a cardiopulmonary exercise test at Mayo Clinic (2003–2023) were stratified into quartiles based on the predicted peak oxygen consumption (VO2). We assessed the correlates of predicted peak VO2 and the relationship between predicted peak VO2 quartiles and cardiovascular outcomes (death/transplant). RESULTS: Of 323 patients (age, 29±9 years; 177 [55%] men), the median peak VO2 was 19.1 (15.2–23.9) mL/kg per minute, and this corresponds to a predicted peak VO2 of 51% (range, 1
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Impaired aerobic capacity was almost universal in this cohort of adults with Fontan palliation, and was associated with clinical outcomes @MAYOACHD @bborlaugmd @ahmedelsaid_95 #AHAJournals https://t.co/Jot4nVCfn0 https://t.co/ZF8EONkyfT
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View all available purchase options and get full access to this article. File (circcvqo-2024-011544-s01.pdf) Figures S1 and S2 File (circcvqo-2024-011544-s02.pdf) Request permissions for this article. Department of Internal Medicine, Mayo Clinic, Rochester, MN (C.L.C.). Department of Internal Medicine, Division of Cardiology, University of Texas Southwestern Medical Center, Dallas (S.G., Nimesh Patel, M.K., M.S.S.). Department of Internal Medicine, Division of Palliative Care, UT Southwestern Medical
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Development of an Innovative Decision-Aid to Better Align Patients' Implantable Cardioverter Defibrillator Shock Status with Goals of Care @pristinethinpen @melsulistio @nsp243 @kelleynewcomer @Parkland @utswheart @utswedu @MayoMN_IMRES #AHAJournals https://t.co/lrLTZfkdC5 https://t.co/zJWps6FTPe
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Inhibition of the renin‐angiotensin system (RAS) has been shown to be associated with concentric thickening of the renal arteries and arterioles 1 due to expansion of immature matrix‐producing renin cells and inward accumulation of abnormal smooth muscle cells. With emerging RNA therapies blocking RAS at the level of angiotensinogen, such as liver‐targeted, N ‐acetylgalactosamine–conjugated small interfering RNA (siRNA) and antisense oligonucleotides, the question is to what degree angiotensinogen
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Kidney arteriolar response to angiotensinogen siRNA is identical to that of other renin‐angiotensin system blockers. #AHAJournals #ResearchLetter https://t.co/i2fWb3deeU https://t.co/QbzSlP0trD
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Mashup Score: 1
View all available purchase options and get full access to this article. Request permissions for this article. For Sources of Funding and Disclosures, see page XXX. Correspondence to: Kristoffer Berg-Hansen, MD, PhD, Department of Cardiology, Aarhus University Hospital, Palle Juul-Jensens Blvd 99, DK-8200 Aarhus, Denmark. Email: [email protected] If you have the appropriate software installed, you can download article citation data to the citation manager of your choice. Select your manager software from
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Neurohormonal and Renal Effects of 14-Day Oral Ketone Ester Treatment in Patients with Heart Failure with Reduced Ejection Fraction @svartmads @K_Hylleberg @GNigopan @NikolajRittig @krisberghansen #AHAJournals https://t.co/kytLmrK3Ko https://t.co/JPC6v7MiDm
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Mashup Score: 3Medicare Coverage and Patient Out-of-Pocket Costs for Mavacamten | Circulation: Cardiovascular Quality and Outcomes - 4 hour(s) ago
View all available purchase options and get full access to this article. File (circcvqo-2024-011331-s01.pdf) Request permissions for this article. Department of Internal Medicine, Saint Vincent Hospital, Worcester, MA (K.B.). Division of Cardiology, Department of Medicine, Oregon Health and Science University, Portland (C.V.C., A.M.). Division of Cardiology, Department of Medicine, Oregon Health and Science University, Portland (C.V.C., A.M.). Division of Cardiovascular Medicine, Department of Internal
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Mavacamten is covered by 25% Medicare plans, but 94% plans mandate prior auths and most have high out-of-pocket costs @KannuBansalMD @SaurabhSDani @LaheyCardiology @YaleHFdoc @MasriAhmadMD @ralphadelta #AHAJournals https://t.co/aDtzEvkO2f https://t.co/Qzw3uTSRUZ
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Mashup Score: 0Pulseless Paradoxus: Pulsus Paradoxus of the 21st Century | Circulation: Heart Failure - 4 hour(s) ago
View all available purchase options and get full access to this article. Request permissions for this article. Division of Cardiology, Department of Internal Medicine, University of Rochester Medical Center, NY (A.J.). For Sources of Funding and Disclosures, see page XXX. C orrespondence to: Faris G. Araj, MD, Division of Cardiology, Department of Internal Medicine, University of Texas Southwestern Medical Center, Professional Office Bldg 2, Ste 600, 5939 Harry Hines Blvd, Dallas, TX 75390. Email [email
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Pulseless paradoxus is a novel clinical sign of cardiac tamponade under continuous-flow conditions @beaini_hadi @UTSWHeart @UTSWMedCenter #AHAJournals https://t.co/lK6AslzTjC https://t.co/rqN8zjMq7z
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Mashup Score: 2Pseudo-Severe Mitral Stenosis From Obesity-Related HFpEF and Atrial Myopathy | Circulation: Heart Failure - 4 hour(s) ago
View all available purchase options and get full access to this article. Obokata M, Reddy YNV, Pislaru SV, Melenovsky V, Borlaug BA. Evidence supporting the existence of a distinct obese phenotype of heart failure with preserved ejection fraction. Circulation. 2017;:6–19. doi: 10.1161/CIRCULATIONAHA.116.026807 Reddy YNV, Obokata M, Verbrugge FH, Lin G, Borlaug BA. Atrial dysfunction in patients with heart failure with preserved ejection fraction and atrial fibrillation. J Am Coll Cardiol. 2020;:1051–1064.
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HFpEF and atrial myopathy can independently increase mitral gradients and overestimate stenosis severity – a diagnostic dilemma resolved by exercise cath @mayoclinicCV @yreddyhf @bborlaugmd @jennyjlcao #AHAJournals https://t.co/aunpkS1cGZ https://t.co/aoFPkd2CBM
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We outline robust approaches to calculate matched-general-population survival, emphasizing patient-level data via a Shiny App @JJMTakkenberg @ErasmusMC #AHAJournals https://t.co/iZ3Aup4igX