• Mashup Score: 0
    SARS-CoV-2 reservoir in post-acute sequelae of COVID-19 (PASC) - 1 year(s) ago

    Nature Immunology – Proal and colleagues review the evidence for long-term persistence of coronavirus SARS-CoV-2 in tissues of infected individuals and discuss how this viral reservoir may…

    Source: www.nature.com
    Categories: Infectious Disease, Latest Headlines
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      📖 Scientists with Dr. Amy Proal (@microbeminded2) at @polybioRF #review studies that have identified 😷 #SARSCoV2 RNA/protein or #immune responses indicative of a SARS-CoV-2 reservoir in post-acute sequelae of #COVID19 samples. @NatImmunol | https://t.co/6ZUqyXoWKl https://t.co/8EWnttWsGt

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    Antiviral CD8+ T-cell immune responses are impaired by cigarette smoke and in COPD - 1 year(s) ago

    Cigarette smoke impairs virus-induced upregulation of the MHC class I antigen presentation machinery resulting in reduced activation of antiviral CD8+ T-cells. This may reduce viral clearance and increase susceptibility to viral exacerbations in COPD. https://bit.ly/43o0p3D

    Source: erj.ersjournals.com
    Categories: Infectious Disease, Latest Headlines
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      Antiviral #immune responses are impaired by 🚭 cigarette smoke and in #COPD! Researchers at @HelmholtzMunich analyzed the effects of #cigarette smoke on cytokine- and virus-mediated induction of the immunoproteasome. 🔓 Learn more at @ERSpublications | https://t.co/Evetvqv2fb https://t.co/I3zDaTqYtT

  • Mashup Score: 2
    CD4+ T cells regulate sickness-induced anorexia and fat wasting during a chronic parasitic infection - 1 year(s) ago

    Redford et al. demonstrate that that CD4+ and CD8+ T cells have distinct contributions for the pathogenesis of fat and lean stores wasting, respectively, during a chronic parasitic infection. While fat wasting has no role in host defense, muscle wasting is important for disease tolerance and survival.

    Source: www.cell.com
    Categories: Infectious Disease, Latest Headlines
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      💡 Why do infections cause loss of fat and muscle stores? @SalkInstitute researchers including @SamRedford1 examined the role of the adaptive #immune response in adipose tissue wasting and cachexia during a chronic parasitic infection. 📘 @CellReports | https://t.co/81tm5ITU8a https://t.co/EWnJc7Rtev

  • Mashup Score: 5
    An immunostimulatory glycolipid that blocks SARS-CoV-2, RSV, and influenza infections in vivo - Nature Communications - 2 year(s) ago

    7DW8-5 is a glycolipid that binds CD1d and stimulates invariant natural killer T (iNKT) cells. Here the authors show that 7DW8-5, when administered intranasally, provides prophylactic anti-viral effects against influenza, RSV, and SARS-CoV-2 in mice or hamsters, and that this effect is mediated by iNKT cells and IFN-γ.

    Source: Nature
    Categories: Infectious Disease, Latest Headlines
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      🥼 Dr. Moriya Tsuji of @cuimc_id and collaborators evaluated a NK #Tcell-stimulatory agent for respiratory virus infections. A glycolipid, 7DW8-5, was reported to exploit the host innate #immune system to enable rapid control of viral infections. 📑 https://t.co/vvVdmWqPAo https://t.co/NmDMn8xZFf

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    ISHLT: The International Society for Heart & Lung Transplantation - ALFTX - 2 year(s) ago

    After an inspiring opening plenary, “Back to the Future of AMR,” co-chaired by Glen Westall, FRACP, PhD from Alfred Hospital in Melbourne, and Meghan Aversa, MD, from the University of Toronto, engaged attendees seeking an update about the current state of knowledge on the detection, pathogenesis, and treatment of antibody-mediated rejection (AMR). Jake Natalini, MD, MSCE, from NYU Langdon…

    Source: www.ishlt.org
    Categories: Cardiology News and Journals, Latest Headlines
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      The Lung team - @dralourdeschac1 and @RAKlingbeilDNP - spent Friday at #ISHLT2023 reviewing #immune checkpoints in #ThoracicTX, #perioperative fungal and bacterial infections, and new heights in tackling #CMV. https://t.co/s87Z7Ma5jD https://t.co/UBTbYGYJAF

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