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Mashup Score: 32The TRIM37 variant rs57141087 contributes to triple-negative breast cancer outcomes in Black women | EMBO reports - 10 day(s) ago
imageimageThe risk variant rs57141087 is predominant in Black women and modulates TRIM37 levels through enhancer-promoter interactions. TRIM37 overexpression in early stages promotes neoplastic transformations, accelerates tumorigenesis, and …
Source: www.embopress.orgCategories: General Medicine News, General HCPsTweet
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Mashup Score: 183What is a PhD? | EMBO reports - 14 day(s) ago
EMBO Press is an editorially independent publishing platform for the development of EMBO scientific publications.
Source: www.embopress.orgCategories: General Medicine News, NeurologyTweet-
RT @isciverse: What is a PhD? Open Access https://t.co/MIOg83X4zB #PhD #PhDlife #academics #AcademicChatter #AcademicTwitter #Postdocs #R…
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Mashup Score: 6Longitudinal autophagy profiling of the mammalian brain reveals sustained mitophagy throughout healthy aging | The EMBO Journal - 1 month(s) ago
imageimageAging diminishes autophagy in short-lived model organisms. This study uncouples macroautophagy and mitophagy in the aging mouse brain at the single-cell level in vivo by profiling two optical reporter models. Differences across brain …
Source: www.embopress.orgCategories: General Medicine News, NeurologyTweet-
“Longitudinal autophagy profiling of the mammalian brain reveals sustained mitophagy throughout healthy aging” by Anna Rappe et al. EMBO Journal https://t.co/S84fbhxiIz
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Mashup Score: 1Leishmania protein KMP-11 modulates cholesterol transport and membrane fluidity to facilitate host cell invasion | EMBO reports - 2 month(s) ago
imageimageThe Leismhania membrane protein KMP-11 facilitates parasite invasion into macrophages through cholesterol transport from the macrophage membrane to Leishmania and subsequent phase transition in the host cell membrane. KMP-11 transports …
Source: www.embopress.orgCategories: General Medicine News, Infectious DiseaseTweet-
🔎 Investigators explored the underlying lipid membrane modification during #pathogenic invasion and found that that a specific Leishmania donovani (LD) protein, KMP-11, formed oligomers that bridge LD and host #macrophage membranes. @emboreports | https://t.co/Nj0iJf9uI2 https://t.co/0bUE5N9GP4
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Mashup Score: 9Circadian rhythms of macrophages are altered by the acidic tumor microenvironment | EMBO reports - 2 month(s) ago
imageimageCircadian rhythms of macrophages are altered by conditions associated with the tumor microenvironment, including acidic pH. This may be responsible for the heterogeneity in circadian clock gene expression within the tumor-associated …
Source: www.embopress.orgCategories: General Medicine News, Hem/OncsTweet-
RT @Aiims1742: Circadian rhythms of macrophages are altered by the acidic tumor microenvironment https://t.co/wTHtCYFcg4 Nice preclinical s…
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Mashup Score: 12The TrkC-PTPσ complex governs synapse maturation and anxiogenic avoidance via synaptic protein phosphorylation | The EMBO Journal - 3 month(s) ago
imageimageInteraction between neurotrophin-3 (NT-3) receptor TrkC and phosphatase PTPσ creates an excitatory synaptic organizing complex. Analysis of a new knock-in (KI) mouse model with disrupted TrkC binding to PTPσ, but not to NT-3, reveals the …
Source: www.embopress.orgCategories: General Medicine News, NeurologyTweet-
“The TrkC-PTPσ complex governs synapse maturation and anxiogenic avoidance via synaptic protein phosphorylation” by Hideto Takahashi et al. EMBO Journal https://t.co/MYwNT7j4IC
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Mashup Score: 0PCPE-1, a brown adipose tissue-derived cytokine, promotes obesity-induced liver fibrosis | The EMBO Journal - 3 month(s) ago
imageimageThe systemic control of tissue fibrosis by metabolic organs remains poorly understood. This study identifies procollagen C-endopeptidase enhancer-1 (PCPE-1) as an adipokine released from brown adipose tissue (BAT) upon dietary obesity. …
Source: www.embopress.orgCategories: General Medicine News, EndocrinologyTweet-
https://t.co/ARIPhP4xjE
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Mashup Score: 16
The systemic regulation of metabolic dysfunction-associated liver disease remains poorly understood. In this issue, Hsiao et al (2024) identify PCPE-1 as a brown-adipose tissue-derived mediator of …
Source: www.embopress.orgCategories: General Medicine News, EndocrinologyTweet-
Our editorial just out today in @embojournal on recent publication by @IppeiShimizuJPN providing evidence for a BATokine that promotes #Liver fibrosis in #obesity . @RePereira https://t.co/P7sDWje4tM
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Mashup Score: 50CRISPR-enabled point-of-care genotyping for APOL1 genetic risk assessment | EMBO Molecular Medicine - 4 month(s) ago
imageimageCRISPR-based diagnostics have the potential to increase the accessibility of genotyping for pathogenic variants due to its fast and user-friendly nature which enables on-site testing without elaborate machinery. The multiplexed CRISPR …
Source: www.embopress.orgCategories: General Medicine News, NephrologyTweet-
🚨Excited to share our work on a new CRISPR-based #pointofcare test to detect high-risk #APOL1 variants. Precise, quick and cheap test, without the need of any machine. Goal to bring #PrecisionMedicine to the bedside! Great collab with @KaminskiLab https://t.co/ccfIAp2aIn https://t.co/fgbShsxbm4
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Mashup Score: 2A critical role for HNF4α in polymicrobial sepsis-associated metabolic reprogramming and death | EMBO Molecular Medicine - 4 month(s) ago
imageimageBesides inflammation, metabolic dysregulation also contributes to sepsis lethality, offering therapeutic potential. This study shows that loss of hepatic HNF4α activity in sepsis disrupts PPARα-regulated lipid metabolism and the acute …
Source: www.embopress.orgCategories: General Medicine News, Infectious DiseaseTweet-
Céline Van Dender and team from @InflamResCen showed that hepatic HNF4α activity is decreased during #sepsis, causing PPARα downregulation, metabolic problems, and a disturbed IL6-mediated acute phase response. 🖨️ @EmboMolMed | 🔗 https://t.co/TBB0ouOax7 https://t.co/l4QrYLUmi8
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A potential biomarker, TRIM37, may explain the high rates of aggressive triple-negative breast #Cancer in Black women. This discovery could enhance diagnosis and prognosis, offering new hope for targeted treatments. @emboreports https://t.co/WdVGccBphK https://t.co/Ui6veevJZH