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Mashup Score: 9The growth factor EPIREGULIN promotes basal progenitor cell proliferation in the developing neocortex | The EMBO Journal - 2 month(s) ago
imageimageGrowth factors have been hypothesized to regulate the proliferative capacity of basal progenitor cells during neocortex development. This study reveals that expression of the growth factor EPIREGULIN, encoded by EREG, supports …
Source: www.embopress.orgCategories: General Medicine News, NeurologyTweet
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Mashup Score: 1AI-guided pipeline for protein–protein interaction drug discovery identifies a SARS-CoV-2 inhibitor | Molecular Systems Biology - 2 month(s) ago
imageimageA new pipeline for prioritizing protein-protein interactions (PPIs) for drug discovery, combines machine learning-based scoring of quantitative PPI data, protein complex structure prediction and virtual drug screening. A multi-adaptive …
Source: www.embopress.orgCategories: General Medicine News, Infectious DiseaseTweet
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Mashup Score: 1Exerkines and cardiometabolic benefits of exercise: from bench to clinic | EMBO Molecular Medicine - 3 month(s) ago
AbstractRegular exercise has both immediate and long-lasting benefits on cardiometabolic health, and has been recommended as a cornerstone of treatment in the management of diabetes and cardiovascu…
Source: www.embopress.orgCategories: General Medicine News, General HCPsTweet
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Mashup Score: 1Exerkines and cardiometabolic benefits of exercise: from bench to clinic | EMBO Molecular Medicine - 3 month(s) ago
AbstractRegular exercise has both immediate and long-lasting benefits on cardiometabolic health, and has been recommended as a cornerstone of treatment in the management of diabetes and cardiovascu…
Source: www.embopress.orgCategories: General Medicine News, General HCPsTweet
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Mashup Score: 22The DDHD2-STXBP1 interaction mediates long-term memory via generation of saturated free fatty acids | The EMBO Journal - 3 month(s) ago
imageimageThe mechanisms by which neuronal activity affects lipid metabolism in the brain remain little understood. This study identifies the phospholipase A1 isoform DDHD2 and the key synaptic protein STXBP1 as important regulators of lipid …
Source: www.embopress.orgCategories: General Medicine News, NeurologyTweet
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Mashup Score: 88Control of NAD+ homeostasis by autophagic flux modulates mitochondrial and cardiac function | The EMBO Journal - 4 month(s) ago
imageimageHow autophagy safeguards cardiac structure and function to prevent heart failure remains unclear. This genetic work links a novel connection between deficient autophagic flux in cardiomyocytes to reduced availability of the cellular …
Source: www.embopress.orgCategories: General Medicine News, EndocrinologyTweet-
Check out our recent paper in @embojournal describing novel connection between #autophagy, #NAD metabolism and #Mitochondria. Another layer of cellular nutrient sensing linking autophagy with regulation of the NAD degrading enzyme NNMT. @CharlesMBrenner https://t.co/U6JCrss5ZD https://t.co/JHo6S0yR9U
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Mashup Score: 13Defects in microvillus crosslinking sensitize to colitis and inflammatory bowel disease | EMBO reports - 4 month(s) ago
image image Crosslinking of microvilli in the intestinal brush border mediated by CDHR5 represents an important barrier against invasion of luminal bacteria. A combination of reduced crosslinking with increased mucus layer permeability may sensitize …
Source: www.embopress.orgCategories: General Medicine News, General HCPsTweet
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Mashup Score: 12IL‐27 produced during acute malaria infection regulates Plasmodium‐specific memory CD4+ T cells - 7 month(s) ago
IL-27 inhibits the generation of parasite-specific memory CD4+ T cells in a malaria infection model. Transient blockade of IL-27 elicits high levels of unique CD127+ and KLRG1+ memory CD4+ T cells, e…
Source: www.embopress.orgCategories: General Medicine News, Infectious DiseaseTweet
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Mashup Score: 9
This study employed a systems approach, involving network modeling and experimental validations, to uncover a new mechanism of action of ω3 polyunsaturated fatty acids (PUFA) in both NASH and liver c…
Source: www.embopress.orgCategories: General Medicine News, General NewsTweet
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Mashup Score: 2M‐CSF directs myeloid and NK cell differentiation to protect from CMV after hematopoietic cell transplantation - 7 month(s) ago
Herpesviridae like CMV are a major cause of morbidity and mortality in patients after HCT. Therapies reconstituting the host’s antiviral immunocompetence for prophylaxis and treatment are an unmet me…
Source: www.embopress.orgCategories: General Medicine News, Latest HeadlinesTweet
“The growth factor EPIREGULIN promotes basal progenitor proliferation in the developing neocortex” by Mareike Albert et al. EMBO Journal https://t.co/5YdPraNoOO