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Mashup Score: 20Year 4. January 13. Unimaginable. » Department of Medicine Blog - 4 month(s) ago
The events of the last week will leave an indelible imprint on all of us. We have all been impacted […]
Source: connect.uclahealth.orgCategories: General Medicine News, EndocrinologyTweet
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Mashup Score: 10Holiday Office Decoration Spectacular Competition 2024 - 5 month(s) ago
This is “Holiday Office Decoration Spectacular Competition 2024” by UCLA DOM on Vimeo, the home for high quality videos and the people who love them.
Source: vimeo.comCategories: General Medicine News, EndocrinologyTweet-
The Chief Residents @DOM_UCLA @dgsomucla, @uclahealth launched an office decoration challenge for the holidays. Winners were selected by popular vote. See the champion and my commentary on the runner up, that won my vote! https://t.co/X8nlWJGyom
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Mashup Score: 4IRS2 Signaling Protects Against Stress-Induced Arrhythmia by Maintaining Ca2+ Homeostasis | Circulation - 5 month(s) ago
BACKGROUND: The docking protein IRS2 (insulin receptor substrate protein-2) is an important mediator of insulin signaling and may also regulate other signaling pathways. Murine hearts with cardiomyocyte-restricted deletion of IRS2 (cIRS2-KO) are more susceptible to pressure overload–induced cardiac dysfunction, implying a critical protective role of IRS2 in cardiac adaptation to stress through mechanisms that are not fully understood. There is limited evidence regarding the function of IRS2 beyond metabolic homeostasis regulation, particularly in the context of cardiac disease. METHODS: A retrospective analysis of an electronic medical record database was conducted to identify patients with IRS2 variants and assess their risk of cardiac arrhythmias. Arrhythmia susceptibility was examined in cIRS2-KO mice. The underlying mechanisms were investigated using confocal calcium imaging of ex vivo whole hearts and isolated cardiomyocytes to assess calcium handling, Western blotting to analyze
Source: www.ahajournals.orgCategories: General Medicine News, EndocrinologyTweet-
https://t.co/3QP4Yv2OTx @nih_nhlbi,@Soc_HrtVasMetab, @HeartNews, @ADA_DiabetesPro
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Mashup Score: 1ASCI Perspectives - E. Dale Abel - short clip (October 2024) - 6 month(s) ago
Clip from an August 20, 2024, interview in the ASCI Perspectives series between Utibe Essien, MD, MPH, and E. Dale Abel, MBBS, DPhil, held at UCLA.
Source: vimeo.comCategories: General Medicine News, EndocrinologyTweet-
Sharing recent video done for @the_asci summarizing my journey and philosophy as a #PhysicianScientist. Posting this also on @intmedabel.bsky.social as many of my followers have moved over there. https://t.co/22N2mRNNgm https://t.co/JUbjg7xltp
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Mashup Score: 6Frontiers | ATF4-dependent and independent mitokine secretion from OPA1 deficient skeletal muscle in mice is sexually dimorphic - 8 month(s) ago
IntroductionReducing Optic Atrophy 1 (OPA1) expression in skeletal muscle in male mice induces Activation Transcription Factor 4 (ATF4) and the integrated st…
Source: www.frontiersin.orgCategories: General Medicine News, EndocrinologyTweet-
Just out in @FrontEndocrinol our paper with @StreeterLab showing complexity of mitokine secretion from skeletal muscle. Sex matters! #Mitochondria @RePereira https://t.co/8lKkAGYCfY https://t.co/MYWJqW0wp3
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Mashup Score: 0PCPE-1, a brown adipose tissue-derived cytokine, promotes obesity-induced liver fibrosis | The EMBO Journal - 8 month(s) ago
imageimageThe systemic control of tissue fibrosis by metabolic organs remains poorly understood. This study identifies procollagen C-endopeptidase enhancer-1 (PCPE-1) as an adipokine released from brown adipose tissue (BAT) upon dietary obesity. …
Source: www.embopress.orgCategories: General Medicine News, EndocrinologyTweet-
https://t.co/ARIPhP4xjE
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Mashup Score: 16
The systemic regulation of metabolic dysfunction-associated liver disease remains poorly understood. In this issue, Hsiao et al (2024) identify PCPE-1 as a brown-adipose tissue-derived mediator of …
Source: www.embopress.orgCategories: General Medicine News, EndocrinologyTweet-
Our editorial just out today in @embojournal on recent publication by @IppeiShimizuJPN providing evidence for a BATokine that promotes #Liver fibrosis in #obesity . @RePereira https://t.co/P7sDWje4tM
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Mashup Score: 144
Nature Neuroscience – Brain functions require a constant supply of glucose. However, the brain energy stores are unclear. Here, the authors show that oligodendroglial fatty acid metabolism can be…
Source: www.nature.comCategories: General Medicine News, EndocrinologyTweet-
Just out today in @NatureNeuro led by @EbrahimAsadoll3 & @KlausNave @mpi_nat. Pleased to have contributed. Oligodendrocytes break down & burn their fat when glucose is limited to fuel white matter. #Metabolism flexibility always key to survival. https://t.co/Y5SbumF9y7
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Mashup Score: 3IRS2 Signaling Protects Against Stress-Induced Arrhythmia by Maintaining Ca2+ Homeostasis | Circulation - 8 month(s) ago
BACKGROUND: The docking protein IRS2 (insulin receptor substrate protein-2) is an important mediator of insulin signaling and may also regulate other signaling pathways. Murine hearts with cardiomyocyte-restricted deletion of IRS2 (cIRS2-KO) are more susceptible to pressure overload–induced cardiac dysfunction, implying a critical protective role of IRS2 in cardiac adaptation to stress through mechanisms that are not fully understood. There is limited evidence regarding the function of IRS2 beyond metabolic homeostasis regulation, particularly in the context of cardiac disease. METHODS: A retrospective analysis of an electronic medical record database was conducted to identify patients with IRS2 variants and assess their risk of cardiac arrhythmias. Arrhythmia susceptibility was examined in cIRS2-KO mice. The underlying mechanisms were investigated using confocal calcium imaging of ex vivo whole hearts and isolated cardiomyocytes to assess calcium handling, Western blotting to analyze
Source: www.ahajournals.orgCategories: General Medicine News, EndocrinologyTweet-
https://t.co/3QP4Yv2OTx @nih_nhlbi,@Soc_HrtVasMetab, @HeartNews, @ADA_DiabetesPro
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Mashup Score: 32IRS2 Signaling Protects Against Stress-Induced Arrhythmia by Maintaining Ca2+ Homeostasis | Circulation - 8 month(s) ago
BACKGROUND: The docking protein IRS2 (insulin receptor substrate protein-2) is an important mediator of insulin signaling and may also regulate other signaling pathways. Murine hearts with cardiomyocyte-restricted deletion of IRS2 (cIRS2-KO) are more susceptible to pressure overload–induced cardiac dysfunction, implying a critical protective role of IRS2 in cardiac adaptation to stress through mechanisms that are not fully understood. There is limited evidence regarding the function of IRS2 beyond metabolic homeostasis regulation, particularly in the context of cardiac disease. METHODS: A retrospective analysis of an electronic medical record database was conducted to identify patients with IRS2 variants and assess their risk of cardiac arrhythmias. Arrhythmia susceptibility was examined in cIRS2-KO mice. The underlying mechanisms were investigated using confocal calcium imaging of ex vivo whole hearts and isolated cardiomyocytes to assess calcium handling, Western blotting to analyze
Source: www.ahajournals.orgCategories: General Medicine News, EndocrinologyTweet-
Just out in @CircAHA led by @qianshi_uiowa @LongShengSong1. Our new study showing novel mechanism by which insulin receptor substrate (IRS)2 signaling suppresses catecholamine induced ventricular arrythmia. @intmedatiowa, @AHAScience @theEndoSociety https://t.co/f3uqZegWeh
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Each week I write a message to my Department. This is what I wrote to them yesterday. https://t.co/83bCeAbwJ1