-
Mashup Score: 25The effect of intermittent fasting on microbiota as a therapeutic approach in obesity - 3 day(s) ago
Obesity, a public health challenge, arises from a complex interplay of factors such as dietary habits and genetic predisposition. Alterations in gut microbiota, characterized by an imbalance between Firmicutes and Bacteroidetes, further exacerbate metabolic dysregulation, promoting inflammation and metabolic disturbances. Intermittent fasting (IF) emerges as a promising dietary strategy showing efficacy in weight management and favoring fat utilization. Studies have used mice as animal models to demonstrate the impact of IF on gut microbiota composition, highlighting enhanced metabolism and reduced inflammation. In humans, preliminary evidence suggests that IF promotes a healthy microbiota profile, with increased richness and abundance of beneficial bacterial strains like Lactobacillus and Akkermansia. However, further clinical trials are necessary to validate these findings and elucidate the long-term effects of IF on microbiota and obesity. Future research should focus on specific ti
Source: www.frontiersin.orgCategories: General Medicine News, General HCPsTweet
-
Mashup Score: 38Frontiers | Overcoming the challenges encountered in CAR-T therapy: latest updates from the 2023 ASH annual conference - 3 day(s) ago
Chimeric antigen receptor (CAR) -T cell therapy has entered the breakthrough era, characterized by a blend of therapeutic opportunities and challenges. With …
Source: www.frontiersin.orgCategories: General Medicine News, Onc News and JournalsTweet
-
Mashup Score: 8Frontiers | Fast-forwarding collaborative surveillance - 4 day(s) ago
Join a complimentary virtual symposium on next steps for real-time, global genomic surveillance of pathogens. Department of Viroscience, Erasmus Medical Center, Rotterdam, Netherlands Multistakeholder commitment and investment is needed to establish worldwide integrated, systematic, collaborative disease surveillance capacity, including in low- and middle-income countries, based on One Health principles. True One Health surveillance will require the engagement of actors across all relevant domains
Source: www.frontiersin.orgCategories: General Medicine News, Infectious DiseaseTweet
-
Mashup Score: 24Frontiers | Real-time genomic surveillance for enhanced control of infectious diseases and antimicrobial resistance - 4 day(s) ago
This article advocates for mobilizing pathogen genomic surveillance to contain and mitigate health threats from infectious diseases and antimicrobial resista…
Source: www.frontiersin.orgCategories: General Medicine News, Infectious DiseaseTweet
-
Mashup Score: 0
Background: Pediatric narcolepsy is a chronic neurological disorder that impacts the health and overall well-being of children and adolescents with the disease. Meaningful and regular assessment of symptom frequency and severity is important for the long-term management of narcolepsy and for optimizing quality of life. However, there is currently no patient-reported outcomes (PROs) measure developed from both patient and expert input that is designed specifically to assess the impact of pediatric narcolepsy on daily life and overall disease burden. Methods: We conducted a qualitative mixed-methods study to develop a novel patient-reported outcomes measure for pediatric narcolepsy patients. We created and refined a conceptual framework through literature review, semi-structured interviews with narcolepsy experts, and focus groups of children and adolescents with narcolepsy and their parents. Guided by the domains and facets identified in our conceptual framework and further literature r
Source: www.frontiersin.orgCategories: General Medicine News, NeurologyTweet
-
Mashup Score: 7Current genetic diagnostics in inborn errors of immunity - 4 day(s) ago
New technologies in genetic diagnostics have revolutionized the understanding and management of rare diseases. This review highlights the significant advances and latest developments in genetic diagnostics in inborn errors of immunity (IEI), which encompass a diverse group of disorders characterized by defects in the immune system, leading to increased susceptibility to infections, autoimmunity, autoinflammatory diseases, allergies, and malignancies. Various diagnostic approaches, including targeted gene sequencing panels, whole exome sequencing, whole genome sequencing, RNA sequencing, or proteomics, have enabled the identification of causative genetic variants of rare diseases. These technologies not only facilitated the accurate diagnosis of IEI but also provided valuable insights into the underlying molecular mechanisms. Emerging technologies, currently mainly used in research, such as optical genome mapping, single cell sequencing or the application of artificial intelligence will
Source: www.frontiersin.orgCategories: General Medicine News, General HCPsTweet
-
Mashup Score: 7Brain-age estimation with a low-cost EEG-headset: effectiveness and implications for large-scale screening and brain optimization - 5 day(s) ago
Over time, pathological, genetic, environmental, and lifestyle factors can age the brain and diminish its functional capabilities. While these factors can lead to disorders that can be diagnosed and treated once they become symptomatic, often treatment is difficult or ineffective by the time significant overt symptoms appear. One approach to this problem is to develop a method for assessing general age-related brain health and function that can be implemented widely and inexpensively. To this end, we trained a machine-learning algorithm on resting-state EEG (RS-EEG) recordings obtained from healthy individuals as the core of a brain-age estimation technique that takes an individual’s RS-EEG recorded with the low-cost, user-friendly EMOTIV EPOC X headset and returns that person’s estimated brain age. We tested the current version of our machine-learning model against an independent test-set of healthy participants and obtained a correlation coefficient of 0.582 between the chronological
Source: www.frontiersin.orgCategories: General Medicine News, NeurologyTweet
-
Mashup Score: 5Construction and evaluation of a neurofeedback system using finger tapping and near-infrared spectroscopy - 5 day(s) ago
IntroductionNeurofeedback using near-infrared spectroscopy (NIRS) has been used in patients with stroke and other patients, but few studies have included older people or patients with cognitive impairment.MethodsWe constructed a NIRS-based neurofeedback system and used finger tapping to investigate whether neurofeedback can be implemented in older adults while finger tapping and whether brain activity improves in older adults and healthy participants. Our simple neurofeedback system was constructed using a portable wearable optical topography (WOT-HS) device. Brain activity was evaluated in 10 older and 31 healthy young individuals by measuring oxygenated hemoglobin concentration during finger tapping and neurofeedback implementation.ResultsDuring neurofeedback, the concentration of oxygenated hemoglobin increased in the prefrontal regions in both the young and older participants.DiscussionThe results of this study demonstrate the usefulness of neurofeedback using simple NIRS devices f
Source: www.frontiersin.orgCategories: General Medicine News, NeurologyTweet
-
Mashup Score: 3Frontiers | The efficacy and safety of short-term and low-dose IL-2 combined with tocilizumab to treat rheumatoid arthritis - 5 day(s) ago
BackgroundImmunotherapy targeting factors related to immune imbalance has been widely employed for RA treatment. This study aimed to evaluate the efficacy an…
Source: www.frontiersin.orgCategories: General Medicine News, General HCPsTweet
-
Mashup Score: 4Brain-age estimation with a low-cost EEG-headset: effectiveness and implications for large-scale screening and brain optimization - 6 day(s) ago
Over time, pathological, genetic, environmental, and lifestyle factors can age the brain and diminish its functional capabilities. While these factors can lead to disorders that can be diagnosed and treated once they become symptomatic, often treatment is difficult or ineffective by the time significant overt symptoms appear. One approach to this problem is to develop a method for assessing general age-related brain health and function that can be implemented widely and inexpensively. To this end, we trained a machine-learning algorithm on resting-state EEG (RS-EEG) recordings obtained from healthy individuals as the core of a brain-age estimation technique that takes an individual’s RS-EEG recorded with the low-cost, user-friendly EMOTIV EPOC X headset and returns that person’s estimated brain age. We tested the current version of our machine-learning model against an independent test-set of healthy participants and obtained a correlation coefficient of 0.582 between the chronological
Source: www.frontiersin.orgCategories: General Medicine News, NeurologyTweet
The effect of intermittent fasting on microbiota as a therapeutic approach in obesity https://t.co/Le8hkm2dYK