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Mashup Score: 0
Background: Pediatric narcolepsy is a chronic neurological disorder that impacts the health and overall well-being of children and adolescents with the disease. Meaningful and regular assessment of symptom frequency and severity is important for the long-term management of narcolepsy and for optimizing quality of life. However, there is currently no patient-reported outcomes (PROs) measure developed from both patient and expert input that is designed specifically to assess the impact of pediatric narcolepsy on daily life and overall disease burden. Methods: We conducted a qualitative mixed-methods study to develop a novel patient-reported outcomes measure for pediatric narcolepsy patients. We created and refined a conceptual framework through literature review, semi-structured interviews with narcolepsy experts, and focus groups of children and adolescents with narcolepsy and their parents. Guided by the domains and facets identified in our conceptual framework and further literature r
Source: www.frontiersin.orgCategories: General Medicine News, NeurologyTweet
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Mashup Score: 5Construction and evaluation of a neurofeedback system using finger tapping and near-infrared spectroscopy - 3 day(s) ago
IntroductionNeurofeedback using near-infrared spectroscopy (NIRS) has been used in patients with stroke and other patients, but few studies have included older people or patients with cognitive impairment.MethodsWe constructed a NIRS-based neurofeedback system and used finger tapping to investigate whether neurofeedback can be implemented in older adults while finger tapping and whether brain activity improves in older adults and healthy participants. Our simple neurofeedback system was constructed using a portable wearable optical topography (WOT-HS) device. Brain activity was evaluated in 10 older and 31 healthy young individuals by measuring oxygenated hemoglobin concentration during finger tapping and neurofeedback implementation.ResultsDuring neurofeedback, the concentration of oxygenated hemoglobin increased in the prefrontal regions in both the young and older participants.DiscussionThe results of this study demonstrate the usefulness of neurofeedback using simple NIRS devices f
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Mashup Score: 4
Physicians and doctors, professors, researchers and industry Physicians and doctors, professors, researchers and industry Residents, post-docs, optometrists, orthoptists, caregivers, partners of the Fondation Asile des aveugles The Low Vision Symposium provides the venue to link the latest scientific discoveries in low vision research to innovative interventional procedures for the management of low vision. Starting from the assessment of the behavioural consequences of low vision, the symposium will
Source: events.ophtalmique.chCategories: General Medicine News, NeurologyTweet
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Mashup Score: 4Brain-age estimation with a low-cost EEG-headset: effectiveness and implications for large-scale screening and brain optimization - 4 day(s) ago
Over time, pathological, genetic, environmental, and lifestyle factors can age the brain and diminish its functional capabilities. While these factors can lead to disorders that can be diagnosed and treated once they become symptomatic, often treatment is difficult or ineffective by the time significant overt symptoms appear. One approach to this problem is to develop a method for assessing general age-related brain health and function that can be implemented widely and inexpensively. To this end, we trained a machine-learning algorithm on resting-state EEG (RS-EEG) recordings obtained from healthy individuals as the core of a brain-age estimation technique that takes an individual’s RS-EEG recorded with the low-cost, user-friendly EMOTIV EPOC X headset and returns that person’s estimated brain age. We tested the current version of our machine-learning model against an independent test-set of healthy participants and obtained a correlation coefficient of 0.582 between the chronological
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Mashup Score: 4Virtual and Robotic Embodiment - 4 day(s) ago
Cognitive Neuroergonomics investigates mental processes at work or during everyday interactions with technical systems through neuroscientific methods. The goal is to improve interactions between the person and other elements of a system like a working environment through a user-centered design. Among these processes, the integration of artificial extensions into the users’ body scheme, i.e., embodiment, is especially useful for improving user experience and system control. In the literature, embodiment is related to phenomena like the feeling that non-bodily objects are integrated to become part of one’s own body, the adjustment of a person’s behavior to the characteristics of external items, and, more generally, to the activation of the individual motor system during the execution of cognitive tasks. In particular, the embodiment of avatars or robots constitutes a premise for successfully mediated interactions between the user and a comprehensive set of items such as environments, to
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Mashup Score: 12
BackgroundHypertension is a global issue that is projected to worsen with increasingly obese populations. The central nervous system including the parts of the cortex plays a key role in hemodynamic stability and homeostatic control of blood pressure (BP), making them critical components in understanding and investigating the neural control of BP. This study investigated the effects of anodal transcranial direct current stimulation (tDCS) associated with aerobic physical exercise on BP and heart rate variability in hypertensive patients.MethodsTwenty hypertensive patients were randomized into two groups: active tDCS associated with aerobic exercise or sham tDCS associated with aerobic exercise. BP and heart rate variability were analyzed before (baseline) and after twelve non-consecutive sessions. After each tDCS session (2 mA for 20 min), moderate-intensity aerobic exercise was carried out on a treadmill for 40 min.ResultsA total of 20 patients were enrolled (53.9 ± 10.6 years, 30.1 ±
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Mashup Score: 3
This study addresses concerns about reproducibility in scientific research, focusing on the use of electroencephalography (EEG) and machine learning to estimate mental workload. We established guidelines for reproducible machine learning research using EEG and used these to assess the current state of reproducibility in mental workload modeling. We first started by summarizing the current state of reproducibility efforts in machine learning and in EEG. Next, we performed a systematic literature review on Scopus, Web of Science, ACM Digital Library, and Pubmed databases to find studies about reproducibility in mental workload prediction using EEG. All of this previous work was used to formulate guidelines, which we structured along the widely recognized Cross-Industry Standard Process for Data Mining (CRISP-DM) framework. By using these guidelines, researchers can ensure transparency and comprehensiveness of their methodologies, therewith enhancing collaboration and knowledge-sharing wi
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Mashup Score: 1
Most U.S. Servicemembers (SMs) get less than the recommended amount of sleep per night, which has been shown to be directly influenced by local leadership. Previous research demonstrated that a brief sleep leadership training (SLT) protocol resulted in improved knowledge and attitudes regarding sleep among U.S. Army leaders, and improvements in the sleep health of their SMs. Human Performance Teams (HPT) offer one solution to propel the cultural change related to sleep, however, little is known about HPT members’ own sleep related knowledge, practices, attitudes, and beliefs. This mixed-methods study determined the effect of (SLT) on the sleep-related knowledge, practices, attitudes, beliefs, and perceived competency of HPT members, explored their experiences addressing SM sleep, and gauged their perceived value in receiving the training. Thirty-one individuals received 2 days of SLT. Baseline and 6-week post training follow-up measures were collected, and participants were invited to
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Mashup Score: 3Type I Interferon Activation in Neurological Diseases - 5 day(s) ago
Innate immunity, serving as the initial defense mechanism in an organism following a bacterial or viral infection, involves multiple pattern recognition receptors (PRRs) present in the plasma membranes, endosomes, and cytosol. These PRRs are responsible for recognizing the presence of foreign nucleic acids. The activation of the single-stranded RNA cytosolic sensor (Retinoic acid-inducible-I-like receptors or RIG-I) or the double-stranded RNA cytosolic sensor (MDA5) and the DNA cytosolic sensors (cGAS) leads to the transcription of Type I interferon and subsequently, the Interferon-stimulated genes (ISGs). These events play a crucial role in combating pathogen replication, contributing to local inflammation, and facilitating the recruitment of other cells from the adaptive immune system. Recent discoveries have shed light on the involvement of cell-intrinsic events in the upregulation of Type I interferon. Among the various mechanisms identified, mitochondrial dysfunction plays a signi
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Mashup Score: 0Objective and subjective sleep characteristics in hospitalized older adults and their associations to hospital outcomes - 5 day(s) ago
PurposeSleep in the hospital setting is understudied, with limited literature describing measurement of sleep quality. This study among older inpatients in an acute-care hospital describes sleep characteristics both objectively and subjectively, and explores the associations of sleep with hospital outcomes.Materials and methodsOlder patients (n = 112) at Sutter Tracy Community Hospital were enrolled from January 2016 to November 2017. Sleep prior to admission was measured subjectively [Pittsburgh Sleep Quality Index (PSQI)], while sleep during hospitalization was measured subjectively (sleep diaries) and objectively (actigraphy, averaged over all nights). Outcomes measured included change in cognition during the hospital stay (i.e., Montreal Cognitive Assessment), length of stay (LOS), discharge to a skilled nursing facility (SNF), and re-admittance to a hospital within 30 days of discharge.ResultsThe participants were on average 68.7 ± 6.5 years old, predominately white (77%) and 55%
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New Research: New Research: Development of the pediatric narcolepsy patient-reported outcomes scale (PN-PROs) https://t.co/RsGY74yvgi #SleepResearch