-
Mashup Score: 14Novel Approaches to Targeting the Vasculature and Metabolome to Prevent Brain Aging and Related Diseases - 2 day(s) ago
The human brain is highly metabolically active and expends about 20% of the body’s energy just for normal functioning. Neuronal activation locally leads to a transient increase in cerebral blood flow – a process called neurovascular coupling, thus ensuring that bioenergetic substrates are efficiently delivered to that region of the brain. Neurovascular coupling is brought about by the coordinated action of neurons, astrocytes and other glial cells, and endothelial cells and smooth muscle cells forming the blood vessels, collectively termed as the neurovascular unit. The neurovascular unit also functions to keep the blood brain barrier (BBB) intact. Normal neurovascular and neurometabolic coupling as well as BBB function are essential to maintain brain homeostasis and for proper cognitive function. As the brain ages, there is significant impairment of neurovascular coupling and the integrity of the BBB which leads to insufficient blood flow to the brain, reduced delivery of oxygen and b
Source: www.frontiersin.orgCategories: General Medicine News, NeurologyTweet
-
Mashup Score: 2Application of Chatbot Natural Language Processing Models to Psychotherapy and Behavioral Mood Health - 2 day(s) ago
The prevalence of mental health issues is rapidly increasing worldwide, whereas the gap between the need for treatment and the capacity to deliver it, is constantly increasing even in high-income countries. Though the COVID-19 pandemic had detrimental mental health consequences, including decreased cognition, decreased focus, performance problems, and changes in mood and behavior, it also offered new and advanced digital health applications within the fields of psychiatry and psychotherapy. These tools offer a promising new avenue for approaching mental health issues via a complementary to traditional care channel, that offers scalable interventions even in cases of lack of physical contact between the patient and the carer.The tremendous increase in Artificial Intelligence (AI) applications allows the early identification of mood disorders and digital psychological interventions. Natural Language Processing (NLP) techniques enable computers to understand unstructured text from social
Source: www.frontiersin.orgCategories: General Medicine News, NeurologyTweet-
🚀Submissions Open! @chfrantz E. Peristeri S. Ananiadou & K. Denecke are exploring the impact of #NLP in #digitalpsychiatry & #psychotherapy 👉https://t.co/lHVnS4tQXw Share insights on AI-driven solutions' effectiveness in #DigitalHealth #NLPResearch early identification of… https://t.co/9TDakB09ev https://t.co/If1EQywXde
-
-
Mashup Score: 3Neuroenergetics in Health and Disease - 3 day(s) ago
Bioenergetics play a crucial role in maintaining healthy neuronal functions. Understanding the intricate mechanisms underlying the bioenergetic requirements of neurons is vital for unraveling the energy dysfunctions associated with aging, neurodegenerative disorders, and traumatic brain injury.Through an interdisciplinary approach combining neuroscience, molecular biology, and biochemistry, this Research Topic aims to identify and characterize the specific metabolic pathways, cellular processes, and energy utilization patterns that support healthy neuronal function. By uncovering the unique bioenergetic demands of neurons, we can gain valuable insights into the vulnerabilities of these energy-intensive cells.In this way, the Research Topic seeks to investigate the consequences of energy dysfunction in aging, neurodegenerative conditions such as Alzheimer’s, Parkinson’s, and Huntington’s diseases, as well as traumatic brain injury. By scrutinizing the alterations in neuroenergetic profi
Source: www.frontiersin.orgCategories: General Medicine News, NeurologyTweet
-
Mashup Score: 03D inversion recovery ultrashort echo time MRI can detect demyelination in cuprizone-treated mice - 3 day(s) ago
PurposeTo test the ability of inversion-recovery ultrashort echo time (IR-UTE) MRI to directly detect demyelination in mice using a standard cuprizone mouse model.MethodsNon-aqueous myelin protons have ultrashort T2s and are “invisible” with conventional MRI sequences but can be detected with UTE sequences. The IR-UTE sequence uses an adiabatic inversion-recovery preparation to suppress the long T2 water signal so that the remaining signal is from the ultrashort T2 myelin component. In this study, eight 8-week-old C57BL/6 mice were fed cuprizone (n = 4) or control chow (n = 4) for 5 weeks and then imaged by 3D IR-UTE MRI. The differences in IR-UTE signal were compared in the major white matter tracts in the brain and correlated with the Luxol Fast Blue histochemical marker of myelin.ResultsIR-UTE signal decreased in cuprizone-treated mice in white matter known to be sensitive to demyelination in this model, such as the corpus callosum, but not in white matter known to be resistant to d
Source: www.frontiersin.orgCategories: General Medicine News, NeurologyTweet
-
Mashup Score: 3
The recent pandemic, which required social isolation for prolonged periods, has had a substantial impact on the social behavior and mental well-being of individuals that has extended far beyond the duration of societal lockdowns. While many of the effects of social isolation in institutional and other settings have been studied, the pandemic has attracted new attention to the consequences of social isolation and loneliness on both cognitive and emotional processing in a broader context. This spans aspects such as neonatal and juvenile brain development, emotional regulation in the adult brain, perception and prediction of sensory and social events, learning and memory, as well as clinical states such as anxiety, depression, and cognitive impairment in aging.In this Research Topic we welcome submissions that address the impact of loneliness and social isolation in humans and animals on cognitive and emotional processing encompassing, but not exclusively limited to, the following themes:
Source: www.frontiersin.orgCategories: General Medicine News, NeurologyTweet
-
Mashup Score: 8Investigation of causal effects of blood metabolites on insomnia and circadian rhythm sleep wake disorders - 9 day(s) ago
BackgroundInsomnia (IS) and circadian rhythm sleep-wake disorders (CRSWD) are complex disorders with limited and unsatisfactory treatment options that can even cause some side effects. By analyzing blood metabolites to reveal underlying biological processes, studies of sleep and the complex interactions between its influencing factors can be elucidated. Therefore, we hope to bring new hope for the treatment of these diseases through blood metabolites.AimsInvestigating the causal link between blood metabolites and IS and CRSWD.MethodsA genome-wide association study (GWAS) for 486 metabolites was used as the exposure, whereas two different GWAS datasets for sleep disorders were the outcome, and all datasets were obtained from publicly available databases. We employed the standard inverse variance weighting (IVW) method for causal analysis, supported by the MR-Egger method, weighted median (WM) method, and MR-PRESSO method for sensitivity analysis to mitigate the impact of pleiotropy. Gen
Source: www.frontiersin.orgCategories: General Medicine News, NeurologyTweet
-
Mashup Score: 02nd Workshop on "Mechanisms, Therapies, and Biomarkers in Neurodevelopmental Disorders” - 9 day(s) ago
Location: Sala Azzurra, Scuola Normale Superiore, Pisa. Date: Saturday May 18th 2024 Registration form Registration is free of charge and it is compulsory for participation. When registering please also indicate whether or not you intend to present a poster.
Source: docs.google.comCategories: General Medicine News, NeurologyTweet
-
Mashup Score: 0Real-World Challenges for Long-Term Wearable Technologies - 9 day(s) ago
The use of wearable technologies and mobile digital health in neurosciences has shown great potential in advancing our understanding of brain function and improving the diagnosis and management of neurological conditions. However, there are significant challenges that must be addressed before these technologies can be widely adopted in clinical practice and in the real world. These challenges include data privacy and security, user acceptance and adoption, accuracy and reliability, and robustness against real-world artifacts and variability. Moreover, device miniaturization has improved the portability of wearable devices; however, it comes with reduced battery size, hence, there is an urge for wearable solutions that are energy efficient and consume low power to ensure a long battery lifetime. On the other hand, machine learning and deep learning algorithms have proven to be promising for accurate performance, but they are often too resource-demanding for small wearable solutions. The
Source: www.frontiersin.orgCategories: General Medicine News, NeurologyTweet
-
Mashup Score: 0Medical Neurohumanities: Sharing Insights from Medicine, Neuroscience and Music in Pediatric Care - 9 day(s) ago
Neurohumanities have long been debated but seldom applied in medicine, with the important relationship between music sciences, music therapy, and pediatric care remaining underexplored. As our understanding of the – young – brain continues to expand, it is crucial to create a shared lexicon that connects music, neuroscience, technological innovations, pediatrics, and healthcare. By fostering interdisciplinary collaboration, we can deepen our comprehension of the working mechanisms of music therapies and medical interventions for pediatric patients. Sharing insights, approaches, methods, and interventions promotes interdisciplinary understanding, enabling the development of more effective, patient-centered healthcare strategies that consider ethical aspects, shared therapeutic goals, and medical responsibilities.The goal is to synergistically integrate knowledge from pediatrics, music therapy, and music medicine to develop purposeful, socially and clinically validated treatments. By mer
Source: www.frontiersin.orgCategories: General Medicine News, NeurologyTweet
-
Mashup Score: 0Sleepy and popular? The association between popularity, sleep duration, and insomnia in adolescents - 11 day(s) ago
IntroductionDuring adolescence, peers gain a central role and with the availability of technology, socializing can occur around the clock. Very few studies have focused on the role of peers in adolescents’ sleep using social network analyses. These analyses describe peer relationships and social positions in a defined context (e.g., school) based on friendship nominations. Adolescents who receive many nominations can be defined as “popular,” which has been found to have its costs (i.e., shorter sleep duration) but also benefits (i.e., fewer insomnia symptoms). The aim of this study was to partially replicate and expand previous findings in a large Swedish sample of adolescents.MethodThe sample included 1,394 adolescents (46% girls, Mage = 15.3, SD = 0.53, range 14–18) from 16 public schools in middle Sweden. Adolescents reported on their weekly sleep duration, insomnia symptoms, anxiety, depression, alcohol use, demographics, and nominated up to three friends in school. We used R to ca
Source: www.frontiersin.orgCategories: General Medicine News, NeurologyTweet
A research topic, via Frontiers in Cellular Neuroscience will explore groundbreaking research on Novel Approaches Targeting the Vasculature and Metabolome to Prevent Brain Aging and Related Diseases. Closing date 14 May 2024. Make your contribution ➡️ https://t.co/72A5DgCXn7 https://t.co/QmTLggq0mK