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Mashup Score: 1Constructive correction - 7 month(s) ago
A fundamental tenet of the scientific process is that science is self-correcting. Efficient correction of the scientific literature requires a more nuanced set of policies and tools that lower the ba…
Source: www.embopress.orgCategories: Cardiologists, Latest HeadlinesTweet
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Mashup Score: 2mAb therapy controls CNS‐resident lyssavirus infection via a CD4 T cell‐dependent mechanism - 8 month(s) ago
Rabies is a fatal viral disease of humans, with uniform mortality once central nervous system (CNS) invasion occurs and symptoms appear. This study demonstrates that a single-dose monoclonal (mAb) th…
Source: www.embopress.orgCategories: Infectious Disease, Latest HeadlinesTweet-
This study out of @USUhealthsci shows that a single dose of F11, an anti-lyssavirus human monoclonal #antibody, limited viral load in the 🧠 brain and reversed disease signs following #infection with a lethal dose of #lyssavirus! @EmboMolMed | https://t.co/xdo3th54zX https://t.co/f6rT6ojs3J
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Mashup Score: 9Single‐cell profiling and zebrafish avatars reveal LGALS1 as immunomodulating target in glioblastoma - 8 month(s) ago
scRNA-seq and live-imaging in zebrafish avatars were used to study the complex and dynamic interplay between GBM tumor cells and GAMs, and provide fresh perspectives and opportunities for discovering…
Source: www.embopress.orgCategories: General Medicine News, Latest HeadlinesTweet-
Zebrafish avatars can help tailor #glioblastoma therapies https://t.co/q77NTWvHYm https://t.co/zwg7227iTu
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Mashup Score: 1The fountain of youth of mitochondrial research - 8 month(s) ago
A new wave of studies is untangling the connection between primary genetic mitochondrial diseases and the role of mitochondria in aging: what are the implications for longevity?
Source: www.embopress.orgCategories: Healthcare Professionals, Latest HeadlinesTweet-
The fountain of youth of mitochondrial research: Research is targeting mitochondrial dysfunction to tackle aging and much more, but hype is an increasing concern https://t.co/vdDwRgiSKx via @acrinaldi67 https://t.co/7GmFmfBtGf
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Mashup Score: 5Systemic gene therapy rescues retinal dysfunction and hearing loss in a model of Norrie disease - 9 month(s) ago
Norrie disease is a genetic condition causing blindness and progressive deafness. Successful AAV-mediated gene augmentation therapy in a mouse model showed that the Norrie phenotype is responsive to …
Source: www.embopress.orgCategories: General Medicine News, Latest HeadlinesTweet-
Novel #genetherapy significantly reduces #hearingloss linked to rare disease in mouse model @uclnews https://t.co/q3IksoGTme https://t.co/IH6aX4D8bw
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Mashup Score: 14Patronin/CAMSAP promotes reactivation and regeneration of Drosophila quiescent neural stem cells - 10 month(s) ago
Drosophila Patronin promotes reactivation of quiescent neural stem cells (qNSCs) by regulating acentrosomal microtubule growth. It functions upstream of the Golgi-resident small GTPase Arf1, and it i…
Source: www.embopress.orgCategories: General Medicine News, Latest HeadlinesTweet-
Tapping into #regeneration: New paths to repairing brain injury discovered in #fruitflies @dukenus @emboreports https://t.co/SibJrgEWHL https://t.co/EdKcke7HhK
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Mashup Score: 0TLR2 and TLR7 mediate distinct immunopathological and antiviral plasmacytoid dendritic cell responses to SARS‐CoV‐2 infection | The EMBO Journal - 2 year(s) ago
Understanding the molecular pathways driving the acute antiviral and inflammatory response to SARS-CoV-2 infection is critical for developing treatments for severe COVID-19. Here, we find decreasing …
Source: www.embopress.orgCategories: Infectious Disease, Latest HeadlinesTweet-
Dr. Martin Jakobsen at @AarhusUni and co-researchers show that SARS-CoV-2 engages the receptor neuropilin-1 plasmacytoid dendritic cells to selectively mitigate the #antiviral interferon response, but not the IL-6 response. https://t.co/noE6aAWZhP https://t.co/N73tqw74M5
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Mashup Score: 2
A novel drug-screening platform compatible with patient-derived samples identifies effective therapies to prevent brain metastasis.
Source: www.embopress.orgCategories: Hem/Oncs, Latest HeadlinesTweet-
A clinically compatible drug‐screening platform based on organotypic cultures identifies vulnerabilities to prevent and treat brain metastasis | EMBO Molecular Medicine https://t.co/DbyTZFp0KD
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Mashup Score: 14Identification of treatment‐induced vulnerabilities in pancreatic cancer patients using functional model systems | EMBO Molecular Medicine - 2 year(s) ago
Therapy resistance remains a major challenge in pancreatic cancer. This study used patient-derived organoids (PDOs) and cell lines (PDCL) to investigate response to standard of care chemotherapy admi…
Source: www.embopress.orgCategories: Hem/Oncs, Latest HeadlinesTweet-
By @MaxReichertMD @SaurLab et al @EmboMolMed Identification of treatment-induced vulnerabilities in #PancreaticCancer patients using functional model systems https://t.co/93cuWfR1sd Treatment changes cancer cells (not surprisingly) - can this plasticity be exploited in patients? https://t.co/29NYlL0Y4O
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Mashup Score: 1The unfolded protein response links tumor aneuploidy to local immune dysregulation | EMBO reports - 3 year(s) ago
Aneuploidy, the unfolded protein response (UPR) and dysregulated local immunity are a common feature of human solid tumors, however, the relationship between these three variables has not been explor…
Source: www.embopress.orgCategories: Latest Headlines, Oncologists2Tweet-
The unfolded protein response links tumor aneuploidy to local immune dysregulation | EMBO reports https://t.co/E4ZL5dHZra
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Constructive correction: a fundamental tenet of the scientific process is that science is self-correcting https://t.co/5iNlV2gaor