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Mashup Score: 160A pan-cancer analysis of the microbiome in metastatic cancer - 12 hour(s) ago
Characterization of microbiome genomes at the species level in over 4,000 metastatic tumor biopsies identifies the distribution and diversity features of tumor-resident bacterial DNA at a pan-cancer scale, highlighting the associations between microbial community dynamics and tumor immunity and immunotherapy efficacy.
Source: www.cell.comCategories: General Medicine News, General Journals & SocietTweet
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Mashup Score: 57A genome-wide spectrum of tandem repeat expansions in 338,963 humans - 16 hour(s) ago
The Tandem Repeat Genome Aggregation Database (TR-gnomAD) is a biobank-scale reference of 0.86 million TRs derived from 338,963 whole-genome sequencing (WGS) samples of diverse ancestries.
Source: www.cell.comCategories: General Medicine News, General HCPsTweet
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Mashup Score: 91Exploring new perspectives in immunology - 16 hour(s) ago
Despite deep knowledge of how the immune system works, many questions remain difficult to answer within the current core framework of innate and adaptive immunity. This perspective highlights open questions where a change in the conceptual approach could be transformative for addressing persistent challenges to human health.
Source: www.cell.comCategories: General Medicine News, Expert PicksTweet
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Mashup Score: 35CD80 on skin stem cells promotes local expansion of regulatory T cells upon injury to orchestrate repair within an inflammatory environment - 16 hour(s) ago
In skin injury, the inflammatory environment can impact repair mediated by skin stem cells. Luan, Truong, Vuchkovska, et al. show that hair follicle stem cells migrate into the wound, activate immune-modulatory molecules, and expand extrathymic regulatory T cells to facilitate the resolution of neutrophil responses and the initiation of wound repair.
Source: www.cell.comCategories: General Medicine News, Allergy-ImmunologyTweet
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Mashup Score: 62
Diepstraten et al. demonstrate that p53 enforces apoptosis induced by BH3-mimetic drugs. To boost BH3-mimetic-induced apoptosis in TP53-mutant blood cancers, STING agonists were employed to induce pro-apoptotic BH3-only protein expression in a p53-independent manner. Therefore, BH3-mimetics alongside STING agonists represents a promising new combination therapy for aggressive TP53-mutant blood cancers.
Source: www.cell.comCategories: General Medicine News, Onc News and JournalsTweet
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Mashup Score: 0Loss of LPAR6 and CAB39L dysregulates the basal-to-luminal urothelial differentiation program, contributing to bladder carcinogenesis - 16 hour(s) ago
Lee et al. report that FR genes mapping near RB1 are associated with the development of field effects initiating bladder carcinogenesis. Two of these genes are distinctively downregulated in luminal and basal cancers. Their loss contributes to carcinogenesis by dysregulating urothelial differentiation mediated by cholesterol and the unfolded protein reaction.
Source: www.cell.comCategories: General Medicine News, General HCPsTweet
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Mashup Score: 4
In this article Minchiotti, Patriarca, and colleagues show that gastruloid formation provides an additional test of the developmental fidelity of stem cells. This study reveals that LIF exerts a dominant effect over exogenous FGF/ACTIVIN to provide gastruloid development competence, and suggests that a certain degree of phenotypic heterogeneity in the stem cell population is essential to generate functional cell aggregates.
Source: www.cell.comCategories: General Medicine News, General HCPsTweet
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Mashup Score: 13Aims and scope: Trends in Biotechnology - 17 hour(s) ago
Trends in Biotechnology is a monthly journal that publishes innovative applications of biology as useful technologies. Our articles should describe biobased solutions to important problems and should emphasize how to engineer or adapt living systems for societal benefit. Specific application areas include human health and well-being, renewable energy, food and agriculture, natural resources, and production of bulk and fine chemicals. A Trends in Biotechnology article should not merely summarize lab-scale
Source: www.cell.comCategories: General Medicine News, General HCPsTweet
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Mashup Score: 4Enhancing food production in hot climates through radiative cooling mulch: A nexus approach - 18 hour(s) ago
To eliminate damage to crops from high soil temperature and reduce soil evaporation, a radiative cooling mulch was applied to passively cool down the soil. By virtue of its high reflectivity in the solar spectra and high emissivity in the atmospheric window, the mulch can decrease the soil temperature at 2 cm depth by 12.5°C. In the field test during summer, the yield of Chinese Cabbage was improved by 127.4% after using this mulch. The applicability of this mulch on a global scale was discussed.
Source: www.cell.comCategories: General Medicine News, General HCPsTweet
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Mashup Score: 48Telomeres: history, health, and hallmarks of aging - 18 hour(s) ago
Telomere attrition and dysfunction causes and consequences of cellular and molecular aging and age-related disease. Mounting data revel how telomeres are entwined with other aging hallmarks and may be therapeutic targets for aging and age-related disease.
Source: www.cell.comCategories: General Medicine News, Hem/OncsTweet
Now online! A pan-cancer analysis of the microbiome in metastatic cancer https://t.co/drkg0KM6P3